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ONTOLOGY REPORT - ANNOTATIONS


Term:somatic diversification of immune receptors
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Accession:GO:0002200 term browser browse the term
Definition:The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.
Comment:Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification.



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immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POLB DNA polymerase beta involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:24388753) Ensembl
MGI
PMID:24388753 GO_REF:0000107 NCBI chr16:23,306,359...23,335,352
Ensembl chr16:23,306,367...23,335,322
JBrowse link
G YY1 YY1 transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:68,539,511...68,572,796
Ensembl chr 8:68,539,353...68,568,058
JBrowse link
immunoglobulin V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYREN cell cycle regulator of NHEJ involved_in ISO (MGI:6202149|PMID:30017584), (MGI:6716972|PMID:31795137) UniProt PMID:30017584 PMID:31795137 MGI:6202149 MGI:6716972 NCBI chr16:12,994,508...13,003,632
Ensembl chr16:12,994,479...12,998,435
JBrowse link
G FOXP1 forkhead box P1 acts_upstream_of_or_within ISO (PMID:16819554) MGI PMID:16819554 NCBI chr20:20,438,631...21,020,516
Ensembl chr20:20,788,433...21,016,397
JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9823897) Ensembl
MGI
TreeGrafter
PMID:9823897 GO_REF:0000107 GO_REF:0000118 NCBI chr22:56,980,333...56,987,636
Ensembl chr22:56,980,622...56,983,357
JBrowse link
G NHEJ1 non-homologous end joining factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:25,637,214...25,719,241
Ensembl chr37:25,637,601...25,715,372
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
(PMID:9768755) GO_Central
MGI
TreeGrafter
PMID:9768755 GO_REF:0000033 GO_REF:0000118 NCBI chr29:24,904...243,926
Ensembl chr29:35,007...243,895
JBrowse link
G TCF3 transcription factor 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:16428437) MGI
TreeGrafter
Ensembl
PMID:16428437 GO_REF:0000107 GO_REF:0000118 NCBI chr20:57,255,091...57,284,223
Ensembl chr20:57,254,384...57,283,981
JBrowse link
G XRCC4 X-ray repair cross complementing 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9875844) TreeGrafter
MGI
PMID:9875844 GO_REF:0000118 NCBI chr 3:24,316,598...24,547,463
Ensembl chr 3:24,269,974...24,533,465
JBrowse link
isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17713479) Ensembl
MGI
PMID:17713479 GO_REF:0000107 NCBI chr27:37,064,107...37,073,791
Ensembl chr27:37,064,080...37,073,789
JBrowse link
G ATAD5 ATPase family AAA domain containing 5 involved_in
acts_upstream_of
IEA
ISO
(PMID:25404367) Ensembl
MGI
PMID:25404367 GO_REF:0000107 NCBI chr 9:40,869,778...40,917,976
Ensembl chr 9:40,870,924...40,915,629
JBrowse link
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:48,537,036...48,561,154 JBrowse link
G CD40LG CD40 ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:107,001,421...107,023,007
Ensembl chr  X:107,010,890...107,023,006
JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15280420) Ensembl
MGI
PMID:15280420 GO_REF:0000107 NCBI chr 1:110,130,353...110,146,660
Ensembl chr 1:110,130,481...110,146,602
JBrowse link
G EXO1 exonuclease 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14716311) Ensembl
MGI
PMID:14716311 GO_REF:0000107 NCBI chr 7:33,237,124...33,268,835
Ensembl chr 7:33,237,593...33,268,254
JBrowse link
G EXOSC3 exosome component 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:54,072,993...54,079,024
Ensembl chr11:54,073,313...54,078,598
JBrowse link
G EXOSC6 exosome component 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:76,286,286...76,287,667
Ensembl chr 5:76,286,789...76,287,976
JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17713479) Ensembl
MGI
PMID:17713479 GO_REF:0000107 NCBI chr22:56,980,333...56,987,636
Ensembl chr22:56,980,622...56,983,357
JBrowse link
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12743174) Ensembl
MGI
PMID:12743174 GO_REF:0000107 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10430621)
(PMID:12743174)
Ensembl
MGI
PMID:10430621 PMID:12743174 GO_REF:0000107 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210
JBrowse link
G MSH6 mutS homolog 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16618598)
(PMID:17015724)
Ensembl
MGI
PMID:16618598 PMID:17015724 GO_REF:0000107 NCBI chr10:49,825,330...49,838,036
Ensembl chr10:49,803,898...49,838,028
JBrowse link
G NBN nibrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:35,416,093...35,477,569
Ensembl chr29:35,416,093...35,477,563
JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:8,147,160...8,154,401
Ensembl chr33:8,073,840...8,154,561
JBrowse link
G RNF168 ring finger protein 168 involved_in ISO (MGI:4420833|PMID:20080757) UniProt PMID:20080757 MGI:4420833 NCBI chr33:29,542,209...29,575,127
Ensembl chr33:29,539,182...29,628,248
JBrowse link
G RNF8 ring finger protein 8 involved_in ISO (MGI:4420833|PMID:20080757) UniProt PMID:20080757 MGI:4420833 NCBI chr12:6,380,365...6,415,407
Ensembl chr12:6,292,459...6,415,382
JBrowse link
G SANBR SANT and BTB domain regulator of CSR involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:61,143,971...61,195,058
Ensembl chr10:61,123,655...61,193,241
JBrowse link
G SWAP70 switching B cell complex subunit SWAP70 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9642267) Ensembl
MGI
PMID:9642267 GO_REF:0000107 NCBI chr21:32,910,547...32,985,617
Ensembl chr21:32,910,563...32,984,580
JBrowse link
G UNG uracil DNA glycosylase acts_upstream_of_or_within ISO (PMID:17015724) MGI PMID:17015724 NCBI chr26:17,900,354...17,911,126
Ensembl chr26:17,901,357...17,911,288
JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:17713479) MGI PMID:17713479 NCBI chr 3:24,316,598...24,547,463
Ensembl chr 3:24,269,974...24,533,465
JBrowse link
isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR6 C-C motif chemokine receptor 6 involved_in ISO (MGI:5787846|PMID:27174992) UniProt PMID:27174992 MGI:5787846 NCBI chr 1:54,932,798...54,960,646
Ensembl chr 1:54,932,690...54,959,740
JBrowse link
isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of
IEA
ISO
(PMID:10490661) Ensembl
MGI
PMID:10490661 GO_REF:0000107 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704
JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of
IEA
ISO
(PMID:16275384) Ensembl
MGI
PMID:16275384 GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758
JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534
JBrowse link
G RTP2 receptor transporter protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:20,087,395...20,091,248
Ensembl chr34:20,087,226...20,115,428
JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of
IEA
ISO
(PMID:10490661) Ensembl
MGI
PMID:10490661 GO_REF:0000107 NCBI chr10:1,232,515...1,247,011
Ensembl chr10:1,233,691...1,247,075
JBrowse link
isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPD1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:16148103) BHF-UCL PMID:16148103 NCBI chr37:7,010,421...7,025,912 JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534
JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARP3 poly(ADP-ribose) polymerase family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:37,767,336...37,774,269
Ensembl chr20:37,767,505...37,773,770
JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10490661) Ensembl
MGI
PMID:10490661 GO_REF:0000107 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704
JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16275384) Ensembl
MGI
PMID:16275384 GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758
JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17137798) Ensembl
MGI
PMID:17137798 GO_REF:0000107 NCBI chr 2:36,978,148...37,065,247
Ensembl chr 2:36,961,024...37,064,303
JBrowse link
G RTP2 receptor transporter protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:20,087,395...20,091,248
Ensembl chr34:20,087,226...20,115,428
JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:3763508|PMID:12496423) BHF-UCL PMID:12496423 MGI:3763508 NCBI chr 7:25,883,297...25,909,608
Ensembl chr 7:25,883,251...25,906,892
JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EXOSC3 exosome component 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21255825) Ensembl
MGI
PMID:21255825 GO_REF:0000107 NCBI chr11:54,072,993...54,079,024
Ensembl chr11:54,073,313...54,078,598
JBrowse link
G EXOSC6 exosome component 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21255825) Ensembl
MGI
PMID:21255825 GO_REF:0000107 NCBI chr 5:76,286,286...76,287,667
Ensembl chr 5:76,286,789...76,287,976
JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:2,808,687...2,831,123
Ensembl chr20:2,808,689...2,830,462
JBrowse link
G KMT5B lysine methyltransferase 5B involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:49,655,783...49,691,899
Ensembl chr18:49,637,610...49,827,034
JBrowse link
G KMT5C lysine methyltransferase 5C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:102,334,687...102,342,090
Ensembl chr 1:102,333,543...102,342,118
JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:84,539,724...84,549,402
Ensembl chr 2:84,545,226...84,549,356
JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:18,066,289...18,116,007
Ensembl chr16:18,066,246...18,112,506
JBrowse link
G RIF1 replication timing regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:52,661,278...52,711,969
Ensembl chr19:52,661,155...52,709,279
JBrowse link
G SHLD1 shieldin complex subunit 1 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr24:15,957,863...16,037,336
Ensembl chr24:15,957,852...16,038,008
JBrowse link
G SHLD2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chr 4:34,665,111...34,740,645
Ensembl chr 4:34,688,245...34,763,705
JBrowse link
G SHLD3 shieldin complex subunit 3 involved_in IEA TreeGrafter GO_REF:0000118
G TFRC transferrin receptor involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr33:29,206,024...29,237,221
Ensembl chr33:29,208,609...29,238,242
JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:10,263,650...10,362,646
Ensembl chr30:10,263,650...10,336,134
JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B9D2 B9 domain containing 2 acts_upstream_of_or_within ISO (PMID:14988498) MGI PMID:14988498 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
JBrowse link
G MLH1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116
JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210
JBrowse link
G NSD2 nuclear receptor binding SET domain protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23241889) Ensembl
MGI
PMID:23241889 GO_REF:0000107 NCBI chr 3:62,164,888...62,228,006
Ensembl chr 3:62,167,939...62,228,035
JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:11,411,062...11,438,767
Ensembl chr 6:11,349,453...11,438,940
JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in ISS
IEA
AgBase
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 1:112,629,476...112,643,885
Ensembl chr 1:112,621,633...112,643,885
JBrowse link
G TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:32,473,543...32,481,596
Ensembl chr 5:32,473,083...32,481,121
JBrowse link
G TNFSF13 TNF superfamily member 13 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:14988498) MGI
TreeGrafter
Ensembl
PMID:14988498 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:32,482,723...32,484,790
Ensembl chr 5:32,482,723...32,484,789
JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCF1 cardiotrophin like cytokine factor 1 involved_in ISO (MGI:3777853|PMID:12023368) BHF-UCL PMID:12023368 MGI:3777853 NCBI chr18:50,084,120...50,093,825
Ensembl chr18:50,083,915...50,102,651
JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within
ISS
ISO
(PMID:14988498) UniProt
MGI
PMID:14988498 GO_REF:0000024 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534
JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10490661) Ensembl
MGI
PMID:10490661 GO_REF:0000107 NCBI chr10:1,232,515...1,247,011
Ensembl chr10:1,233,691...1,247,075
JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAD5 ATPase family AAA domain containing 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:25404367) Ensembl
MGI
PMID:25404367 GO_REF:0000107 NCBI chr 9:40,869,778...40,917,976
Ensembl chr 9:40,870,924...40,915,629
JBrowse link
G CD28 CD28 molecule involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:7688139) Ensembl
MGI
PMID:7688139 GO_REF:0000107 NCBI chr37:12,503,849...12,536,362
Ensembl chr37:12,503,811...12,532,854
JBrowse link
G CD40 CD40 molecule involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12882831) TreeGrafter
MGI
PMID:12882831 GO_REF:0000118 NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301
JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698
JBrowse link
G IL2 interleukin 2 acts_upstream_of_or_within ISO (PMID:1830926) MGI PMID:1830926 NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394
JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within
ISS
ISO
(PMID:12882831), (PMID:14988498) UniProt
MGI
PMID:12882831 PMID:14988498 GO_REF:0000024 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534
JBrowse link
G MLH1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116
JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210
JBrowse link
G PAGR1 PAXIP1 associated glutamate rich protein 1 involved_in ISO (MGI:5752090|PMID:26744420) UniProt PMID:26744420 MGI:5752090 NCBI chr 6:17,876,740...17,879,546 JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:18,066,289...18,116,007
Ensembl chr16:18,066,246...18,112,506
JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:11,411,062...11,438,767
Ensembl chr 6:11,349,453...11,438,940
JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9015183) Ensembl
MGI
PMID:9015183 GO_REF:0000107 NCBI chr 7:4,155,876...4,282,151
Ensembl chr 7:4,137,728...4,282,124
JBrowse link
G TBX21 T-box transcription factor 21 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12882831) Ensembl
MGI
PMID:12882831 GO_REF:0000107 NCBI chr 9:24,077,752...24,086,560
Ensembl chr 9:24,077,761...24,086,261
JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLF aprataxin and PNKP like factor acts_upstream_of_or_within ISO (PMID:21211721) MGI PMID:21211721 NCBI chr10:67,454,500...67,522,659
Ensembl chr10:67,454,356...67,521,761
JBrowse link
G MIR181B-2 microRNA mir-181b-2 acts_upstream_of_or_within ISO (PMID:18762567) MGI PMID:18762567 NCBI chr 9:58,301,314...58,301,373
Ensembl chr 9:58,301,300...58,301,388
JBrowse link
G MIR181D microRNA mir-181d acts_upstream_of_or_within ISO (PMID:18762567) MGI PMID:18762567 NCBI chr20:48,593,158...48,593,221 JBrowse link
G SUPT6H SPT6 homolog, histone chaperone and transcription elongation factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:42,859,154...42,896,044
Ensembl chr 9:42,859,361...42,904,487
JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16275384) Ensembl
MGI
PMID:16275384 GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758
JBrowse link
G IL27RA interleukin 27 receptor subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11057672) Ensembl
MGI
PMID:11057672 GO_REF:0000107 NCBI chr20:48,456,766...48,475,414
Ensembl chr20:48,457,134...48,472,450
JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17137798) Ensembl
MGI
PMID:17137798 GO_REF:0000107 NCBI chr 2:36,978,148...37,065,247
Ensembl chr 2:36,961,024...37,064,303
JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:2,803,798...2,832,057
Ensembl chr26:2,802,724...2,831,530
JBrowse link
somatic diversification of immune receptors via somatic mutation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAR adenosine deaminase RNA specific involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23209284) Ensembl
MGI
PMID:23209284 GO_REF:0000107 NCBI chr 7:42,762,021...42,785,192
Ensembl chr 7:42,748,136...42,782,999
JBrowse link
somatic diversification of immunoglobulins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:37,064,107...37,073,791
Ensembl chr27:37,064,080...37,073,789
JBrowse link
G CTNNBL1 catenin beta like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:26,253,884...26,415,166
Ensembl chr24:26,253,962...26,415,163
JBrowse link
G POLB DNA polymerase beta involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:24388753) Ensembl
MGI
PMID:24388753 GO_REF:0000107 NCBI chr16:23,306,359...23,335,352
Ensembl chr16:23,306,367...23,335,322
JBrowse link
somatic hypermutation of immunoglobulin genes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr27:37,064,107...37,073,791
Ensembl chr27:37,064,080...37,073,789
JBrowse link
G EXO1 exonuclease 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14716311) Ensembl
MGI
PMID:14716311 GO_REF:0000107 NCBI chr 7:33,237,124...33,268,835
Ensembl chr 7:33,237,593...33,268,254
JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:2,808,687...2,831,123
Ensembl chr20:2,808,689...2,830,462
JBrowse link
G MCM3AP minichromosome maintenance complex component 3 associated protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr31:39,507,714...39,559,855
Ensembl chr31:39,507,729...39,561,674
JBrowse link
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10092760), (PMID:10429667) Ensembl
MGI
TreeGrafter
PMID:10092760 PMID:10429667 GO_REF:0000107 GO_REF:0000118 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
NOT|acts_upstream_of_or_within
IEA
ISO
(PMID:14568978)
(PMID:9607915)
(PMID:15494304)
(PMID:9607916)
(PMID:9697842), (PMID:9697843)
Ensembl
MGI
PMID:9607915 PMID:9607916 PMID:9697842 PMID:9697843 PMID:14568978 More... GO_REF:0000107 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210
JBrowse link
G MSH3 mutS homolog 3 NOT|acts_upstream_of_or_within ISO (PMID:10662804) MGI PMID:10662804 NCBI chr 3:26,335,788...26,520,633
Ensembl chr 3:26,336,403...26,518,521
JBrowse link
G MSH6 mutS homolog 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16618598)
(PMID:10662804), (PMID:15238604), (PMID:17015724)
Ensembl
MGI
PMID:10662804 PMID:15238604 PMID:16618598 PMID:17015724 GO_REF:0000107 NCBI chr10:49,825,330...49,838,036
Ensembl chr10:49,803,898...49,838,028
JBrowse link
G NUGGC nuclear GTPase, germinal center associated acts_upstream_of_or_within ISO (PMID:22833677) MGI PMID:22833677 NCBI chr25:29,507,198...29,561,565
Ensembl chr25:29,520,921...29,561,349
JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10429667) Ensembl
MGI
TreeGrafter
PMID:10429667 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:11,411,062...11,438,767
Ensembl chr 6:11,349,453...11,438,940
JBrowse link
G POLB DNA polymerase beta involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:24388753) Ensembl
MGI
PMID:24388753 GO_REF:0000107 NCBI chr16:23,306,359...23,335,352
Ensembl chr16:23,306,367...23,335,322
JBrowse link
G POLM DNA polymerase mu acts_upstream_of_or_within ISO (PMID:15789338) MGI PMID:15789338
G POLQ DNA polymerase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:24,713,174...24,837,113
Ensembl chr33:24,714,086...24,837,402
JBrowse link
G SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:25,623,997...25,676,336
Ensembl chr24:25,626,134...25,680,902
JBrowse link
G UNG uracil DNA glycosylase acts_upstream_of_or_within ISO (PMID:17015724)
(PMID:15494304)
MGI PMID:15494304 PMID:17015724 NCBI chr26:17,900,354...17,911,126
Ensembl chr26:17,901,357...17,911,288
JBrowse link
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11828012) Ensembl
MGI
PMID:11828012 GO_REF:0000107 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15494304)
(PMID:11828012)
(PMID:14568978)
(PMID:14563316), (PMID:15955838)
Ensembl
MGI
PMID:11828012 PMID:14563316 PMID:14568978 PMID:15494304 PMID:15955838 GO_REF:0000107 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210
JBrowse link
G MSH3 mutS homolog 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15238604) TreeGrafter
MGI
PMID:15238604 GO_REF:0000118 NCBI chr 3:26,335,788...26,520,633
Ensembl chr 3:26,336,403...26,518,521
JBrowse link
G MSH6 mutS homolog 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15238604) Ensembl
MGI
PMID:15238604 GO_REF:0000107 NCBI chr10:49,825,330...49,838,036
Ensembl chr10:49,803,898...49,838,028
JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11828012) Ensembl
MGI
PMID:11828012 GO_REF:0000107 NCBI chr 6:11,411,062...11,438,767
Ensembl chr 6:11,349,453...11,438,940
JBrowse link
G UNG uracil DNA glycosylase acts_upstream_of_or_within ISO (PMID:15494304) MGI PMID:15494304 NCBI chr26:17,900,354...17,911,126
Ensembl chr26:17,901,357...17,911,288
JBrowse link
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12743174) Ensembl
MGI
PMID:12743174 GO_REF:0000107 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12743174) Ensembl
MGI
TreeGrafter
PMID:12743174 GO_REF:0000107 GO_REF:0000118 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210
JBrowse link
T cell receptor V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL11B BCL11 transcription factor B involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12717433) Ensembl
MGI
PMID:12717433 GO_REF:0000107 NCBI chr 8:67,622,592...67,713,922
Ensembl chr 8:67,622,708...67,714,404
JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9462507) Ensembl
MGI
PMID:9462507 GO_REF:0000107 NCBI chr32:28,516,002...28,633,759
Ensembl chr32:28,517,108...28,634,019
JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10911993) Ensembl
MGI
PMID:10911993 GO_REF:0000107 NCBI chr22:56,980,333...56,987,636
Ensembl chr22:56,980,622...56,983,357
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO (PMID:9768755) MGI PMID:9768755 NCBI chr29:24,904...243,926
Ensembl chr29:35,007...243,895
JBrowse link
G TCF7 transcription factor 7 acts_upstream_of_or_within ISO (PMID:9462507) MGI PMID:9462507 NCBI chr11:22,313,113...22,346,221
Ensembl chr11:22,313,105...22,344,004
JBrowse link
V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23836881) Ensembl
MGI
PMID:23836881 GO_REF:0000107 NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207
JBrowse link
G DCAF1 DDB1 and CUL4 associated factor 1 involved_in ISO (MGI:5314150|PMID:22157821) UniProt PMID:22157821 MGI:5314150 NCBI chr20:38,109,974...38,187,621
Ensembl chr20:38,125,078...38,187,107
JBrowse link
G DCLRE1C DNA cross-link repair 1C involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23836881) Ensembl
MGI
PMID:23836881 GO_REF:0000107 NCBI chr 2:21,688,822...21,725,021
Ensembl chr 2:21,688,766...21,724,248
JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:9166431) UniProt PMID:9166431 NCBI chr25:9,431,223...9,558,167
Ensembl chr25:9,431,218...9,558,165
JBrowse link
G LIG1 DNA ligase 1 NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chr 1:108,105,523...108,143,954
Ensembl chr 1:108,105,987...108,143,953
JBrowse link
G LIG3 DNA ligase 3 NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chr 9:38,346,275...38,366,634
Ensembl chr 9:38,346,199...38,366,193
JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10716994)
(PMID:15194694)
Ensembl
MGI
PMID:10716994 PMID:15194694 GO_REF:0000107 NCBI chr22:56,980,333...56,987,636
Ensembl chr22:56,980,622...56,983,357
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO (PMID:23836881) MGI PMID:23836881 NCBI chr29:24,904...243,926
Ensembl chr29:35,007...243,895
JBrowse link
G RAG1 recombination activating 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:2360047) UniProt
MGI
TreeGrafter
Ensembl
InterPro
PMID:2360047 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr18:31,628,231...31,639,980
Ensembl chr18:31,630,737...31,641,660
JBrowse link
G RAG2 recombination activating 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:2360047) Ensembl
MGI
TreeGrafter
PMID:2360047 GO_REF:0000107 GO_REF:0000118 NCBI chr18:31,614,143...31,621,489
Ensembl chr18:31,618,481...31,620,064
JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:10716994) MGI PMID:10716994 NCBI chr 3:24,316,598...24,547,463
Ensembl chr 3:24,269,974...24,533,465
JBrowse link
G XRCC6 X-ray repair cross complementing 6 acts_upstream_of_or_within ISO (PMID:10716994) MGI PMID:10716994 NCBI chr10:23,637,905...23,661,618
Ensembl chr10:23,638,237...23,661,480
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    immune system process 2495
      somatic diversification of immune receptors 88
        somatic diversification of DSCAM-based immune receptors 0
        somatic diversification of FREP-based immune receptors 0
        somatic diversification of T cell receptor genes + 5
        somatic diversification of immune receptors by N region addition + 0
        somatic diversification of immune receptors via alternate splicing + 0
        somatic diversification of immune receptors via gene conversion + 0
        somatic diversification of immune receptors via germline recombination within a single locus + 81
        somatic diversification of immune receptors via somatic mutation + 16
        somatic diversification of immunoglobulins + 75
        somatic diversification of variable lymphocyte receptors of jawless fish 0
Path 2
Term Annotations click to browse term
  biological_process 17917
    developmental process 6831
      anatomical structure development 6414
        multicellular organism development 5174
          system development 4502
            immune system development 236
              somatic diversification of immune receptors 88
                somatic diversification of DSCAM-based immune receptors 0
                somatic diversification of FREP-based immune receptors 0
                somatic diversification of T cell receptor genes + 5
                somatic diversification of immune receptors by N region addition + 0
                somatic diversification of immune receptors via alternate splicing + 0
                somatic diversification of immune receptors via gene conversion + 0
                somatic diversification of immune receptors via germline recombination within a single locus + 81
                somatic diversification of immune receptors via somatic mutation + 16
                somatic diversification of immunoglobulins + 75
                somatic diversification of variable lymphocyte receptors of jawless fish 0
paths to the root