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Term:MAML1-RBP-Jkappa- ICN1 complex
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Accession:GO:0002193 term browser browse the term
Definition:A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
Synonyms:exact_synonym: MAML1-CSL-ICN1;   MAML1-CSL-Notch1 complex;   MAML1-RBP-Jkappa-Notch1 complex

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MAML1-RBP-Jkappa- ICN1 complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Maml1 mastermind-like transcriptional coactivator 1 ISO (PMID:16510869) RGD PMID:16510869 NCBI chr10:35,765,196...35,801,375
Ensembl chr10:35,765,719...35,800,120
JBrowse link
G Notch1 notch receptor 1 ISO (PMID:16510869) RGD PMID:16510869 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO
RGD PMID:16510869, PMID:21873635 RGD:13792537 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
G Rbpjl2 recombination signal binding protein for immunoglobulin kappa J region-like 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:4,877,924...4,879,637
Ensembl chr 5:4,679,515...4,879,634
JBrowse link

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  cellular_component 20609
    protein-containing complex 6092
      MAML1-RBP-Jkappa- ICN1 complex 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.