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ONTOLOGY REPORT - ANNOTATIONS


Term:cytoplasmic translational initiation
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Accession:GO:0002183 term browser browse the term
Definition:The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.



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cytoplasmic translational initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2b3 eukaryotic translation initiation factor 2B subunit gamma involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:130,492,167...130,558,692
Ensembl chr 5:130,492,220...130,563,332
JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:141,935,135...141,942,589
Ensembl chr 5:141,935,044...141,942,676
JBrowse link
G Eif3m eukaryotic translation initiation factor 3, subunit M involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:54,384,345...54,389,853
Ensembl chr10:54,384,347...54,389,858
JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
JBrowse link
cap-dependent translational initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif3d eukaryotic translation initiation factor 3, subunit D involved_in ISO
ISS
(PMID:27462815)
GO_REF:0000024
RGD
UniProt
PMID:27462815 GO_REF:0000024 NCBI chr 7:109,539,795...109,552,184
Ensembl chr 7:109,539,356...109,552,206
JBrowse link
cap-independent translational initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbm4 RNA binding motif protein 4 involved_in ISO (PMID:17284590) RGD PMID:17284590 NCBI chr 1:202,078,442...202,087,506
Ensembl chr 1:202,085,279...202,105,380
JBrowse link
formation of cytoplasmic translation initiation complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A involved_in IBA
ISO
ISS
PMID:21873635
(MGI:3843422|PMID:17581632)
GO_REF:0000024
(PMID:17581632)
RGD
UniProt
PMID:17581632 PMID:21873635 GO_REF:0000024 MGI:3843422, RGD:13792537 NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976
JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886
JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
JBrowse link
G Eif3d eukaryotic translation initiation factor 3, subunit D involved_in ISO (MGI:3843422|PMID:17581632) RGD PMID:17581632 MGI:3843422 NCBI chr 7:109,539,795...109,552,184
Ensembl chr 7:109,539,356...109,552,206
JBrowse link
G Eif3el1 eukaryotic translation initiation factor 3, subunit E-like 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096
JBrowse link
G Eif3f eukaryotic translation initiation factor 3, subunit F involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:162,934,220...162,943,204
Ensembl chr 1:162,934,212...162,943,204
JBrowse link
G Eif3g eukaryotic translation initiation factor 3, subunit G involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 8:19,429,728...19,433,760
Ensembl chr 8:19,429,643...19,433,808
JBrowse link
G Eif3h eukaryotic translation initiation factor 3, subunit H involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 7:83,091,045...83,174,436
Ensembl chr 7:83,091,039...83,174,451
JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 5:141,935,135...141,942,589
Ensembl chr 5:141,935,044...141,942,676
JBrowse link
G Eif3j eukaryotic translation initiation factor 3, subunit J involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:108,985,103...109,007,341
Ensembl chr 3:108,985,118...109,007,953
JBrowse link
G Eif3k eukaryotic translation initiation factor 3, subunit K involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:84,260,125...84,270,051
Ensembl chr 1:84,259,673...84,270,302
JBrowse link
G Eif3m eukaryotic translation initiation factor 3, subunit M involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G LOC100365062 eukaryotic translation initiation factor 3, subunit 6 48kDa-like involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:73,774,491...73,775,984
Ensembl chr 1:73,774,487...73,776,003
JBrowse link
G NEWGENE_619861 eukaryotic translation initiation factor 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:130,589,200...130,597,656 JBrowse link
formation of translation preinitiation complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Denr density regulated reinitiation and release factor involved_in ISO
IBA
(PMID:20713520)
PMID:21873635
RGD PMID:20713520 PMID:21873635 RGD:13792537 NCBI chr12:32,662,512...32,685,283
Ensembl chr12:32,662,516...32,683,843
JBrowse link
G Dhx29 DExH-box helicase 29 involved_in ISO (PMID:23047696) RGD PMID:23047696 NCBI chr 2:44,560,653...44,611,450
Ensembl chr 2:44,560,714...44,611,445
JBrowse link
G Eif2d eukaryotic translation initiation factor 2D involved_in IBA
ISO
PMID:21873635
(PMID:20713520)
RGD PMID:20713520 PMID:21873635 RGD:13792537 NCBI chr13:42,615,901...42,637,107
Ensembl chr13:42,615,911...42,639,719
JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
JBrowse link
G Eif2s3 eukaryotic translation initiation factor 2 subunit gamma involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:58,916,513...58,939,923
Ensembl chr  X:58,917,490...58,940,686
JBrowse link
G Eif2s3y eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  Y:869,654...889,341
Ensembl chr  Y:869,689...889,340
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:133,206,637...133,228,436 JBrowse link
G Eif4h eukaryotic translation initiation factor 4H involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:22,083,155...22,099,876
Ensembl chr12:22,082,835...22,099,876
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 involved_in IDA
IBA
IMP
PMID:21873635 RGD
GO_Central
PMID:8464924 PMID:21873635 PMID:10805737 RGD:728212, RGD:13792537, RGD:10755758
G Mcts1 MCTS1, re-initiation and release factor involved_in ISO
IBA
(PMID:20713520)
PMID:21873635
RGD PMID:20713520 PMID:21873635 RGD:13792537 NCBI chr  X:117,350,723...117,362,504
Ensembl chr  X:117,350,889...117,362,504
JBrowse link
G NEWGENE_619861 eukaryotic translation initiation factor 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:130,589,200...130,597,656 JBrowse link
G Rps2 ribosomal protein S2 IMP RGD PMID:344063 RGD:2299070 NCBI chr10:13,747,316...13,749,165
Ensembl chr10:13,747,301...13,749,163
JBrowse link
IRES-dependent translational initiation of linear mRNA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 involved_in ISO (MGI:5558956|PMID:24553947) RGD PMID:24553947 MGI:5558956 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Rbm4 RNA binding motif protein 4 involved_in ISO (PMID:17284590) RGD PMID:17284590 NCBI chr 1:202,078,442...202,087,506
Ensembl chr 1:202,085,279...202,105,380
JBrowse link
negative regulation of formation of translation preinitiation complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl13a ribosomal protein L13A involved_in ISO
ISS
(PMID:17218275)
GO_REF:0000024
RGD
UniProt
PMID:17218275 GO_REF:0000024 NCBI chr 1:95,609,374...95,612,557 JBrowse link
positive regulation of cap-dependent translational initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:11959995) RGD PMID:11959995 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300
JBrowse link
positive regulation of cap-independent translational initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mettl3 methyltransferase-like 3 involved_in ISO (PMID:26593424) RGD PMID:26593424 NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041
JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:11959995) RGD PMID:11959995 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300
JBrowse link
G Ythdf2 YTH N(6)-methyladenosine RNA binding protein 2 involved_in ISO (PMID:26458103) RGD PMID:26458103 NCBI chr 5:144,381,426...144,407,126
Ensembl chr 5:144,381,431...144,408,144
JBrowse link
translation reinitiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Denr density regulated reinitiation and release factor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:32,662,512...32,685,283
Ensembl chr12:32,662,516...32,683,843
JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976
JBrowse link
G Mcts1 MCTS1, re-initiation and release factor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:117,350,723...117,362,504
Ensembl chr  X:117,350,889...117,362,504
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    cellular process 18252
      cellular metabolic process 10656
        translational initiation 125
          cytoplasmic translational initiation 34
            cap-dependent translational initiation + 2
            cap-independent translational initiation + 5
            formation of cytoplasmic translation initiation complex 16
            formation of translation preinitiation complex + 13
            negative regulation of cytoplasmic translational initiation + 1
            positive regulation of cytoplasmic translational initiation + 3
            regulation of cytoplasmic translational initiation + 4
            translation reinitiation 3
Path 2
Term Annotations click to browse term
  biological_process 19390
    cellular process 18252
      cellular metabolic process 10656
        cellular nitrogen compound metabolic process 6503
          cellular nitrogen compound biosynthetic process 4846
            amide biosynthetic process 1183
              peptide biosynthetic process 1064
                translation 1044
                  cytoplasmic translation 225
                    cytoplasmic translational initiation 34
                      cap-dependent translational initiation + 2
                      cap-independent translational initiation + 5
                      formation of cytoplasmic translation initiation complex 16
                      formation of translation preinitiation complex + 13
                      negative regulation of cytoplasmic translational initiation + 1
                      positive regulation of cytoplasmic translational initiation + 3
                      regulation of cytoplasmic translational initiation + 4
                      translation reinitiation 3
paths to the root