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ONTOLOGY REPORT - ANNOTATIONS

Term:cytoplasmic translational initiation
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Accession:GO:0002183 term browser browse the term
Definition:The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.


show annotations for term's descendants           Sort by:
cytoplasmic translational initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2b1 eukaryotic translation initiation factor 2B subunit alpha involved_in ISS
ISO
IEA		 PMID:27023709
(PMID:27023709)
GO_REF:0000107		 RGD
Ensembl		 PMID:27023709 PMID:27023709 GO_REF:0000107, RGD:401901212 NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601 		JBrowse link
G Eif2b2 eukaryotic translation initiation factor 2B subunit beta involved_in ISS
ISO
IEA		 PMID:27023709
(PMID:27023709)
GO_REF:0000107		 RGD
Ensembl		 PMID:27023709 PMID:27023709 GO_REF:0000107, RGD:401901212 NCBI chr 6:104,866,926...104,873,351
Ensembl chr 6:104,866,753...104,873,353 		JBrowse link
G Eif2b3 eukaryotic translation initiation factor 2B subunit gamma involved_in IEA
IBA
ISO
ISS		 GO_REF:0000107
GO_REF:0000033
(PMID:27023709)		 Ensembl
GO_Central
RGD		 PMID:27023709 PMID:27023709 GO_REF:0000033 GO_REF:0000107, RGD:401901212 NCBI chr 5:130,492,167...130,558,692
Ensembl chr 5:130,492,220...130,563,332 		JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:27023709)		 Ensembl
RGD		 PMID:27023709 PMID:27023709 GO_REF:0000107, RGD:401901212 NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829 		JBrowse link
G Eif2b5 eukaryotic translation initiation factor 2B subunit epsilon involved_in ISS
ISO		 PMID:27023709
(PMID:27023709)		 RGD PMID:27023709 PMID:27023709 RGD:401901212 NCBI chr11:80,394,433...80,404,468
Ensembl chr11:80,394,433...80,404,419 		JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta involved_in ISO (PMID:31836389) RGD PMID:31836389 NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432 		JBrowse link
G Eif2s3 eukaryotic translation initiation factor 2 subunit gamma involved_in ISS
ISO		 PMID:31836389
(PMID:31836389)		 RGD PMID:31836389 PMID:31836389 RGD:401901229 NCBI chr  X:58,916,513...58,939,923
Ensembl chr  X:58,917,490...58,940,686 		JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:141,935,135...141,942,589
Ensembl chr 5:141,935,044...141,942,676 		JBrowse link
G Eif3m eukaryotic translation initiation factor 3, subunit M involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392 		JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 involved_in ISO
IBA		 (PMID:34731628)
GO_REF:0000033		 RGD
GO_Central		 PMID:34731628 GO_REF:0000033 NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858 		JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781 		JBrowse link
cap-dependent translational initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif3d eukaryotic translation initiation factor 3, subunit D involved_in ISO
IEA
ISS		 (PMID:27462815)
GO_REF:0000104
GO_REF:0000024		 RGD
UniProt		 PMID:27462815 GO_REF:0000024 GO_REF:0000104 NCBI chr 7:109,539,795...109,552,184
Ensembl chr 7:109,539,356...109,552,206 		JBrowse link
G Mif4gd MIF4G domain containing involved_in ISO (PMID:18025107) RGD PMID:18025107 NCBI chr10:100,847,168...100,852,166 JBrowse link
G Slbp stem-loop histone mRNA binding protein involved_in ISO (PMID:18025107) RGD PMID:18025107 NCBI chr14:77,071,441...77,081,911
Ensembl chr14:77,071,632...77,081,906 		JBrowse link
cap-independent translational initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbm4 RNA binding motif protein 4 involved_in ISO (PMID:17284590) RGD PMID:17284590 NCBI chr 1:202,078,442...202,087,506
Ensembl chr 1:202,085,279...202,105,380 		JBrowse link
formation of cytoplasmic translation initiation complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif3a eukaryotic translation initiation factor 3, subunit A involved_in ISO
IBA
IEA
ISS		 (PMID:17581632)
GO_REF:0000033
GO_REF:0000104
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:17581632 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976 		JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886 		JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493 		JBrowse link
G Eif3d eukaryotic translation initiation factor 3, subunit D involved_in IEA
ISO		 GO_REF:0000104
(PMID:17581632)		 UniProt
RGD		 PMID:17581632 GO_REF:0000104 NCBI chr 7:109,539,795...109,552,184
Ensembl chr 7:109,539,356...109,552,206 		JBrowse link
G Eif3e eukaryotic translation initiation factor 3 subunit E involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096 		JBrowse link
G Eif3el1 eukaryotic translation initiation factor 3, subunit E like 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:73,774,491...73,775,984
Ensembl chr 1:73,774,487...73,776,003 		JBrowse link
G Eif3f eukaryotic translation initiation factor 3, subunit F involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:162,934,220...162,943,204
Ensembl chr 1:162,934,212...162,943,204 		JBrowse link
G Eif3g eukaryotic translation initiation factor 3, subunit G involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 8:19,429,728...19,433,760
Ensembl chr 8:19,429,643...19,433,808 		JBrowse link
G Eif3h eukaryotic translation initiation factor 3, subunit H involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 7:83,091,037...83,174,451
Ensembl chr 7:83,091,039...83,174,451 		JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 5:141,935,135...141,942,589
Ensembl chr 5:141,935,044...141,942,676 		JBrowse link
G Eif3j eukaryotic translation initiation factor 3, subunit J involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:108,985,103...109,007,341
Ensembl chr 3:108,985,118...109,007,953 		JBrowse link
G Eif3k eukaryotic translation initiation factor 3, subunit K involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:84,260,127...84,270,051
Ensembl chr 1:84,259,673...84,270,302 		JBrowse link
G Eif3l eukaryotic translation initiation factor 3, subunit L involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 7:110,652,565...110,663,614
Ensembl chr 7:110,627,107...110,663,614 		JBrowse link
G Eif3m eukaryotic translation initiation factor 3, subunit M involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392 		JBrowse link
G Eif5 eukaryotic translation initiation factor 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656 		JBrowse link
formation of translation preinitiation complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Denr density regulated reinitiation and release factor involved_in ISO
IBA		 (PMID:20713520)
GO_REF:0000033		 RGD
GO_Central		 PMID:20713520 GO_REF:0000033 NCBI chr12:32,662,512...32,685,283
Ensembl chr12:32,662,516...32,683,843 		JBrowse link
G Dhx29 DExH-box helicase 29 involved_in ISO (PMID:23047696) RGD PMID:23047696 NCBI chr 2:44,560,653...44,611,450
Ensembl chr 2:44,560,714...44,611,445 		JBrowse link
G Eif2d eukaryotic translation initiation factor 2D involved_in ISO
IBA
IEA		 (PMID:20713520)
GO_REF:0000033
GO_REF:0000002		 RGD
GO_Central
InterPro		 PMID:20713520 GO_REF:0000002 GO_REF:0000033 NCBI chr13:42,615,901...42,637,107
Ensembl chr13:42,615,911...42,639,719 		JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432 		JBrowse link
G Eif2s3 eukaryotic translation initiation factor 2 subunit gamma involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:58,916,513...58,939,923
Ensembl chr  X:58,917,490...58,940,686 		JBrowse link
G Eif2s3y eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  Y:869,654...889,341
Ensembl chr  Y:869,689...889,340 		JBrowse link
G Eif5 eukaryotic translation initiation factor 5 IDA
IMP		 RGD PMID:8464924 PMID:10805737 RGD:728212, RGD:10755758 NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656 		JBrowse link
G Mcts1 MCTS1, re-initiation and release factor involved_in ISO
IBA
IEA		 (PMID:20713520)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:20713520 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:117,350,723...117,362,504
Ensembl chr  X:117,350,889...117,362,504 		JBrowse link
G Rps2 ribosomal protein S2 IMP RGD PMID:344063 RGD:2299070 NCBI chr10:13,747,316...13,749,165
Ensembl chr10:13,747,301...13,749,163 		JBrowse link
IRES-dependent translational initiation of linear mRNA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:24553947)		 Ensembl
RGD		 PMID:24553947 GO_REF:0000107 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Rbm4 RNA binding motif protein 4 involved_in ISO (PMID:17284590) RGD PMID:17284590 NCBI chr 1:202,078,442...202,087,506
Ensembl chr 1:202,085,279...202,105,380 		JBrowse link
negative regulation of formation of translation preinitiation complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl13a ribosomal protein L13A involved_in ISO
ISS		 (PMID:17218275)
GO_REF:0000024		 RGD
UniProt		 PMID:17218275 GO_REF:0000024 NCBI chr 1:95,609,374...95,612,557
Ensembl chr 1:95,609,370...95,620,463 		JBrowse link
positive regulation of cap-dependent translational initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt2 AKT serine/threonine kinase 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:23444369)		 UniProt
Ensembl
RGD		 PMID:23444369 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:11959995) RGD PMID:11959995 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Pkp1 plakophilin 1 involved_in ISO (PMID:23444369) RGD PMID:23444369 NCBI chr13:47,309,607...47,357,432
Ensembl chr13:47,309,614...47,357,465 		JBrowse link
positive regulation of cap-independent translational initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit involved_in ISO (PMID:26593424) RGD PMID:26593424 NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:11959995) RGD PMID:11959995 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Ythdf2 YTH N6-methyladenosine RNA binding protein F2 involved_in ISO (PMID:26458103) RGD PMID:26458103 NCBI chr 5:144,381,426...144,407,126
Ensembl chr 5:144,381,431...144,408,144 		JBrowse link
positive regulation of cytoplasmic translational initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sh3bgrl1 SH3 domain binding glutamate rich protein like 1 involved_in ISO (PMID:34331014) RGD PMID:34331014 NCBI chr  X:74,167,029...74,263,783
Ensembl chr  X:74,166,871...74,263,783 		JBrowse link
regulation of cytoplasmic translational initiation in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISO (PMID:24333428) RGD PMID:24333428 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630 		JBrowse link
G Impact impact RWD domain protein involved_in ISS
ISO		 GO_REF:0000024
(PMID:24333428)		 UniProt
RGD		 PMID:24333428 GO_REF:0000024 NCBI chr18:4,108,872...4,147,571
Ensembl chr18:4,108,853...4,147,569 		JBrowse link
translation reinitiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Denr density regulated reinitiation and release factor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:32,662,512...32,685,283
Ensembl chr12:32,662,516...32,683,843 		JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976 		JBrowse link
G Mcts1 MCTS1, re-initiation and release factor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:37875108)		 UniProt
Ensembl
RGD		 PMID:37875108 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:117,350,723...117,362,504
Ensembl chr  X:117,350,889...117,362,504 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        translational initiation 133
          cytoplasmic translational initiation 43
            cap-dependent translational initiation + 6
            cap-independent translational initiation + 5
            formation of cytoplasmic translation initiation complex 15
            formation of translation preinitiation complex + 10
            negative regulation of cytoplasmic translational initiation + 1
            positive regulation of cytoplasmic translational initiation + 6
            regulation of cytoplasmic translational initiation + 9
            translation reinitiation 3
Path 2
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        biosynthetic process 8474
          macromolecule biosynthetic process 7498
            gene expression 7054
              translation 1163
                translational initiation 133
                  cytoplasmic translational initiation 43
                    cap-dependent translational initiation + 6
                    cap-independent translational initiation + 5
                    formation of cytoplasmic translation initiation complex 15
                    formation of translation preinitiation complex + 10
                    negative regulation of cytoplasmic translational initiation + 1
                    positive regulation of cytoplasmic translational initiation + 6
                    regulation of cytoplasmic translational initiation + 9
                    translation reinitiation 3
paths to the root