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ONTOLOGY REPORT - ANNOTATIONS

Term:3-methylcrotonyl-CoA carboxylase complex, mitochondrial
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Accession:GO:0002169 term browser browse the term
Definition:A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA.
Synonyms:exact_synonym: mitochondrial 3-methylcrotonyl-CoA carboxylase holoenzyme;   mitochondrial MCCC complex;   mitochondrial methylcrotonoyl-CoA carboxylase complex


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3-methylcrotonyl-CoA carboxylase complex, mitochondrial term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MCCC1 methylcrotonyl-CoA carboxylase subunit 1 located_in
part_of		 IPI
TAS
NAS		 (PMID:17360195)
(PMID:22869039)
(PMID:11170888), (PMID:11181649), (PMID:11401427)		 ComplexPortal
ParkinsonsUK-UCL		 PMID:11170888 PMID:11181649 PMID:11401427 PMID:17360195 PMID:22869039 NCBI chr 3:183,015,218...183,116,196
Ensembl chr 3:183,015,218...183,116,075 		JBrowse link
G MCCC2 methylcrotonyl-CoA carboxylase subunit 2 located_in
part_of		 IPI
NAS
TAS		 (PMID:17360195)
(PMID:11170888), (PMID:11181649)
(PMID:22869039)		 ComplexPortal
ParkinsonsUK-UCL		 PMID:11170888 PMID:11181649 PMID:17360195 PMID:22869039 NCBI chr 5:71,587,340...71,658,706
Ensembl chr 5:71,579,531...71,658,706 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20709
    protein-containing complex 7387
      mitochondrial protein-containing complex 313
        3-methylcrotonyl-CoA carboxylase complex, mitochondrial 2
Path 2
Term Annotations click to browse term
  cellular_component 20709
    cellular anatomical entity 20317
      intracellular anatomical structure 16154
        intracellular organelle 14500
          intracellular membrane-bounded organelle 13318
            mitochondrion 1764
              mitochondrial protein-containing complex 313
                3-methylcrotonyl-CoA carboxylase complex, mitochondrial 2
paths to the root