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ONTOLOGY REPORT - ANNOTATIONS

Term:retinoic acid biosynthetic process
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Accession:GO:0002138 term browser browse the term
Definition:The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
Synonyms:exact_synonym: retinoic acid anabolic process;   retinoic acid biosynthesis

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retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family member A1 ISO RGD PMID:21138835 RGD:6771354 NCBI chrNW_004936503:8,869,073...8,953,726
Ensembl chrNW_004936503:8,868,961...8,918,532 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family member A2 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15950969 PMID:21138835 GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chrNW_004936471:19,175,997...19,263,335
Ensembl chrNW_004936471:19,175,992...19,263,335 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family member A3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11013254), (PMID:11044606), (PMID:16241904) RGD
MGI
Ensembl		 PMID:11013254 PMID:11044606 PMID:15950969 PMID:16241904 PMID:21138835 GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chrNW_004936483:2,930,781...2,967,309
Ensembl chrNW_004936483:2,930,789...2,967,346 		JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 ISO RGD PMID:15950969 RGD:6771322 NCBI chrNW_004936580:5,861,051...5,866,818
Ensembl chrNW_004936580:5,860,562...5,866,856 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 ISO RGD PMID:15950969 PMID:21138835 RGD:6771322 RGD:6771354 NCBI chrNW_004936469:10,465,701...10,487,534
Ensembl chrNW_004936469:10,465,701...10,487,534 		JBrowse link
G Rbp1 retinol binding protein 1 involved_in ISO
IEA		 RGD
InterPro		 PMID:15950969 GO_REF:0000002 RGD:6771322 NCBI chrNW_004936540:1,600,673...1,626,573
Ensembl chrNW_004936540:1,600,398...1,626,652 		JBrowse link
G Rdh10 retinol dehydrogenase 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17473173) Ensembl
MGI		 PMID:17473173 GO_REF:0000107 NCBI chrNW_004936648:2,060,131...2,088,021
Ensembl chrNW_004936648:2,060,125...2,088,833 		JBrowse link
9-cis-retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family member A1 acts_upstream_of_or_within ISO (PMID:11876656) MGI PMID:11876656 NCBI chrNW_004936503:8,869,073...8,953,726
Ensembl chrNW_004936503:8,868,961...8,918,532 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family member A2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11876656) Ensembl
MGI		 PMID:11876656 GO_REF:0000107 NCBI chrNW_004936471:19,175,997...19,263,335
Ensembl chrNW_004936471:19,175,992...19,263,335 		JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family member A1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11876656) Ensembl
MGI		 PMID:11876656 GO_REF:0000107 NCBI chrNW_004936560:2,562,394...2,580,261
Ensembl chrNW_004936560:2,562,748...2,580,201 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:10,465,701...10,487,534
Ensembl chrNW_004936469:10,465,701...10,487,534 		JBrowse link
G LOC101969148 cytochrome P450 1A1 ISO 9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal RGD PMID:8765131 RGD:2306683 NCBI chrNW_004936471:33,682,730...33,688,332
Ensembl chrNW_004936471:33,682,730...33,688,332 		JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prmt3 protein arginine methyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936654:1,336,546...1,464,959
Ensembl chrNW_004936654:1,336,429...1,461,476 		JBrowse link
positive regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101965278 retinol dehydrogenase 16 ISO RGD PMID:21138835 RGD:6771354 NCBI chrNW_004936646:1,195,200...1,200,778
Ensembl chrNW_004936646:1,194,547...1,200,897 		JBrowse link
G Rdh10 retinol dehydrogenase 10 ISO RGD PMID:21138835 RGD:6771354 NCBI chrNW_004936648:2,060,131...2,088,021
Ensembl chrNW_004936648:2,060,125...2,088,833 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16121
    metabolic process 10243
      hormone metabolic process 211
        retinoic acid metabolic process 21
          retinoic acid biosynthetic process 11
            9-cis-retinoic acid biosynthetic process 5
            negative regulation of retinoic acid biosynthetic process 1
            positive regulation of retinoic acid biosynthetic process 2
            regulation of retinoic acid biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 16121
    metabolic process 10243
      primary metabolic process 9150
        lipid metabolic process 1272
          cellular lipid metabolic process 939
            isoprenoid metabolic process 91
              terpenoid metabolic process 72
                diterpenoid metabolic process 64
                  retinoid metabolic process 56
                    retinoic acid metabolic process 21
                      retinoic acid biosynthetic process 11
                        9-cis-retinoic acid biosynthetic process 5
                        negative regulation of retinoic acid biosynthetic process 1
                        positive regulation of retinoic acid biosynthetic process 2
                        regulation of retinoic acid biosynthetic process + 3
paths to the root