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ONTOLOGY REPORT - ANNOTATIONS


Term:retinoic acid biosynthetic process
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Accession:GO:0002138 term browser browse the term
Definition:The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
Synonyms:exact_synonym: retinoic acid anabolic process


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retinoic acid biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 IEP
ISO
ISS
IMP
(PMID:29240402)
GO_REF:0000024
RGD
UniProt
PMID:29240402, PMID:15950969, PMID:21138835 GO_REF:0000024, RGD:6771322, RGD:6771354 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 IEP
ISO
ISS
IEA
IMP
(MGI:1927016|PMID:11044606), (MGI:3042765|PMID:14623956), (MGI:3055622|PMID:11013254), (MGI:3692370|PMID:16241904)
GO_REF:0000024
(PMID:27759097)
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:11013254 PMID:11044606 PMID:14623956 PMID:16241904 PMID:27759097, PMID:15950969, PMID:21138835 GO_REF:0000024 GO_REF:0000107 MGI:1927016 MGI:3042765 MGI:3055622 MGI:3692370, RGD:6771322, RGD:6771354 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 IEP RGD PMID:15950969 RGD:6771322 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 IEP
IDA
RGD PMID:15950969, PMID:21138835 RGD:6771322, RGD:6771354 NCBI chr 3:55,623,671...55,645,883
Ensembl chr 3:55,623,634...55,648,325
JBrowse link
G Rbp1 retinol binding protein 1 IEP RGD PMID:15950969 RGD:6771322 NCBI chr 8:106,449,321...106,470,842
Ensembl chr 8:106,449,321...106,470,842
JBrowse link
G Rdh10 retinol dehydrogenase 10 ISO (MGI:3709664|PMID:17473173) RGD PMID:17473173 MGI:3709664 NCBI chr 5:2,605,265...2,631,905
Ensembl chr 5:2,603,505...2,632,030
JBrowse link
9-cis-retinoic acid biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 IEA
ISO
GO_REF:0000107
(MGI:2662611|PMID:11876656)
Ensembl
RGD
PMID:11876656 GO_REF:0000107 MGI:2662611 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 1:16,910,043...16,929,465
Ensembl chr 1:16,910,069...16,930,481
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IDA 9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal RGD PMID:8765131 RGD:2306683 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 ISO
ISS
(PMID:11304534)
GO_REF:0000024
RGD
UniProt
PMID:11304534 GO_REF:0000024 NCBI chr 3:55,623,671...55,645,883
Ensembl chr 3:55,623,634...55,648,325
JBrowse link
G Rdh16 retinol dehydrogenase 16 ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 7:71,058,150...71,072,685
Ensembl chr 7:70,980,422...71,072,689
JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 ISO (PMID:21851338) RGD PMID:21851338 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
positive regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rdh10 retinol dehydrogenase 10 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 5:2,605,265...2,631,905
Ensembl chr 5:2,603,505...2,632,030
JBrowse link
G Rdh16 retinol dehydrogenase 16 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 7:71,058,150...71,072,685
Ensembl chr 7:70,980,422...71,072,689
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20045
    cellular process 18859
      cellular metabolic process 11040
        cellular hormone metabolic process 135
          retinoic acid metabolic process 26
            retinoic acid biosynthetic process 11
              9-cis-retinoic acid biosynthetic process 6
              negative regulation of retinoic acid biosynthetic process 1
              positive regulation of retinoic acid biosynthetic process 2
              regulation of retinoic acid biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 20045
    metabolic process 12101
      primary metabolic process 10847
        lipid metabolic process 1377
          cellular lipid metabolic process 1022
            isoprenoid metabolic process 118
              terpenoid metabolic process 93
                diterpenoid metabolic process 83
                  retinoid metabolic process 74
                    retinoic acid metabolic process 26
                      retinoic acid biosynthetic process 11
                        9-cis-retinoic acid biosynthetic process 6
                        negative regulation of retinoic acid biosynthetic process 1
                        positive regulation of retinoic acid biosynthetic process 2
                        regulation of retinoic acid biosynthetic process + 3
paths to the root