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ONTOLOGY REPORT - ANNOTATIONS

Term:retinoic acid biosynthetic process
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Accession:GO:0002138 term browser browse the term
Definition:The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
Synonyms:exact_synonym: retinoic acid anabolic process;   retinoic acid biosynthesis


show annotations for term's descendants           Sort by:
retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 involved_in IEP
IEA
ISO
ISS
IMP 		GO_REF:0000107
(PMID:29240402), (PMID:33565183)
GO_REF:0000024 		Ensembl
RGD
UniProt		 PMID:29240402 PMID:33565183 PMID:15950969 PMID:21138835 GO_REF:0000024 GO_REF:0000107, RGD:6771322, RGD:6771354 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 acts_upstream_of_or_within
involved_in 		IEP
IEA
ISO
ISS
IMP 		GO_REF:0000107
(PMID:14623956)
(PMID:11013254), (PMID:11044606), (PMID:16241904)
(PMID:27759097)
GO_REF:0000024 		Ensembl
RGD
UniProt		 PMID:11013254 PMID:11044606 PMID:14623956 PMID:16241904 PMID:27759097 More... GO_REF:0000024 GO_REF:0000107, RGD:6771322, RGD:6771354 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 IEP RGD PMID:15950969 RGD:6771322 NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 IEP
IDA 		RGD PMID:15950969 PMID:21138835 RGD:6771322, RGD:6771354 NCBI chr 3:74,553,357...74,579,535
Ensembl chr 3:54,147,803...54,220,241 		JBrowse link
G Rbp1 retinol binding protein 1 involved_in IEP
IEA 		GO_REF:0000002 InterPro
RGD		 PMID:15950969 GO_REF:0000002, RGD:6771322 NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743 		JBrowse link
G Rdh10 retinol dehydrogenase 10 acts_upstream_of_or_within ISO
IEA 		(PMID:17473173)
GO_REF:0000107 		RGD
Ensembl		 PMID:17473173 GO_REF:0000107 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572 		JBrowse link
9-cis-retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 acts_upstream_of_or_within ISO
IEA 		(PMID:11876656)
GO_REF:0000107 		RGD
Ensembl		 PMID:11876656 GO_REF:0000107 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 acts_upstream_of_or_within ISO
IEA 		(PMID:11876656)
GO_REF:0000107 		RGD
Ensembl		 PMID:11876656 GO_REF:0000107 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 acts_upstream_of_or_within ISO
IEA 		(PMID:11876656)
GO_REF:0000107 		RGD
Ensembl		 PMID:11876656 GO_REF:0000107 NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IDA 9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal RGD PMID:8765131 RGD:2306683 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 involved_in ISO
IEA
ISS 		(PMID:11304534)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:11304534 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:74,553,357...74,579,535
Ensembl chr 3:54,147,803...54,220,241 		JBrowse link
G Rdh9 retinol dehydrogenase 9 acts_upstream_of_or_within ISO (PMID:11876656) RGD PMID:11876656 NCBI chr 7:63,642,305...63,645,149 JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 involved_in ISO (PMID:21851338) RGD PMID:21851338 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Prmt3 protein arginine methyltransferase 3 involved_in ISO
ISS 		(PMID:33495566)
GO_REF:0000024 		RGD
UniProt		 PMID:33495566 GO_REF:0000024 NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435 		JBrowse link
positive regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rdh10 retinol dehydrogenase 10 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572 		JBrowse link
G Rdh16 retinol dehydrogenase 16 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 7:63,616,711...63,625,053
Ensembl chr 7:63,597,536...63,624,124 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      metabolic process 12158
        hormone metabolic process 268
          retinoic acid metabolic process 31
            retinoic acid biosynthetic process 13
              9-cis-retinoic acid biosynthetic process 6
              negative regulation of retinoic acid biosynthetic process 2
              positive regulation of retinoic acid biosynthetic process 2
              regulation of retinoic acid biosynthetic process + 4
Path 2
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      metabolic process 12158
        primary metabolic process 10727
          lipid metabolic process 1485
            isoprenoid metabolic process 143
              terpenoid metabolic process 107
                diterpenoid metabolic process 95
                  retinoid metabolic process 87
                    retinoic acid metabolic process 31
                      retinoic acid biosynthetic process 13
                        9-cis-retinoic acid biosynthetic process 6
                        negative regulation of retinoic acid biosynthetic process 2
                        positive regulation of retinoic acid biosynthetic process 2
                        regulation of retinoic acid biosynthetic process + 4
paths to the root