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ONTOLOGY REPORT - ANNOTATIONS

Term:retinoic acid biosynthetic process
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Accession:GO:0002138 term browser browse the term
Definition:The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
Synonyms:exact_synonym: retinoic acid anabolic process;   retinoic acid biosynthesis


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retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO RGD PMID:21138835 RGD:6771354 NCBI chr 1:226,163,347...226,217,342
Ensembl chr 1:226,161,299...226,217,308 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15950969 PMID:21138835 GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chr 1:113,932,722...114,037,059
Ensembl chr 1:113,932,739...114,037,046 		JBrowse link
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11013254), (PMID:11044606), (PMID:16241904) RGD
MGI
Ensembl		 PMID:11013254 PMID:11044606 PMID:15950969 PMID:16241904 PMID:21138835 GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chr 1:139,451,080...139,491,514
Ensembl chr 1:139,451,049...139,491,511 		JBrowse link
G CRABP2 cellular retinoic acid binding protein 2 ISO RGD PMID:15950969 RGD:6771322 NCBI chr 4:93,388,198...93,393,861
Ensembl chr 4:93,388,092...93,394,155 		JBrowse link
G DHRS9 dehydrogenase/reductase 9 ISO RGD PMID:15950969 PMID:21138835 RGD:6771322 RGD:6771354 NCBI chr15:75,507,538...75,533,942
Ensembl chr15:75,507,588...75,534,481 		JBrowse link
G RBP1 retinol binding protein 1 involved_in ISO
IEA		 RGD
InterPro		 PMID:15950969 GO_REF:0000002 RGD:6771322 NCBI chr13:80,380,958...80,407,328
Ensembl chr13:80,380,962...80,407,458 		JBrowse link
G RDH10 retinol dehydrogenase 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17473173) Ensembl
MGI		 PMID:17473173 GO_REF:0000107 NCBI chr 4:62,569,877...62,600,981
Ensembl chr 4:62,569,885...62,601,439 		JBrowse link
9-cis-retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 acts_upstream_of_or_within ISO (PMID:11876656) MGI PMID:11876656 NCBI chr 1:226,163,347...226,217,342
Ensembl chr 1:226,161,299...226,217,308 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11876656) Ensembl
MGI		 PMID:11876656 GO_REF:0000107 NCBI chr 1:113,932,722...114,037,059
Ensembl chr 1:113,932,739...114,037,046 		JBrowse link
G ALDH8A1 aldehyde dehydrogenase 8 family member A1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11876656) Ensembl
MGI		 PMID:11876656 GO_REF:0000107 NCBI chr 1:29,060,682...29,083,815
Ensembl chr 1:29,060,701...29,083,143 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO 9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal RGD PMID:8765131 RGD:2306683 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775 		JBrowse link
G DHRS9 dehydrogenase/reductase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:75,507,538...75,533,942
Ensembl chr15:75,507,588...75,534,481 		JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C1 aldo-keto reductase family 1, member C1 involved_in ISO (PMID:21851338) UniProt PMID:21851338 NCBI chr10:65,580,297...65,594,998
Ensembl chr10:65,576,464...65,678,248 		JBrowse link
G PRMT3 protein arginine methyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:38,884,311...39,032,944
Ensembl chr 2:38,884,362...39,032,996 		JBrowse link
positive regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100512656 retinol dehydrogenase 16 ISO RGD PMID:21138835 RGD:6771354 NCBI chr 5:22,277,006...22,285,534
Ensembl chr 5:22,228,057...22,292,434 		JBrowse link
G RDH10 retinol dehydrogenase 10 ISO RGD PMID:21138835 RGD:6771354 NCBI chr 4:62,569,877...62,600,981
Ensembl chr 4:62,569,885...62,601,439 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17634
    metabolic process 10706
      hormone metabolic process 223
        retinoic acid metabolic process 25
          retinoic acid biosynthetic process 12
            9-cis-retinoic acid biosynthetic process 5
            negative regulation of retinoic acid biosynthetic process 2
            positive regulation of retinoic acid biosynthetic process 2
            regulation of retinoic acid biosynthetic process + 4
Path 2
Term Annotations click to browse term
  biological_process 17634
    metabolic process 10706
      primary metabolic process 9432
        lipid metabolic process 1306
          cellular lipid metabolic process 964
            isoprenoid metabolic process 101
              terpenoid metabolic process 82
                diterpenoid metabolic process 72
                  retinoid metabolic process 63
                    retinoic acid metabolic process 25
                      retinoic acid biosynthetic process 12
                        9-cis-retinoic acid biosynthetic process 5
                        negative regulation of retinoic acid biosynthetic process 2
                        positive regulation of retinoic acid biosynthetic process 2
                        regulation of retinoic acid biosynthetic process + 4
paths to the root