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ONTOLOGY REPORT - ANNOTATIONS

Term:retinoic acid biosynthetic process
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Accession:GO:0002138 term browser browse the term
Definition:The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
Synonyms:exact_synonym: retinoic acid anabolic process;   retinoic acid biosynthesis

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retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family member A1 ISO RGD PMID:21138835 RGD:6771354 NCBI chrNW_004624811:505,297...563,795
Ensembl chrNW_004624811:505,101...563,855 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family member A2 involved_in ISO (PMID:29240402)
(PMID:33565183)		 UniProt
RGD		 PMID:15950969 PMID:21138835 PMID:29240402 PMID:33565183 RGD:6771322 RGD:6771354 NCBI chrNW_004624781:13,756,469...13,845,253
Ensembl chrNW_004624781:13,756,390...13,845,479 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family member A3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11013254), (PMID:11044606), (PMID:16241904) RGD
MGI
Ensembl		 PMID:11013254 PMID:11044606 PMID:15950969 PMID:16241904 PMID:21138835 GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chrNW_004624768:3,851,361...3,885,609
Ensembl chrNW_004624768:3,851,257...3,885,609 		JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 ISO RGD PMID:15950969 RGD:6771322 NCBI chrNW_004624885:1,862,911...1,867,656
Ensembl chrNW_004624885:1,862,822...1,867,726 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 ISO RGD PMID:15950969 PMID:21138835 RGD:6771322 RGD:6771354 NCBI chrNW_004624787:6,751,787...6,776,181
Ensembl chrNW_004624787:6,758,478...6,776,238 		JBrowse link
G Rbp1 retinol binding protein 1 ISO RGD PMID:15950969 RGD:6771322 NCBI chrNW_004624730:16,091,863...16,119,591
Ensembl chrNW_004624730:16,091,863...16,119,591 		JBrowse link
G Rdh10 retinol dehydrogenase 10 acts_upstream_of_or_within ISO (PMID:17473173) MGI PMID:17473173 NCBI chrNW_004624744:17,838,047...17,868,423
Ensembl chrNW_004624744:17,837,609...17,868,431 		JBrowse link
9-cis-retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family member A1 acts_upstream_of_or_within ISO (PMID:11876656) MGI PMID:11876656 NCBI chrNW_004624811:505,297...563,795
Ensembl chrNW_004624811:505,101...563,855 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family member A2 acts_upstream_of_or_within ISO (PMID:11876656) MGI PMID:11876656 NCBI chrNW_004624781:13,756,469...13,845,253
Ensembl chrNW_004624781:13,756,390...13,845,479 		JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family member A1 acts_upstream_of_or_within ISO (PMID:11876656) MGI PMID:11876656 NCBI chrNW_004624886:2,702,328...2,721,954
Ensembl chrNW_004624886:2,702,960...2,722,357 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624787:6,751,787...6,776,181
Ensembl chrNW_004624787:6,758,478...6,776,238 		JBrowse link
G LOC101707509 cytochrome P450 1A1 ISO 9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal RGD PMID:8765131 RGD:2306683 NCBI chrNW_004627988:7...1,323 JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prmt3 protein arginine methyltransferase 3 involved_in ISO (PMID:33495566) UniProt PMID:33495566 NCBI chrNW_004624766:11,669,732...11,797,133
Ensembl chrNW_004624766:11,670,108...11,795,272 		JBrowse link
positive regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rdh10 retinol dehydrogenase 10 ISO RGD PMID:21138835 RGD:6771354 NCBI chrNW_004624744:17,838,047...17,868,423
Ensembl chrNW_004624744:17,837,609...17,868,431 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15225
    metabolic process 9677
      hormone metabolic process 194
        retinoic acid metabolic process 18
          retinoic acid biosynthetic process 10
            9-cis-retinoic acid biosynthetic process 5
            negative regulation of retinoic acid biosynthetic process 1
            positive regulation of retinoic acid biosynthetic process 1
            regulation of retinoic acid biosynthetic process + 2
Path 2
Term Annotations click to browse term
  biological_process 15225
    metabolic process 9677
      primary metabolic process 8612
        lipid metabolic process 1187
          cellular lipid metabolic process 880
            isoprenoid metabolic process 78
              terpenoid metabolic process 60
                diterpenoid metabolic process 53
                  retinoid metabolic process 45
                    retinoic acid metabolic process 18
                      retinoic acid biosynthetic process 10
                        9-cis-retinoic acid biosynthetic process 5
                        negative regulation of retinoic acid biosynthetic process 1
                        positive regulation of retinoic acid biosynthetic process 1
                        regulation of retinoic acid biosynthetic process + 2
paths to the root