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ONTOLOGY REPORT - ANNOTATIONS

Term:retinoic acid biosynthetic process
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Accession:GO:0002138 term browser browse the term
Definition:The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
Synonyms:exact_synonym: retinoic acid anabolic process;   retinoic acid biosynthesis


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retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO RGD PMID:21138835 RGD:6771354 NCBI chr 1:84,940,411...84,994,789
Ensembl chr 1:84,940,411...84,994,789 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15950969 PMID:21138835 GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chr30:23,074,432...23,170,374
Ensembl chr30:23,074,432...23,340,030 		JBrowse link
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11013254), (PMID:11044606), (PMID:16241904) RGD
MGI
Ensembl		 PMID:11013254 PMID:11044606 PMID:15950969 PMID:16241904 PMID:21138835 GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chr 3:40,130,904...40,168,686
Ensembl chr 3:40,132,726...40,168,664 		JBrowse link
G CRABP2 cellular retinoic acid binding protein 2 ISO RGD PMID:15950969 RGD:6771322 NCBI chr 7:41,277,580...41,282,158
Ensembl chr 7:41,277,644...41,281,833 		JBrowse link
G DHRS9 dehydrogenase/reductase 9 ISO RGD PMID:15950969 PMID:21138835 RGD:6771322 RGD:6771354 NCBI chr36:13,859,935...13,881,432
Ensembl chr36:13,866,959...13,880,179 		JBrowse link
G RBP1 retinol binding protein 1 involved_in ISO
IEA		 RGD
InterPro		 PMID:15950969 GO_REF:0000002 RGD:6771322 NCBI chr23:35,677,844...35,698,194
Ensembl chr23:35,679,176...35,698,363 		JBrowse link
G RDH10 retinol dehydrogenase 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17473173) Ensembl
MGI		 PMID:17473173 GO_REF:0000107 NCBI chr29:21,886,014...21,912,451
Ensembl chr29:21,885,012...21,911,303 		JBrowse link
9-cis-retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 acts_upstream_of_or_within ISO (PMID:11876656) MGI PMID:11876656 NCBI chr 1:84,940,411...84,994,789
Ensembl chr 1:84,940,411...84,994,789 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11876656) Ensembl
MGI		 PMID:11876656 GO_REF:0000107 NCBI chr30:23,074,432...23,170,374
Ensembl chr30:23,074,432...23,340,030 		JBrowse link
G ALDH8A1 aldehyde dehydrogenase 8 family member A1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11876656) Ensembl
MGI		 PMID:11876656 GO_REF:0000107 NCBI chr 1:27,672,422...27,695,029
Ensembl chr 1:27,673,024...27,694,868 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO 9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal RGD PMID:8765131 RGD:2306683 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866 		JBrowse link
G DHRS9 dehydrogenase/reductase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:13,859,935...13,881,432
Ensembl chr36:13,866,959...13,880,179 		JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) involved_in ISO (PMID:21851338) UniProt PMID:21851338 NCBI chr 2:30,661,333...30,691,283
Ensembl chr 2:30,674,558...30,690,043 		JBrowse link
G PRMT3 protein arginine methyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:42,406,327...42,530,157
Ensembl chr21:42,406,314...42,528,116 		JBrowse link
positive regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RDH10 retinol dehydrogenase 10 ISO RGD PMID:21138835 RGD:6771354 NCBI chr29:21,886,014...21,912,451
Ensembl chr29:21,885,012...21,911,303 		JBrowse link
G RDH16 retinol dehydrogenase 16 ISO RGD PMID:21138835 RGD:6771354 NCBI chr10:1,124,322...1,134,138
Ensembl chr10:1,124,320...1,130,453 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17068
    metabolic process 10855
      hormone metabolic process 210
        retinoic acid metabolic process 23
          retinoic acid biosynthetic process 12
            9-cis-retinoic acid biosynthetic process 5
            negative regulation of retinoic acid biosynthetic process 2
            positive regulation of retinoic acid biosynthetic process 2
            regulation of retinoic acid biosynthetic process + 4
Path 2
Term Annotations click to browse term
  biological_process 17068
    metabolic process 10855
      primary metabolic process 9582
        lipid metabolic process 1265
          cellular lipid metabolic process 912
            isoprenoid metabolic process 93
              terpenoid metabolic process 74
                diterpenoid metabolic process 64
                  retinoid metabolic process 56
                    retinoic acid metabolic process 23
                      retinoic acid biosynthetic process 12
                        9-cis-retinoic acid biosynthetic process 5
                        negative regulation of retinoic acid biosynthetic process 2
                        positive regulation of retinoic acid biosynthetic process 2
                        regulation of retinoic acid biosynthetic process + 4
paths to the root