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ONTOLOGY REPORT - ANNOTATIONS

Term:podosome
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Accession:GO:0002102 term browser browse the term
Definition:An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
Comment:Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
Synonyms:xref: Wikipedia:Podosome
 never_in_taxon: NCBITaxon:4751 ! Fungi

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
podosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin beta ISO RGD PMID:17111031 RGD:11541102 NCBI chrNW_004955460:10,358,100...10,361,585
Ensembl chrNW_004955460:10,356,699...10,361,585 		JBrowse link
G Actr3 actin related protein 3 ISO RGD PMID:15093736 PMID:17224451 RGD:2306207 RGD:2306209 NCBI chrNW_004955459:15,216,914...15,284,013
Ensembl chrNW_004955459:15,216,914...15,284,013 		JBrowse link
G Adam8 ADAM metallopeptidase domain 8 located_in ISO (PMID:15220135) BHF-UCL PMID:15220135 NCBI chrNW_004955477:10,894,288...10,906,961
Ensembl chrNW_004955477:10,895,446...10,907,215 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 located_in ISO (PMID:21352810) MGI PMID:21352810 NCBI chrNW_004955545:2,149,107...2,192,986
Ensembl chrNW_004955545:2,149,107...2,197,153 		JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 located_in ISO (PMID:21352810) MGI PMID:21352810 NCBI chrNW_004955461:4,813,228...5,083,548
Ensembl chrNW_004955461:4,811,069...5,133,257 		JBrowse link
G Bin2 bridging integrator 2 located_in ISO (PMID:23285027) UniProt PMID:23285027 NCBI chrNW_004955547:1,774,330...1,798,031 JBrowse link
G Ccn5 cellular communication network factor 5 located_in ISO PMID:24488697 UniProt PMID:24488697 RGD:14390054 NCBI chrNW_004955445:12,623,333...12,640,127
Ensembl chrNW_004955445:12,621,972...12,639,835 		JBrowse link
G Cd2ap CD2 associated protein is_active_in ISO (PMID:17606992) MGI PMID:17606992 NCBI chrNW_004955437:12,005,399...12,087,014
Ensembl chrNW_004955437:11,983,311...12,091,100 		JBrowse link
G Cttn cortactin located_in ISO (PMID:17893324) MGI PMID:17893324 NCBI chrNW_004955422:15,838,036...15,874,067
Ensembl chrNW_004955422:15,835,145...15,874,108 		JBrowse link
G Dbnl drebrin like located_in ISO (MGI:5487508|PMID:22303001) UniProt PMID:22303001 MGI:5487508 NCBI chrNW_004955456:7,912,827...7,924,373
Ensembl chrNW_004955456:7,912,827...7,924,787 		JBrowse link
G Dock5 dedicator of cytokinesis 5 located_in ISO (PMID:27505886) MGI PMID:27505886 NCBI chrNW_004955403:48,146,616...48,338,218
Ensembl chrNW_004955403:48,146,084...48,338,218 		JBrowse link
G Fermt3 FERM domain containing kindlin 3 located_in ISO (PMID:16876785) MGI PMID:16876785 NCBI chrNW_004955422:20,854,297...20,870,463
Ensembl chrNW_004955422:20,851,805...20,870,463 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 located_in ISO (PMID:20137952) UniProt PMID:20137952 NCBI chrNW_004955460:10,402,855...10,412,459
Ensembl chrNW_004955460:10,402,855...10,412,710 		JBrowse link
G Gsn gelsolin located_in ISO (PMID:24236012) UniProt PMID:24236012 NCBI chrNW_004955419:6,682,202...6,733,361
Ensembl chrNW_004955419:6,682,058...6,733,361 		JBrowse link
G Kif9 kinesin family member 9 located_in ISO (PMID:21119006) UniProt PMID:21119006 NCBI chrNW_004955420:24,968,757...25,011,642
Ensembl chrNW_004955420:24,968,759...25,011,642 		JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 located_in ISO (PMID:24236012) UniProt PMID:24236012 NCBI chrNW_004955518:3,815,181...3,863,440
Ensembl chrNW_004955518:3,814,840...3,891,299 		JBrowse link
G Lpxn leupaxin located_in ISO (PMID:12674328)
(MGI:5306321|PMID:12674328)		 UniProt PMID:12674328 MGI:5306321 NCBI chrNW_004955511:3,459,521...3,500,181
Ensembl chrNW_004955511:3,459,378...3,497,416 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 located_in ISO (PMID:24127566) MGI PMID:24127566 NCBI chrNW_004955556:1,593,552...1,705,543
Ensembl chrNW_004955556:1,593,494...1,665,784 		JBrowse link
G Ptpn12 protein tyrosine phosphatase non-receptor type 12 located_in ISO (MGI:5306321|PMID:12674328) UniProt PMID:12674328 MGI:5306321 NCBI chrNW_004955410:7,556,283...7,599,170
Ensembl chrNW_004955410:7,557,103...7,599,139 		JBrowse link
G Sh3pxd2a SH3 and PX domains 2A located_in ISO (PMID:18417249)
(MGI:6158822|PMID:12615925)		 UniProt PMID:12615925 PMID:18417249 MGI:6158822 NCBI chrNW_004955485:6,811,857...7,008,011
Ensembl chrNW_004955485:6,811,844...7,009,432 		JBrowse link
G Sh3pxd2b SH3 and PX domains 2B located_in ISO (MGI:4365313|PMID:19669234), (MGI:4943661|PMID:19144821) UniProt PMID:19144821 PMID:19669234 MGI:4365313 MGI:4943661 NCBI chrNW_004955408:25,103,278...25,169,934
Ensembl chrNW_004955408:25,103,278...25,170,003 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase located_in ISO (PMID:17893324) MGI PMID:17893324 NCBI chrNW_004955445:19,213,210...19,227,670
Ensembl chrNW_004955445:19,215,161...19,228,695 		JBrowse link
G Tns3 tensin 3 located_in ISO (PMID:27505886) MGI PMID:27505886 NCBI chrNW_004955456:5,671,688...5,812,039
Ensembl chrNW_004955456:5,717,142...5,812,291 		JBrowse link
G Tpm3 tropomyosin 3 located_in ISO (PMID:16765662) MGI PMID:16765662 NCBI chrNW_004955545:715,860...746,580
Ensembl chrNW_004955545:715,280...746,575 		JBrowse link
G Tpm4 tropomyosin 4 located_in ISO (PMID:16765662) MGI PMID:16765662 NCBI chrNW_004955524:1,419,061...1,432,114
Ensembl chrNW_004955524:1,415,848...1,432,139 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 located_in ISO (PMID:15220135) BHF-UCL PMID:15220135 NCBI chrNW_004955435:5,390,745...5,410,025
Ensembl chrNW_004955435:5,390,751...5,411,691 		JBrowse link
G Vcl vinculin located_in ISO (PMID:17893324) MGI PMID:17893324 NCBI chrNW_004955437:17,812,998...17,920,253
Ensembl chrNW_004955437:17,813,007...17,920,253 		JBrowse link
podosome core term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 ISO RGD PMID:23158496 RGD:11530035 NCBI chrNW_004955424:19,293,949...19,333,170
Ensembl chrNW_004955424:19,293,949...19,333,170 		JBrowse link
G Actr3 actin related protein 3 ISO RGD PMID:24290759 RGD:11530018 NCBI chrNW_004955459:15,216,914...15,284,013
Ensembl chrNW_004955459:15,216,914...15,284,013 		JBrowse link
G Arpc2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chrNW_004955453:15,117,978...15,145,895
Ensembl chrNW_004955453:15,116,093...15,146,041 		JBrowse link
podosome ring term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chrNW_004955453:15,117,978...15,145,895
Ensembl chrNW_004955453:15,116,093...15,146,041 		JBrowse link
G Vcl vinculin located_in ISO (PMID:27505886) MGI PMID:27505886 NCBI chrNW_004955437:17,812,998...17,920,253
Ensembl chrNW_004955437:17,813,007...17,920,253 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 12554
    cellular anatomical entity 12397
      intracellular anatomical structure 10515
        intracellular organelle 9421
          intracellular non-membrane-bounded organelle 3682
            podosome 29
              podosome core 3
              podosome ring 2
Path 2
Term Annotations click to browse term
  cellular_component 12554
    cellular anatomical entity 12397
      organelle 9788
        non-membrane-bounded organelle 3684
          intracellular non-membrane-bounded organelle 3682
            cytoskeleton 1694
              actin cytoskeleton 408
                podosome 29
                  podosome core 3
                  podosome ring 2
paths to the root