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ONTOLOGY REPORT - ANNOTATIONS


Term:podosome
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Accession:GO:0002102 term browser browse the term
Definition:An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
Comment:Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
Synonyms:xref: Wikipedia:Podosome
 never_in_taxon: NCBITaxon:4751 ! Fungi



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podosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta IDA RGD PMID:17111031 RGD:11541102 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Actr3 actin related protein 3 IDA RGD PMID:17224451 PMID:15093736 RGD:2306207, RGD:2306209 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124
JBrowse link
G Adam8 ADAM metallopeptidase domain 8 located_in ISO (PMID:15220135) RGD PMID:15220135 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801
JBrowse link
G Afap1l1 actin filament associated protein 1-like 1 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr18:55,183,786...55,244,174
Ensembl chr18:55,183,786...55,244,146
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 located_in ISO (MGI:5002438|PMID:21352810) RGD PMID:21352810 MGI:5002438 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355
JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 located_in
is_active_in
IEA
ISO
IBA
GO_REF:0000107
(MGI:3768569|PMID:17893324)
PMID:21873635
(MGI:5002438|PMID:21352810)
Ensembl
RGD
PMID:17893324 PMID:21352810 PMID:21873635 GO_REF:0000107 MGI:3768569 MGI:5002438, RGD:13792537 NCBI chr 7:95,786,130...96,093,111
Ensembl chr 7:95,787,818...96,092,754
JBrowse link
G Bin2 bridging integrator 2 located_in
is_active_in
ISO
IBA
ISS
(PMID:23285027)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:23285027 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 7:131,742,001...131,768,208
Ensembl chr 7:131,742,002...131,786,285
JBrowse link
G Ccn5 cellular communication network factor 5 located_in IDA PMID:24488697 UniProt PMID:24488697 RGD:14390054 NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636
JBrowse link
G Cttn cortactin located_in ISO
IEA
(MGI:3768569|PMID:17893324)
GO_REF:0000107
RGD
Ensembl
PMID:17893324 GO_REF:0000107 MGI:3768569 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
JBrowse link
G Dbnl drebrin-like located_in ISS
ISO
GO_REF:0000024
(MGI:5487508|PMID:22303001)
UniProt
RGD
PMID:22303001 GO_REF:0000024 MGI:5487508 NCBI chr14:80,666,115...80,681,155
Ensembl chr14:80,666,124...80,681,155
JBrowse link
G Fermt3 FERM domain containing kindlin 3 located_in ISO (MGI:3688938|PMID:16876785) RGD PMID:16876785 MGI:3688938 NCBI chr 1:204,189,483...204,207,683
Ensembl chr 1:204,189,484...204,207,587
JBrowse link
G Fscn1 fascin actin-bundling protein 1 located_in ISO
ISS
(PMID:20137952)
GO_REF:0000024
RGD
UniProt
PMID:20137952 GO_REF:0000024 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211
JBrowse link
G Gsn gelsolin located_in ISO (PMID:24236012) RGD PMID:24236012 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
JBrowse link
G Kif9 kinesin family member 9 located_in ISO (PMID:21119006) RGD PMID:21119006 NCBI chr 8:110,459,467...110,504,492
Ensembl chr 8:110,459,383...110,505,252
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 located_in ISO (PMID:24236012) RGD PMID:24236012 NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680
JBrowse link
G LOC100359916 heterogeneous nuclear ribonucleoprotein K-like located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 5:58,668,326...58,670,222
Ensembl chr 5:58,668,327...58,670,220
JBrowse link
G Lpxn leupaxin located_in ISO (PMID:12674328)
(MGI:5306321|PMID:12674328)
RGD PMID:12674328 MGI:5306321 NCBI chr 1:209,928,297...209,963,085
Ensembl chr 1:209,929,202...209,963,084
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 located_in ISO (MGI:5576866|PMID:24127566) RGD PMID:24127566 MGI:5576866 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Nos1ap nitric oxide synthase 1 adaptor protein located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr13:82,549,786...82,820,949
Ensembl chr13:82,530,577...82,820,949
JBrowse link
G Palld palladin, cytoskeletal associated protein IDA RGD PMID:16868024 RGD:2325783 NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337
JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 located_in ISO (MGI:5306321|PMID:12674328) RGD PMID:12674328 MGI:5306321 NCBI chr 4:14,020,997...14,092,931
Ensembl chr 4:14,021,052...14,092,927
JBrowse link
G Scin scinderin located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 6:57,110,128...57,188,059
Ensembl chr 6:57,109,403...57,188,242
JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 9:842,285...869,753
Ensembl chr 9:842,288...869,716
JBrowse link
G Sh3pxd2a SH3 and PX domains 2A located_in ISO (PMID:18417249)
(MGI:6158822|PMID:12615925)
RGD PMID:12615925 PMID:18417249 MGI:6158822 NCBI chr 1:246,153,660...246,359,806
Ensembl chr 1:246,160,502...246,360,166
JBrowse link
G Sh3pxd2b SH3 and PX domains 2B located_in ISO (MGI:4365313|PMID:19669234), (MGI:4943661|PMID:19144821) RGD PMID:19144821 PMID:19669234 MGI:4365313 MGI:4943661 NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase located_in ISO (MGI:3768569|PMID:17893324) RGD PMID:17893324 MGI:3768569 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tpm3 tropomyosin 3 located_in ISO (MGI:3688320|PMID:16765662) RGD PMID:16765662 MGI:3688320 NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013
JBrowse link
G Tpm4 tropomyosin 4 located_in ISO
IEA
(MGI:3688320|PMID:16765662)
GO_REF:0000107
RGD
Ensembl
PMID:16765662 GO_REF:0000107 MGI:3688320 NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 located_in ISO (PMID:15220135) RGD PMID:15220135 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vcl vinculin located_in IEA
ISO
GO_REF:0000107
(MGI:3768569|PMID:17893324)
Ensembl
RGD
PMID:17893324 GO_REF:0000107 MGI:3768569 NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606
JBrowse link
G Wdr1 WD repeat domain 1 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr14:72,258,032...72,291,768
Ensembl chr14:72,257,956...72,291,766
JBrowse link
podosome core term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 IDA RGD PMID:23158496 RGD:11530035 NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524
JBrowse link
G Actr3 actin related protein 3 IDA RGD PMID:24290759 RGD:11530018 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124
JBrowse link
G Arpc2 actin related protein 2/3 complex, subunit 2 IDA RGD PMID:17224451 RGD:2306207 NCBI chr 9:75,820,782...75,851,471
Ensembl chr 9:75,820,770...75,851,471
JBrowse link
podosome ring term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc2 actin related protein 2/3 complex, subunit 2 IDA RGD PMID:17224451 RGD:2306207 NCBI chr 9:75,820,782...75,851,471
Ensembl chr 9:75,820,770...75,851,471
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19307
    cellular anatomical entity 19051
      intracellular anatomical structure 14182
        intracellular organelle 12552
          intracellular non-membrane-bounded organelle 4825
            podosome 34
              podosome core 3
              podosome ring 1
Path 2
Term Annotations click to browse term
  cellular_component 19307
    cellular anatomical entity 19051
      organelle 12934
        non-membrane-bounded organelle 4826
          intracellular non-membrane-bounded organelle 4825
            cytoskeleton 2203
              actin cytoskeleton 520
                podosome 34
                  podosome core 3
                  podosome ring 1
paths to the root