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ONTOLOGY REPORT - ANNOTATIONS


Term:podosome
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Accession:GO:0002102 term browser browse the term
Definition:An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
Comment:Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
Synonyms:xref: Wikipedia:Podosome


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podosome term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta IDA RGD PMID:17111031 RGD:11541102 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Actr3 actin related protein 3 IDA RGD PMID:17224451, PMID:15093736 RGD:2306207, RGD:2306209 NCBI chr13:41,695,520...41,738,622
Ensembl chr13:41,695,183...41,738,658
JBrowse link
G Adam8 ADAM metallopeptidase domain 8 ISO (PMID:15220135) RGD PMID:15220135 NCBI chr 1:212,317,510...212,332,895
Ensembl chr 1:212,317,848...212,330,349
JBrowse link
G Afap1l1 actin filament associated protein 1-like 1 IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr18:57,052,659...57,114,589
Ensembl chr18:57,053,947...57,114,545
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 ISO (MGI:5002438|PMID:21352810) RGD PMID:21352810 MGI:5002438 NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377
JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(MGI:3768569|PMID:17893324), (MGI:5002438|PMID:21352810)
Ensembl
RGD
PMID:17893324 PMID:21352810, PMID:21873635 GO_REF:0000107 MGI:3768569 MGI:5002438, RGD:13792537 NCBI chr 7:104,670,076...104,951,090
Ensembl chr 7:104,669,672...104,801,045
JBrowse link
G Bin2 bridging integrator 2 ISO
IBA
ISS
(PMID:23285027)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:23285027, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 7:142,273,832...142,304,731
Ensembl chr 7:142,273,833...142,300,382
JBrowse link
G Ccn5 cellular communication network factor 5 IDA PMID:24488697 UniProt PMID:24488697 RGD:14390054 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
JBrowse link
G Cttn cortactin ISO (MGI:3768569|PMID:17893324) RGD PMID:17893324 MGI:3768569 NCBI chr 1:217,602,698...217,638,196
NCBI chr 1:215,255,385...215,290,882
Ensembl chr 1:217,602,698...217,638,152
Ensembl chr 1:217,602,698...217,638,152
JBrowse link
G Dbnl drebrin-like ISS
ISO
GO_REF:0000024
(MGI:5487508|PMID:22303001)
UniProt
RGD
PMID:22303001 GO_REF:0000024 MGI:5487508 NCBI chr14:86,029,335...86,044,364
Ensembl chr14:86,029,335...86,044,364
JBrowse link
G Fermt3 fermitin family member 3 ISO (MGI:3688938|PMID:16876785) RGD PMID:16876785 MGI:3688938 NCBI chr 1:222,254,183...222,272,775
Ensembl chr 1:222,254,184...222,272,285
JBrowse link
G Fscn1 fascin actin-bundling protein 1 ISO
IEA
ISS
(PMID:20137952)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20137952 GO_REF:0000024 GO_REF:0000107 NCBI chr12:13,655,459...13,668,595
Ensembl chr12:13,656,554...13,668,515
JBrowse link
G Gsn gelsolin ISO (PMID:24236012) RGD PMID:24236012 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
JBrowse link
G Kif9 kinesin family member 9 ISO (PMID:21119006) RGD PMID:21119006 NCBI chr 8:118,737,739...118,795,190
Ensembl chr 8:118,744,229...118,794,992
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 ISO (PMID:24236012) RGD PMID:24236012 NCBI chr15:57,170,566...57,277,811
Ensembl chr15:57,221,292...57,277,811
JBrowse link
G LOC100359916 heterogeneous nuclear ribonucleoprotein K-like IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 5:59,911,439...59,913,324
Ensembl chr 5:59,911,431...59,913,348
JBrowse link
G Lpxn leupaxin ISO (PMID:12674328)
(MGI:5306321|PMID:12674328)
RGD PMID:12674328 MGI:5306321 NCBI chr 1:229,642,437...229,674,129
Ensembl chr 1:229,642,412...229,674,134
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO (MGI:5576866|PMID:24127566) RGD PMID:24127566 MGI:5576866 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Palld palladin, cytoskeletal associated protein IDA RGD PMID:16868024 RGD:2325783 NCBI chr16:31,865,712...31,948,168 JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 ISO (MGI:5306321|PMID:12674328) RGD PMID:12674328 MGI:5306321 NCBI chr 4:10,631,129...10,702,390
Ensembl chr 4:10,631,073...10,702,386
JBrowse link
G Scin scinderin IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 6:59,975,375...60,055,075
Ensembl chr 6:59,976,003...60,054,279
JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 9:11,031,847...11,055,285
Ensembl chr 9:11,031,841...11,055,285
JBrowse link
G Sh3pxd2a SH3 and PX domains 2A ISO (PMID:18417249)
(MGI:6158822|PMID:12615925)
RGD PMID:12615925 PMID:18417249 MGI:6158822 NCBI chr 1:267,039,654...267,245,868
Ensembl chr 1:267,046,361...267,245,636
JBrowse link
G Sh3pxd2b SH3 and PX domains 2B ISO (MGI:4365313|PMID:19669234), (MGI:4943661|PMID:19144821) RGD PMID:19144821 PMID:19669234 MGI:4365313 MGI:4943661 NCBI chr10:17,209,152...17,296,449
Ensembl chr10:17,209,212...17,291,876
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO (MGI:3768569|PMID:17893324) RGD PMID:17893324 MGI:3768569 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tpm3 tropomyosin 3 ISO (MGI:3688320|PMID:16765662) RGD PMID:16765662 MGI:3688320 NCBI chr 2:189,423,534...189,451,340
Ensembl chr 2:189,423,559...189,451,029
JBrowse link
G Tpm4 tropomyosin 4 ISO (MGI:3688320|PMID:16765662) RGD PMID:16765662 MGI:3688320 NCBI chr16:19,385,810...19,399,851
Ensembl chr16:19,385,736...19,399,903
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO (PMID:15220135) RGD PMID:15220135 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vcl vinculin IEA
ISO
GO_REF:0000107
(MGI:3768569|PMID:17893324)
Ensembl
RGD
PMID:17893324 GO_REF:0000107 MGI:3768569 NCBI chr15:3,455,211...3,544,738
Ensembl chr15:3,455,211...3,544,702
JBrowse link
G Wdr1 WD repeat domain 1 IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr14:76,990,014...77,023,739
Ensembl chr14:76,989,919...77,023,726
JBrowse link
podosome core term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 IDA RGD PMID:23158496 RGD:11530035 NCBI chr14:104,338,486...104,375,840
Ensembl chr14:104,340,434...104,375,649
JBrowse link
G Actr3 actin related protein 3 IDA RGD PMID:24290759 RGD:11530018 NCBI chr13:41,695,520...41,738,622
Ensembl chr13:41,695,183...41,738,658
JBrowse link
G Arpc2 actin related protein 2/3 complex, subunit 2 IDA RGD PMID:17224451 RGD:2306207 NCBI chr 9:81,518,163...81,548,871
Ensembl chr 9:81,518,176...81,548,871
JBrowse link
podosome ring term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc2 actin related protein 2/3 complex, subunit 2 IDA RGD PMID:17224451 RGD:2306207 NCBI chr 9:81,518,163...81,548,871
Ensembl chr 9:81,518,176...81,548,871
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20659
    cellular anatomical entity 20354
      intracellular anatomical structure 14713
        intracellular non-membrane-bounded organelle 5342
          podosome 33
            podosome core 3
            podosome ring 1
Path 2
Term Annotations click to browse term
  cellular_component 20659
    cellular anatomical entity 20354
      intracellular anatomical structure 14713
        intracellular organelle 12520
          intracellular non-membrane-bounded organelle 5342
            cytoskeleton 2211
              actin cytoskeleton 517
                podosome 33
                  podosome core 3
                  podosome ring 1
paths to the root