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ONTOLOGY REPORT - ANNOTATIONS


Term:desensitization of G protein-coupled receptor signaling pathway by arrestin
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Accession:GO:0002032 term browser browse the term
Definition:The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins.
Synonyms:exact_synonym: arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway;   arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway;   desensitization of G-protein coupled receptor protein signaling pathway by arrestin


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desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 involved_in ISO (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chrNW_004936504:5,985,407...5,987,453 JBrowse link
G Adrb3 adrenoceptor beta 3 NOT|involved_in ISO (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chrNW_004936710:1,410,589...1,413,279 JBrowse link
G Arrb2 arrestin beta 2 involved_in ISO (PMID:12582207) RGD
UniProt
PMID:12582207 PMID:20705669 RGD:5509896 NCBI chrNW_004936677:3,173,054...3,181,475 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12170
    cellular process 11365
      signal transduction 3835
        negative regulation of signal transduction 1161
          negative adaptation of signaling pathway 27
            desensitization of G protein-coupled receptor signaling pathway 27
              desensitization of G protein-coupled receptor signaling pathway by arrestin 3
Path 2
Term Annotations click to browse term
  biological_process 12170
    biological regulation 8887
      regulation of biological process 8418
        regulation of cellular process 7986
          signal transduction 3835
            regulation of signal transduction 2557
              negative regulation of signal transduction 1161
                negative adaptation of signaling pathway 27
                  desensitization of G protein-coupled receptor signaling pathway 27
                    desensitization of G protein-coupled receptor signaling pathway by arrestin 3
paths to the root