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ONTOLOGY REPORT - ANNOTATIONS


Term:desensitization of G protein-coupled receptor signaling pathway
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Accession:GO:0002029 term browser browse the term
Definition:The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
Synonyms:exact_synonym: desensitisation of G-protein coupled receptor protein signalling pathway;   desensitization of G-protein coupled receptor protein signaling pathway


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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:3,173,054...3,181,475
Ensembl chrNW_004936677:3,172,925...3,181,520
JBrowse link
G Gipr gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chrNW_004936706:2,052,069...2,062,722
Ensembl chrNW_004936706:2,053,433...2,061,241
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:7761854)
(PMID:10338466)
MGI
Ensembl
TreeGrafter
RGD
PMID:7761854 PMID:10338466 PMID:17908240 PMID:30075183 GO_REF:0000107 GO_REF:0000118 RGD:13792694 RGD:7242040 NCBI chrNW_004936599:2,437,061...2,456,141
Ensembl chrNW_004936599:2,437,032...2,456,147
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 involved_in ISO
IEA
RGD
TreeGrafter
PMID:8381966 PMID:20837135 GO_REF:0000118 RGD:5685022 RGD:5685621 NCBI chrNW_004936657:425,902...522,331
Ensembl chrNW_004936657:426,787...521,198
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chrNW_004936486:8,720,036...8,830,472
Ensembl chrNW_004936486:8,720,036...8,831,075
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chrNW_004936597:1,706,671...1,722,370
Ensembl chrNW_004936597:1,706,665...1,722,370
JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chrNW_004936736:623,118...1,060,273
Ensembl chrNW_004936736:623,013...1,064,054
JBrowse link
G LOC101977693 lymphocyte antigen 6G6e-like involved_in IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936727:1,819,792...1,821,533 JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chrNW_004936591:1,174,364...1,250,233
Ensembl chrNW_004936591:1,174,069...1,249,410
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936528:8,005,223...8,007,586
Ensembl chrNW_004936528:8,005,189...8,007,643
JBrowse link
G Arr3 arrestin 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936762:1,194,251...1,207,914
Ensembl chrNW_004936762:1,194,166...1,208,844
JBrowse link
G Arrb1 arrestin beta 1 involved_in IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936498:4,089,621...4,172,749
Ensembl chrNW_004936498:4,094,893...4,172,755
JBrowse link
G Arrb2 arrestin beta 2 involved_in IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936677:3,173,054...3,181,475
Ensembl chrNW_004936677:3,172,925...3,181,520
JBrowse link
G Calca calcitonin related polypeptide alpha involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chrNW_004936528:3,800,801...3,806,000
Ensembl chrNW_004936528:3,800,577...3,805,004
JBrowse link
G Dnm1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chrNW_004936487:15,767,897...15,797,722
Ensembl chrNW_004936487:15,767,897...15,801,211
JBrowse link
G Dnm2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chrNW_004936659:957,408...1,046,393
Ensembl chrNW_004936659:957,392...1,049,188
JBrowse link
G Drd2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chrNW_004936612:1,094,686...1,154,149
Ensembl chrNW_004936612:1,094,680...1,154,798
JBrowse link
G Drd3 dopamine receptor D3 involved_in ISO
IEA
RGD
Ensembl
PMID:14617818 GO_REF:0000107 RGD:1581465 NCBI chrNW_004936536:1,580,732...1,616,726
Ensembl chrNW_004936536:1,580,732...1,616,725
JBrowse link
G LOC101957203 general transcription factor IIH subunit 2 involved_in ISO (PMID:15775968) UniProt PMID:15775968 NCBI chrNW_004936480:72,730...92,868 JBrowse link
G Pld2 phospholipase D2 acts_upstream_of_or_within ISO (PMID:14718562) MGI PMID:14718562 NCBI chrNW_004936677:2,870,664...2,883,545
Ensembl chrNW_004936677:2,870,660...2,883,567
JBrowse link
G Sag S-antigen visual arrestin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936525:3,932,118...3,965,651
Ensembl chrNW_004936525:3,931,933...3,964,834
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (PMID:19332541) MGI PMID:19332541 NCBI chrNW_004936478:19,183,493...19,278,457
Ensembl chrNW_004936478:19,180,726...19,278,920
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936641:3,779,024...3,802,883
Ensembl chrNW_004936641:3,779,374...3,799,581
JBrowse link
G Ubqln2 ubiquilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936819:530,833...534,185
Ensembl chrNW_004936819:532,037...533,920
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) UniProt PMID:25639753 NCBI chrNW_004936555:969,902...978,736 JBrowse link
G Apln apelin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936479:1,889,930...1,899,811
Ensembl chrNW_004936479:1,890,229...1,899,730
JBrowse link
G Aplnr apelin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:5,230,836...5,234,562
Ensembl chrNW_004936581:5,231,242...5,232,384
JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chrNW_004936640:1,549,977...1,787,436
Ensembl chrNW_004936640:1,550,167...1,787,286
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chrNW_004936591:1,174,364...1,250,233
Ensembl chrNW_004936591:1,174,069...1,249,410
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chrNW_004936591:1,174,364...1,250,233
Ensembl chrNW_004936591:1,174,069...1,249,410
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17435
    cellular process 17035
      signal transduction 5718
        negative regulation of signal transduction 1341
          negative adaptation of signaling pathway 28
            desensitization of G protein-coupled receptor signaling pathway 27
              G protein-coupled receptor internalization + 19
              inhibitory G protein-coupled receptor phosphorylation + 2
Path 2
Term Annotations click to browse term
  biological_process 17435
    biological regulation 11417
      regulation of biological process 11049
        signaling 6214
          signal transduction 5718
            regulation of signal transduction 2973
              negative regulation of signal transduction 1341
                negative adaptation of signaling pathway 28
                  desensitization of G protein-coupled receptor signaling pathway 27
                    G protein-coupled receptor internalization + 19
                    inhibitory G protein-coupled receptor phosphorylation + 2
paths to the root