Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:desensitization of G protein-coupled receptor signaling pathway
go back to main search page
Accession:GO:0002029 term browser browse the term
Definition:The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
Synonyms:exact_synonym: desensitisation of G-protein coupled receptor protein signalling pathway;   desensitization of G-protein coupled receptor protein signaling pathway



show annotations for term's descendants           Sort by:
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 involved_in ISO GO_Central GO_REF:0000119 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654
JBrowse link
G Gipr gastric inhibitory polypeptide receptor involved_in ISO
IEA
RGD
GO_Central
Ensembl
PMID:8928774 GO_REF:0000096 GO_REF:0000107 RGD:2312614 NCBI chr 7:18,889,988...18,904,173
Ensembl chr 7:18,889,986...18,900,052
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 acts_upstream_of_or_within
involved_in
ISO
IMP
IGI
IBA
(PMID:10338466)
(PMID:7761854)
RGD
MGI
GO_Central
PMID:7761854 PMID:10338466 PMID:17908240 PMID:30075183 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:13792694 RGD:7242040 NCBI chr19:4,336,029...4,356,356
Ensembl chr19:4,336,029...4,356,250
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 involved_in ISO
IBA
RGD
GO_Central
PMID:8381966 PMID:20837135 GO_REF:0000033 GO_REF:0000096 RGD:5685022 RGD:5685621 NCBI chr 5:113,058,344...113,163,518
Ensembl chr 5:113,058,348...113,163,657
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 involved_in ISO RGD
GO_Central
PMID:15166006 GO_REF:0000096 RGD:1598508 NCBI chr 5:34,817,641...34,912,649
Ensembl chr 5:34,817,723...34,912,649
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 involved_in ISO RGD
GO_Central
PMID:8626574 PMID:30075183 GO_REF:0000096 RGD:13792694 RGD:61618 NCBI chr19:60,877,995...61,084,406
Ensembl chr19:60,878,187...61,084,406
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 involved_in ISO RGD
GO_Central
PMID:12810562 PMID:17908240 GO_REF:0000096 RGD:1299124 RGD:7242040 NCBI chr13:55,592,865...55,608,740
Ensembl chr13:55,592,885...55,608,740
JBrowse link
G Grm5 glutamate receptor, metabotropic 5 involved_in IEA
ISO
Ensembl
GO_Central
GO_REF:0000096 GO_REF:0000107 NCBI chr 7:87,233,212...87,784,271
Ensembl chr 7:87,233,376...87,784,115
JBrowse link
G Ly6g6e lymphocyte antigen 6 family member G6E acts_upstream_of_or_within
involved_in
IDA
IBA
(PMID:26276394) MGI
GO_Central
PMID:26276394 GO_REF:0000033 NCBI chr17:35,295,843...35,297,781
Ensembl chr17:35,295,878...35,297,780
JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) involved_in ISO RGD
GO_Central
PMID:9350980 GO_REF:0000096 RGD:9850278 NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000107 GO_REF:0000119 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027
JBrowse link
G Arr3 arrestin 3, retinal involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:99,649,086...99,662,099
Ensembl chr  X:99,649,103...99,662,099
JBrowse link
G Arrb1 arrestin, beta 1 involved_in ISO
IBA
GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr 7:99,184,356...99,255,979
Ensembl chr 7:99,184,673...99,255,978
JBrowse link
G Arrb2 arrestin, beta 2 involved_in ISO
IEA
IBA
GO_Central
Ensembl
GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
JBrowse link
G Dnm1 dynamin 1 involved_in ISO RGD
GO_Central
PMID:14709338 GO_REF:0000096 RGD:9685157 NCBI chr 2:32,198,483...32,243,361
Ensembl chr 2:32,198,483...32,243,350
JBrowse link
G Dnm2 dynamin 2 involved_in ISO RGD
GO_Central
PMID:14709338 GO_REF:0000096 RGD:9685157 NCBI chr 9:21,336,167...21,419,055
Ensembl chr 9:21,336,204...21,419,055
JBrowse link
G Drd2 dopamine receptor D2 involved_in ISO
IEA
RGD
Ensembl
GO_Central
PMID:14617818 GO_REF:0000096 GO_REF:0000107 RGD:1581465 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
JBrowse link
G Drd3 dopamine receptor D3 involved_in ISO RGD
GO_Central
PMID:14617818 GO_REF:0000096 GO_REF:0000119 RGD:1581465 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 involved_in ISO RGD
GO_Central
PMID:12519791 GO_REF:0000096 RGD:1304268 NCBI chr 5:34,817,641...34,912,649
Ensembl chr 5:34,817,723...34,912,649
JBrowse link
G Gtf2h2 general transcription factor II H, polypeptide 2 involved_in ISO (PMID:15775968) UniProt PMID:15775968 NCBI chr13:100,596,726...100,629,123
Ensembl chr13:100,596,726...100,629,087
JBrowse link
G Pld2 phospholipase D2 acts_upstream_of_or_within IDA (PMID:14718562) MGI PMID:14718562 NCBI chr11:70,430,318...70,448,936
Ensembl chr11:70,430,890...70,448,936
JBrowse link
G Sag S-antigen, retina and pineal gland (arrestin) involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:87,731,402...87,772,880
Ensembl chr 1:87,731,402...87,772,880
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin-dependent protein kinase II, beta acts_upstream_of_or_within IDA (PMID:19332541) MGI PMID:19332541 NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in IEA
ISO
Ensembl
GO_Central
GO_REF:0000107 GO_REF:0000119 NCBI chr 8:120,173,431...120,199,379
Ensembl chr 8:120,173,458...120,199,379
JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO
ISS
GO_Central
UniProt
GO_REF:0000024 GO_REF:0000119 NCBI chr  X:152,281,228...152,284,558
Ensembl chr  X:152,281,223...152,284,566
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:65,481,069...65,489,970
Ensembl chr 8:65,481,069...65,489,988
JBrowse link
G Apln apelin involved_in ISO
IDA
(PMID:11359874) GO_Central
UniProt
PMID:11359874 GO_REF:0000096 GO_REF:0000119 NCBI chr  X:47,114,023...47,123,730
Ensembl chr  X:47,114,023...47,123,730
JBrowse link
G Aplnr apelin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:84,966,704...84,970,267
Ensembl chr 2:84,966,569...84,970,267
JBrowse link
G App amyloid beta precursor protein involved_in ISO GO_Central GO_REF:0000119 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor involved_in ISO GO_Central GO_REF:0000119 NCBI chr 2:84,966,704...84,970,267
Ensembl chr 2:84,966,569...84,970,267
JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) involved_in ISO RGD
GO_Central
PMID:15937517 GO_REF:0000096 RGD:10043344 NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 (subtype EP3) involved_in ISO RGD
GO_Central
PMID:15937517 GO_REF:0000096 RGD:10043344 NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28632
    cellular process 18393
      signal transduction 6936
        negative regulation of signal transduction 1552
          negative adaptation of signaling pathway 29
            desensitization of G protein-coupled receptor signaling pathway 28
              G protein-coupled receptor internalization + 20
              inhibitory G protein-coupled receptor phosphorylation + 3
Path 2
Term Annotations click to browse term
  biological_process 28632
    biological regulation 13455
      regulation of biological process 13012
        signaling 7520
          signal transduction 6936
            regulation of signal transduction 3429
              negative regulation of signal transduction 1552
                negative adaptation of signaling pathway 29
                  desensitization of G protein-coupled receptor signaling pathway 28
                    G protein-coupled receptor internalization + 20
                    inhibitory G protein-coupled receptor phosphorylation + 3
paths to the root