ONTOLOGY REPORT - ANNOTATIONS
Term: desensitization of G protein-coupled receptor signaling pathway
Accession: GO:0002029
browse the term
Definition: The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
Synonyms: exact_synonym: desensitisation of G-protein coupled receptor protein signalling pathway; desensitization of G-protein coupled receptor protein signaling pathway
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Arrb2
arrestin, beta 2
involved_in
ISO
GO_Central
GO_REF:0000119
NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654
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Gipr
gastric inhibitory polypeptide receptor
involved_in
ISO IEA
RGD GO_Central Ensembl
PMID:8928774
GO_REF:0000096 GO_REF:0000107 RGD:2312614
NCBI chr 7:18,889,988...18,904,173
Ensembl chr 7:18,889,986...18,900,052
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Grk2
G protein-coupled receptor kinase 2
acts_upstream_of_or_within involved_in
ISO IMP IGI IBA
(PMID:10338466) (PMID:7761854)
RGD MGI GO_Central
PMID:7761854 PMID:10338466 PMID:17908240 PMID:30075183
GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:13792694 RGD:7242040
NCBI chr19:4,336,029...4,356,356
Ensembl chr19:4,336,029...4,356,250
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Grk3
G protein-coupled receptor kinase 3
involved_in
ISO IBA
RGD GO_Central
PMID:8381966 PMID:20837135
GO_REF:0000033 GO_REF:0000096 RGD:5685022 RGD:5685621
NCBI chr 5:113,058,344...113,163,518
Ensembl chr 5:113,058,348...113,163,657
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Grk4
G protein-coupled receptor kinase 4
involved_in
ISO
RGD GO_Central
PMID:15166006
GO_REF:0000096 RGD:1598508
NCBI chr 5:34,817,641...34,912,649
Ensembl chr 5:34,817,723...34,912,649
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Grk5
G protein-coupled receptor kinase 5
involved_in
ISO
RGD GO_Central
PMID:8626574 PMID:30075183
GO_REF:0000096 RGD:13792694 RGD:61618
NCBI chr19:60,877,995...61,084,406
Ensembl chr19:60,878,187...61,084,406
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Grk6
G protein-coupled receptor kinase 6
involved_in
ISO
RGD GO_Central
PMID:12810562 PMID:17908240
GO_REF:0000096 RGD:1299124 RGD:7242040
NCBI chr13:55,592,865...55,608,740
Ensembl chr13:55,592,885...55,608,740
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Grm5
glutamate receptor, metabotropic 5
involved_in
IEA ISO
Ensembl GO_Central
GO_REF:0000096 GO_REF:0000107
NCBI chr 7:87,233,212...87,784,271
Ensembl chr 7:87,233,376...87,784,115
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Ly6g6e
lymphocyte antigen 6 family member G6E
acts_upstream_of_or_within involved_in
IDA IBA
(PMID:26276394)
MGI GO_Central
PMID:26276394
GO_REF:0000033
NCBI chr17:35,295,843...35,297,781
Ensembl chr17:35,295,878...35,297,780
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Ptger3
prostaglandin E receptor 3 (subtype EP3)
involved_in
ISO
RGD GO_Central
PMID:9350980
GO_REF:0000096 RGD:9850278
NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525
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Adm
adrenomedullin
involved_in
ISO IEA
GO_Central Ensembl
GO_REF:0000107 GO_REF:0000119
NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027
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Arr3
arrestin 3, retinal
involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr X:99,649,086...99,662,099
Ensembl chr X:99,649,103...99,662,099
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Arrb1
arrestin, beta 1
involved_in
ISO IBA
GO_Central
GO_REF:0000033 GO_REF:0000119
NCBI chr 7:99,184,356...99,255,979
Ensembl chr 7:99,184,673...99,255,978
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Arrb2
arrestin, beta 2
involved_in
ISO IEA IBA
GO_Central Ensembl
GO_REF:0000033 GO_REF:0000107 GO_REF:0000119
NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654
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Calca
calcitonin/calcitonin-related polypeptide, alpha
involved_in
ISO
(PMID:10882736)
UniProt
PMID:10882736
NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
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Dnm1
dynamin 1
involved_in
ISO
RGD GO_Central
PMID:14709338
GO_REF:0000096 RGD:9685157
NCBI chr 2:32,198,483...32,243,361
Ensembl chr 2:32,198,483...32,243,350
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Dnm2
dynamin 2
involved_in
ISO
RGD GO_Central
PMID:14709338
GO_REF:0000096 RGD:9685157
NCBI chr 9:21,336,167...21,419,055
Ensembl chr 9:21,336,204...21,419,055
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Drd2
dopamine receptor D2
involved_in
ISO IEA
RGD Ensembl GO_Central
PMID:14617818
GO_REF:0000096 GO_REF:0000107 RGD:1581465
NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
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Drd3
dopamine receptor D3
involved_in
ISO
RGD GO_Central
PMID:14617818
GO_REF:0000096 GO_REF:0000119 RGD:1581465
NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295
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Grk4
G protein-coupled receptor kinase 4
involved_in
ISO
RGD GO_Central
PMID:12519791
GO_REF:0000096 RGD:1304268
NCBI chr 5:34,817,641...34,912,649
Ensembl chr 5:34,817,723...34,912,649
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Gtf2h2
general transcription factor II H, polypeptide 2
involved_in
ISO
(PMID:15775968)
UniProt
PMID:15775968
NCBI chr13:100,596,726...100,629,123
Ensembl chr13:100,596,726...100,629,087
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Pld2
phospholipase D2
acts_upstream_of_or_within
IDA
(PMID:14718562)
MGI
PMID:14718562
NCBI chr11:70,430,318...70,448,936
Ensembl chr11:70,430,890...70,448,936
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Sag
S-antigen, retina and pineal gland (arrestin)
involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr 1:87,731,402...87,772,880
Ensembl chr 1:87,731,402...87,772,880
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Camk2b
calcium/calmodulin-dependent protein kinase II, beta
acts_upstream_of_or_within
IDA
(PMID:19332541)
MGI
PMID:19332541
NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362
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Necab2
N-terminal EF-hand calcium binding protein 2
involved_in
IEA ISO
Ensembl GO_Central
GO_REF:0000107 GO_REF:0000119
NCBI chr 8:120,173,431...120,199,379
Ensembl chr 8:120,173,458...120,199,379
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Ubqln2
ubiquilin 2
involved_in
ISO ISS
GO_Central UniProt
GO_REF:0000024 GO_REF:0000119
NCBI chr X:152,281,228...152,284,558
Ensembl chr X:152,281,223...152,284,566
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Apela
apelin receptor early endogenous ligand
involved_in
ISO
GO_Central
GO_REF:0000119
NCBI chr 8:65,481,069...65,489,970
Ensembl chr 8:65,481,069...65,489,988
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Apln
apelin
involved_in
ISO IDA
(PMID:11359874)
GO_Central UniProt
PMID:11359874
GO_REF:0000096 GO_REF:0000119
NCBI chr X:47,114,023...47,123,730
Ensembl chr X:47,114,023...47,123,730
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Aplnr
apelin receptor
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 2:84,966,704...84,970,267
Ensembl chr 2:84,966,569...84,970,267
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App
amyloid beta precursor protein
involved_in
ISO
GO_Central
GO_REF:0000119
NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
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Aplnr
apelin receptor
involved_in
ISO
GO_Central
GO_REF:0000119
NCBI chr 2:84,966,704...84,970,267
Ensembl chr 2:84,966,569...84,970,267
G
Ptger3
prostaglandin E receptor 3 (subtype EP3)
involved_in
ISO
RGD GO_Central
PMID:15937517
GO_REF:0000096 RGD:10043344
NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525
G
Ptger3
prostaglandin E receptor 3 (subtype EP3)
involved_in
ISO
RGD GO_Central
PMID:15937517
GO_REF:0000096 RGD:10043344
NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525
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