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ONTOLOGY REPORT - ANNOTATIONS


Term:desensitization of G protein-coupled receptor signaling pathway
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Accession:GO:0002029 term browser browse the term
Definition:The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
Synonyms:exact_synonym: desensitisation of G-protein coupled receptor protein signalling pathway;   desensitization of G-protein coupled receptor protein signaling pathway


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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gipr gastric inhibitory polypeptide receptor involved_in ISO RGD
MGI
PMID:8928774 GO_REF:0000096 MGI:4417868 RGD:2312614 NCBI chr 7:19,156,063...19,170,248
Ensembl chr 7:19,156,061...19,166,127
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
IGI
(MGI:1337704|PMID:10338466)
(MGI:6201960|PMID:21873635)
(MGI:84440|PMID:7761854)
MGI
GO_Central
RGD
PMID:7761854 PMID:10338466 PMID:17908240 PMID:21873635 PMID:30075183 GO_REF:0000096 MGI:1337704 MGI:4417868 MGI:4834177 MGI:6201960 MGI:84440 RGD:13792694 RGD:7242040 NCBI chr19:4,285,999...4,306,222
Ensembl chr19:4,286,001...4,306,222
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 involved_in ISO
IBA
(MGI:6201960|PMID:21873635) RGD
MGI
GO_Central
PMID:8381966 PMID:20837135 PMID:21873635 GO_REF:0000096 MGI:4417868 MGI:6201960 RGD:5685022 RGD:5685621 NCBI chr 5:112,910,478...113,015,660
Ensembl chr 5:112,910,482...113,015,791
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 involved_in ISO RGD
MGI
PMID:15166006 GO_REF:0000096 MGI:4417868 RGD:1598508 NCBI chr 5:34,660,250...34,755,305
Ensembl chr 5:34,660,379...34,755,305
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 involved_in ISO RGD
MGI
PMID:8626574 PMID:30075183 GO_REF:0000096 MGI:4417868 RGD:13792694 RGD:61618 NCBI chr19:60,889,560...61,095,968
Ensembl chr19:60,889,749...61,095,968
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 involved_in ISO RGD
MGI
PMID:12810562 PMID:17908240 GO_REF:0000096 MGI:4417868 RGD:1299124 RGD:7242040 NCBI chr13:55,445,072...55,460,927
Ensembl chr13:55,445,072...55,460,927
JBrowse link
G Grm5 glutamate receptor, metabotropic 5 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 7:87,583,981...88,135,063
Ensembl chr 7:87,584,168...88,134,907
JBrowse link
G Ly6g6e lymphocyte antigen 6 complex, locus G6E acts_upstream_of_or_within
involved_in
IDA
IBA
(MGI:5694852|PMID:26276394)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:21873635 PMID:26276394 MGI:5694852 MGI:6201960 NCBI chr17:35,076,868...35,078,804
Ensembl chr17:35,076,902...35,078,804
JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) involved_in ISO RGD
MGI
PMID:9350980 GO_REF:0000096 MGI:4417868 RGD:9850278 NCBI chr 3:157,566,821...157,644,758
Ensembl chr 3:157,566,892...157,645,888
JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenergic receptor, beta 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr18:62,177,713...62,179,981
Ensembl chr18:62,177,816...62,179,959
JBrowse link
G Adrb3 adrenergic receptor, beta 3 NOT|involved_in ISO (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chr 8:27,225,776...27,230,845
Ensembl chr 8:27,225,776...27,250,616
JBrowse link
G Arrb2 arrestin, beta 2 involved_in ISO MGI
RGD
PMID:20705669 GO_REF:0000096 MGI:4417868 MGI:4834177 RGD:5509896 NCBI chr11:70,432,485...70,440,828
Ensembl chr11:70,432,635...70,440,828
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 7:110,627,657...110,629,820
Ensembl chr 7:110,627,661...110,629,820
JBrowse link
G Arr3 arrestin 3, retinal involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr  X:100,605,480...100,618,493
Ensembl chr  X:100,605,497...100,618,493
JBrowse link
G Arrb1 arrestin, beta 1 involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr 7:99,535,147...99,606,772
Ensembl chr 7:99,535,466...99,606,771
JBrowse link
G Arrb2 arrestin, beta 2 involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr11:70,432,485...70,440,828
Ensembl chr11:70,432,635...70,440,828
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Dnm1 dynamin 1 involved_in ISO RGD
MGI
PMID:14709338 GO_REF:0000096 MGI:4417868 RGD:9685157 NCBI chr 2:32,308,471...32,353,349
Ensembl chr 2:32,308,471...32,353,338
JBrowse link
G Dnm2 dynamin 2 involved_in ISO RGD
MGI
PMID:14709338 GO_REF:0000096 MGI:4417868 RGD:9685157 NCBI chr 9:21,424,908...21,507,759
Ensembl chr 9:21,424,908...21,507,759
JBrowse link
G Drd2 dopamine receptor D2 involved_in ISO RGD
MGI
PMID:14617818 GO_REF:0000096 MGI:4417868 RGD:1581465 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177
JBrowse link
G Drd3 dopamine receptor D3 involved_in ISO MGI
RGD
PMID:14617818 GO_REF:0000096 MGI:4417868 MGI:4834177 RGD:1581465 NCBI chr16:43,754,015...43,825,982
Ensembl chr16:43,754,026...43,822,932
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 involved_in ISO RGD
MGI
PMID:12519791 GO_REF:0000096 MGI:4417868 RGD:1304268 NCBI chr 5:34,660,250...34,755,305
Ensembl chr 5:34,660,379...34,755,305
JBrowse link
G Htr1b 5-hydroxytryptamine (serotonin) receptor 1B involved_in IDA (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chr 9:81,628,291...81,633,832
Ensembl chr 9:81,628,291...81,633,828
JBrowse link
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B involved_in IDA (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chr 1:86,097,546...86,116,231
Ensembl chr 1:86,099,026...86,111,970
JBrowse link
G Pld2 phospholipase D2 acts_upstream_of_or_within IDA (MGI:3042801|PMID:14718562) MGI PMID:14718562 MGI:3042801 NCBI chr11:70,539,492...70,558,110
Ensembl chr11:70,540,064...70,558,110
JBrowse link
G Sag S-antigen, retina and pineal gland (arrestin) involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 1:87,798,143...87,845,158
Ensembl chr 1:87,803,680...87,845,158
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin-dependent protein kinase II, beta acts_upstream_of_or_within IDA (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chr11:5,969,629...6,066,357
Ensembl chr11:5,969,644...6,066,362
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 8:119,446,719...119,472,640
Ensembl chr 8:119,446,719...119,472,640
JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr  X:153,498,232...153,501,562
Ensembl chr  X:153,498,227...153,501,570
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 8:65,028,417...65,037,336
Ensembl chr 8:65,028,417...65,037,336
JBrowse link
G Apln apelin involved_in ISO
IDA
(MGI:5902690|PMID:11359874) MGI
UniProt
PMID:11359874 GO_REF:0000096 MGI:4417868 MGI:4834177 MGI:5902690 NCBI chr  X:48,025,146...48,034,853
Ensembl chr  X:48,025,146...48,034,853
JBrowse link
G App amyloid beta (A4) precursor protein involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:85,136,360...85,139,923
Ensembl chr 2:85,136,225...85,139,923
JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) involved_in ISO RGD
MGI
PMID:15937517 GO_REF:0000096 MGI:4417868 RGD:10043344 NCBI chr 3:157,566,821...157,644,758
Ensembl chr 3:157,566,892...157,645,888
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 (subtype EP3) involved_in ISO RGD
MGI
PMID:15937517 GO_REF:0000096 MGI:4417868 RGD:10043344 NCBI chr 3:157,566,821...157,644,758
Ensembl chr 3:157,566,892...157,645,888
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28599
    cellular process 17589
      signal transduction 6498
        negative regulation of signal transduction 1283
          negative adaptation of signaling pathway 31
            desensitization of G protein-coupled receptor signaling pathway 31
              G protein-coupled receptor internalization + 20
              desensitization of G protein-coupled receptor signaling pathway by arrestin 3
              inhibitory G protein-coupled receptor phosphorylation + 3
Path 2
Term Annotations click to browse term
  biological_process 28599
    biological regulation 13246
      regulation of biological process 12592
        regulation of cellular process 12028
          signal transduction 6498
            regulation of signal transduction 2986
              negative regulation of signal transduction 1283
                negative adaptation of signaling pathway 31
                  desensitization of G protein-coupled receptor signaling pathway 31
                    G protein-coupled receptor internalization + 20
                    desensitization of G protein-coupled receptor signaling pathway by arrestin 3
                    inhibitory G protein-coupled receptor phosphorylation + 3
paths to the root