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ONTOLOGY REPORT - ANNOTATIONS


Term:desensitization of G protein-coupled receptor signaling pathway
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Accession:GO:0002029 term browser browse the term
Definition:The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
Synonyms:exact_synonym: desensitisation of G-protein coupled receptor protein signalling pathway;   desensitization of G-protein coupled receptor protein signaling pathway


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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GIPR gastric inhibitory polypeptide receptor involved_in IEA
ISO
Ensembl
RGD
PMID:8928774 GO_REF:0000107 RGD:2312614 NCBI chr19:45,668,187...45,683,722
Ensembl chr19:45,668,221...45,683,722
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 involved_in
acts_upstream_of_or_within
ISS
IMP
IBA
ISO
(PMID:15102938)
(PMID:21873635)
(MGI:1337704|PMID:10338466)
(MGI:84440|PMID:7761854)
BHF-UCL
UniProt
GO_Central
MGI
RGD
PMID:7761854 PMID:10338466 PMID:15102938 PMID:17908240 PMID:21873635 PMID:30075183 GO_REF:0000024 MGI:1337704 MGI:84440 RGD:13792694 RGD:7242040 NCBI chr11:67,266,420...67,286,556
Ensembl chr11:67,266,473...67,286,556
JBrowse link
G GRK3 G protein-coupled receptor kinase 3 involved_in ISO
IBA
(PMID:21873635) RGD
GO_Central
PMID:8381966 PMID:20837135 PMID:21873635 RGD:5685022 RGD:5685621 NCBI chr22:25,564,675...25,729,294
Ensembl chr22:25,564,675...25,729,294
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chr 4:2,963,504...3,040,760
Ensembl chr 4:2,963,571...3,040,760
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chr10:119,207,571...119,459,745
Ensembl chr10:119,207,571...119,459,745
JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chr 5:177,426,496...177,442,891
Ensembl chr 5:177,403,204...177,442,901
JBrowse link
G GRM5 glutamate metabotropic receptor 5 involved_in ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr11:88,504,576...89,065,982
Ensembl chr11:88,504,576...89,065,982
JBrowse link
G LY6G6E lymphocyte antigen 6 family member G6E involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:5694852|PMID:26276394)
GO_Central
MGI
PMID:21873635 PMID:26276394 MGI:5694852 NCBI chr 6:31,711,976...31,714,065
Ensembl chr 6:31,711,771...31,714,065
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,808
JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 involved_in IDA (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623
JBrowse link
G ADRB3 adrenoceptor beta 3 NOT|involved_in IDA (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chr 8:37,962,990...37,966,599
Ensembl chr 8:37,962,990...37,966,599
JBrowse link
G ARRB2 arrestin beta 2 involved_in IMP
ISO
(PMID:12582207) UniProt
RGD
PMID:12582207 PMID:20705669 RGD:5509896 NCBI chr17:4,710,619...4,721,500
Ensembl chr17:4,710,596...4,721,499
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin involved_in IDA (PMID:10882736) UniProt PMID:10882736 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397
JBrowse link
G ARR3 arrestin 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:70,268,334...70,281,840
Ensembl chr  X:70,268,305...70,281,840
JBrowse link
G ARRB1 arrestin beta 1 involved_in IBA
IMP
(PMID:21873635)
(PMID:10521508), (PMID:12582207)
GO_Central
UniProt
PMID:10521508 PMID:12582207 PMID:21873635 NCBI chr11:75,260,122...75,351,662
Ensembl chr11:75,260,122...75,351,705
JBrowse link
G ARRB2 arrestin beta 2 involved_in IBA
TAS
IMP
IDA
(PMID:21873635)
(PMID:24157794)
(PMID:12582207)
(PMID:10644702)
GO_Central
ParkinsonsUK-UCL
UniProt
PMID:10644702 PMID:12582207 PMID:21873635 PMID:24157794 NCBI chr17:4,710,619...4,721,500
Ensembl chr17:4,710,596...4,721,499
JBrowse link
G CALCA calcitonin related polypeptide alpha involved_in IDA (PMID:10882736) UniProt PMID:10882736 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,351
JBrowse link
G DNM1 dynamin 1 involved_in IEA
ISO
Ensembl
RGD
PMID:14709338 GO_REF:0000107 RGD:9685157 NCBI chr 9:128,203,379...128,255,244
Ensembl chr 9:128,191,655...128,255,248
JBrowse link
G DNM2 dynamin 2 involved_in IEA
ISO
Ensembl
RGD
PMID:14709338 GO_REF:0000107 RGD:9685157 NCBI chr19:10,718,079...10,831,903
Ensembl chr19:10,718,055...10,833,488
JBrowse link
G DRD2 dopamine receptor D2 involved_in IEA
ISO
Ensembl
RGD
PMID:14617818 GO_REF:0000107 RGD:1581465 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G DRD3 dopamine receptor D3 involved_in IDA
ISO
(PMID:18424554) BHF-UCL
RGD
PMID:14617818 PMID:18424554 RGD:1581465 NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 involved_in IEA
ISO
Ensembl
RGD
PMID:12519791 GO_REF:0000107 RGD:1304268 NCBI chr 4:2,963,504...3,040,760
Ensembl chr 4:2,963,571...3,040,760
JBrowse link
G GTF2H2 general transcription factor IIH subunit 2 involved_in IMP (PMID:15775968) UniProt PMID:15775968 NCBI chr 5:71,035,124...71,109,113
Ensembl chr 5:71,032,670...71,067,689
JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:77,460,924...77,463,491
Ensembl chr 6:77,460,924...77,463,491
JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:231,108,230...231,126,172
Ensembl chr 2:231,108,230...231,125,042
JBrowse link
G PLD2 phospholipase D2 acts_upstream_of_or_within ISO (MGI:3042801|PMID:14718562) MGI PMID:14718562 MGI:3042801 NCBI chr17:4,807,152...4,823,432
Ensembl chr17:4,807,152...4,823,434
JBrowse link
G SAG S-antigen visual arrestin involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:233,307,816...233,347,066
Ensembl chr 2:233,307,816...233,347,055
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chr 7:44,217,154...44,326,167
Ensembl chr 7:44,217,150...44,334,577
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 involved_in IDA (PMID:17689978) UniProt PMID:17689978 NCBI chr16:83,968,244...84,002,776
Ensembl chr16:83,968,244...84,002,776
JBrowse link
G UBQLN2 ubiquilin 2 involved_in IMP (PMID:18199683) UniProt PMID:18199683 NCBI chr  X:56,563,627...56,567,868
Ensembl chr  X:56,563,627...56,567,868
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APELA apelin receptor early endogenous ligand involved_in IMP (PMID:25639753) UniProt PMID:25639753 NCBI chr 4:164,877,023...164,899,063
Ensembl chr 4:164,877,178...164,898,965
JBrowse link
G APLN apelin involved_in IDA (PMID:11359874) UniProt PMID:11359874 NCBI chr  X:129,645,259...129,654,956
Ensembl chr  X:129,645,259...129,654,956
JBrowse link
G APP amyloid beta precursor protein involved_in IDA (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor involved_in IMP (PMID:25639753) UniProt PMID:25639753 NCBI chr11:57,233,591...57,237,250
Ensembl chr11:57,233,577...57,237,235
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,808
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,808
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18532
    cellular process 17456
      signal transduction 6271
        negative regulation of signal transduction 1342
          negative adaptation of signaling pathway 32
            desensitization of G protein-coupled receptor signaling pathway 32
              G protein-coupled receptor internalization + 21
              desensitization of G protein-coupled receptor signaling pathway by arrestin 3
              inhibitory G protein-coupled receptor phosphorylation + 3
Path 2
Term Annotations click to browse term
  biological_process 18532
    biological regulation 13076
      regulation of biological process 12362
        regulation of cellular process 11852
          signal transduction 6271
            regulation of signal transduction 3165
              negative regulation of signal transduction 1342
                negative adaptation of signaling pathway 32
                  desensitization of G protein-coupled receptor signaling pathway 32
                    G protein-coupled receptor internalization + 21
                    desensitization of G protein-coupled receptor signaling pathway by arrestin 3
                    inhibitory G protein-coupled receptor phosphorylation + 3
paths to the root