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ONTOLOGY REPORT - ANNOTATIONS

Term:desensitization of G protein-coupled receptor signaling pathway
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Accession:GO:0002029 term browser browse the term
Definition:The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
Synonyms:exact_synonym: desensitisation of G-protein coupled receptor protein signalling pathway;   desensitization of G-protein coupled receptor protein signaling pathway

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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB2 arrestin beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:4,191,040...4,202,382
Ensembl chr16:4,191,172...4,202,385 		JBrowse link
G GIPR gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chr 6:39,108,319...39,122,973
Ensembl chr 6:39,110,387...39,122,874 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:7761854)
(PMID:10338466)		 RGD
TreeGrafter
MGI
Ensembl		 PMID:7761854 PMID:10338466 PMID:17908240 PMID:30075183 GO_REF:0000107 GO_REF:0000118 RGD:13792694 RGD:7242040 NCBI chr 1:6,975,202...6,995,369
Ensembl chr 1:6,975,002...6,995,259 		JBrowse link
G GRK3 G protein-coupled receptor kinase 3 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:8381966 PMID:20837135 GO_REF:0000118 RGD:5685022 RGD:5685621 NCBI chr19:8,438,543...8,601,652
Ensembl chr19:8,438,380...8,600,359 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chr27:45,691,936...45,765,334 JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chr 9:111,996,780...112,249,247
Ensembl chr 9:111,996,599...112,244,570 		JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chr23:79,437,056...79,454,213
Ensembl chr23:79,437,078...79,453,113 		JBrowse link
G GRM5 glutamate metabotropic receptor 5 involved_in ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr 1:79,636,636...80,206,471 JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chr20:62,093,830...62,293,360
Ensembl chr20:62,095,458...62,174,959 		JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:54,518,359...54,520,683
Ensembl chr 1:54,518,358...54,520,686 		JBrowse link
G ARR3 arrestin 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:60,111,875...60,127,144
Ensembl chr  X:60,114,643...60,127,255 		JBrowse link
G ARRB1 arrestin beta 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:66,489,358...66,580,167
Ensembl chr 1:66,490,102...66,580,154 		JBrowse link
G ARRB2 arrestin beta 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:4,191,040...4,202,382
Ensembl chr16:4,191,172...4,202,385 		JBrowse link
G DNM1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chr12:9,874,098...9,927,737
Ensembl chr12:9,878,966...9,927,744 		JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chr 6:9,718,014...9,830,061
Ensembl chr 6:9,718,244...9,831,206 		JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736 		JBrowse link
G DRD3 dopamine receptor D3 involved_in ISO
IEA		 RGD
Ensembl		 PMID:14617818 GO_REF:0000107 RGD:1581465 NCBI chr22:66,683,987...66,737,645
Ensembl chr22:66,691,177...66,736,690 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:12519791 RGD:1304268 NCBI chr27:45,691,936...45,765,334 JBrowse link
G GTF2H2 general transcription factor IIH subunit 2 involved_in ISO (PMID:15775968) UniProt PMID:15775968 NCBI chr 4:65,650,735...65,682,004 JBrowse link
G LOC103239768 calcitonin involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chr 1:49,946,574...49,956,010
Ensembl chr 1:49,951,694...49,954,092 		JBrowse link
G PLD2 phospholipase D2 acts_upstream_of_or_within ISO (PMID:14718562) MGI PMID:14718562 NCBI chr16:4,283,248...4,298,034
Ensembl chr16:4,283,521...4,298,632 		JBrowse link
G SAG S-antigen visual arrestin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:119,343,562...119,383,119
Ensembl chr10:119,344,090...119,382,983 		JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (PMID:19332541) MGI PMID:19332541 NCBI chr21:14,342,751...14,451,274
Ensembl chr21:14,342,892...14,451,282 		JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:69,380,328...69,413,985 JBrowse link
G UBQLN2 ubiquilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:52,486,154...52,489,531
Ensembl chr  X:52,486,454...52,488,328 		JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APELA apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) UniProt PMID:25639753
G APLN apelin involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:104,885,639...104,896,371
Ensembl chr  X:104,888,996...104,895,014 		JBrowse link
G APLNR apelin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:16,007,092...16,011,868
Ensembl chr 1:16,008,300...16,009,601 		JBrowse link
G APP amyloid beta precursor protein involved_in ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chr 2:66,037,224...66,320,860
Ensembl chr 2:66,037,261...66,321,306 		JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr20:62,093,830...62,293,360
Ensembl chr20:62,095,458...62,174,959 		JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr20:62,093,830...62,293,360
Ensembl chr20:62,095,458...62,174,959 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19806
    cellular process 19328
      signal transduction 5636
        negative regulation of signal transduction 1468
          negative adaptation of signaling pathway 28
            desensitization of G protein-coupled receptor signaling pathway 27
              G protein-coupled receptor internalization + 20
              inhibitory G protein-coupled receptor phosphorylation + 2
Path 2
Term Annotations click to browse term
  biological_process 19806
    biological regulation 12150
      regulation of biological process 11755
        signaling 6158
          signal transduction 5636
            regulation of signal transduction 3205
              negative regulation of signal transduction 1468
                negative adaptation of signaling pathway 28
                  desensitization of G protein-coupled receptor signaling pathway 27
                    G protein-coupled receptor internalization + 20
                    inhibitory G protein-coupled receptor phosphorylation + 2
paths to the root