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ONTOLOGY REPORT - ANNOTATIONS


Term:desensitization of G protein-coupled receptor signaling pathway
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Accession:GO:0002029 term browser browse the term
Definition:The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
Synonyms:exact_synonym: desensitisation of G-protein coupled receptor protein signalling pathway;   desensitization of G-protein coupled receptor protein signaling pathway


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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GIPR gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chr19:42,673,553...42,688,059
Ensembl chr19:51,213,090...51,225,293
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 involved_in
acts_upstream_of_or_within
ISO (PMID:15102938)
(MGI:1337704|PMID:10338466)
(MGI:84440|PMID:7761854)
PMID:18223549
RGD
UniProt
MGI
BHF-UCL
PMID:7761854 PMID:10338466 PMID:15102938 PMID:17908240 PMID:18223549 PMID:30075183 MGI:1337704 MGI:84440 RGD:13792694 RGD:7242040 RGD:8553863 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066
JBrowse link
G GRK3 G protein-coupled receptor kinase 3 ISO RGD PMID:8381966 PMID:20837135 RGD:5685022 RGD:5685621 NCBI chr22:6,579,664...6,789,846
Ensembl chr22:24,353,533...24,509,560
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chr 4:3,106,064...3,181,270
Ensembl chr 4:3,008,126...3,083,094
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chr10:115,776,236...116,026,221
Ensembl chr10:119,200,688...119,450,809
JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chr 5:172,704,978...172,744,907
Ensembl chr 5:179,790,662...179,807,410
JBrowse link
G GRM5 glutamate metabotropic receptor 5 involved_in ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr11:83,514,978...84,077,650
Ensembl chr11:87,107,788...87,868,953
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chr 1:70,076,610...70,271,475
Ensembl chr 1:72,059,441...72,254,063
JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 involved_in ISO (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892
JBrowse link
G ADRB3 adrenoceptor beta 3 NOT|involved_in ISO (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chr 8:37,263,730...37,267,475 JBrowse link
G ARRB2 arrestin beta 2 involved_in ISO (PMID:12582207) RGD
UniProt
PMID:12582207 PMID:20705669 RGD:5509896 NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842
JBrowse link
G ARRB1 arrestin beta 1 involved_in ISO (PMID:10521508), (PMID:12582207) UniProt PMID:10521508 PMID:12582207 NCBI chr11:70,319,935...70,411,276
Ensembl chr11:73,630,276...73,654,155
JBrowse link
G ARRB2 arrestin beta 2 involved_in ISO (PMID:10644702)
(PMID:12582207)
UniProt PMID:10644702 PMID:12582207 NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517
JBrowse link
G CALCA calcitonin related polypeptide alpha involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chr11:15,055,897...15,061,539
Ensembl chr11:14,745,588...14,751,267
JBrowse link
G DNM1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chr 9:99,324,385...99,376,262
Ensembl chr 9:128,004,508...128,044,690
JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chr19:10,272,172...10,386,032
Ensembl chr19:10,933,672...11,106,478
JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chr11:108,289,838...108,357,174
Ensembl chr11:112,132,703...112,198,935
JBrowse link
G DRD3 dopamine receptor D3 involved_in ISO (PMID:18424554) RGD
BHF-UCL
PMID:14617818 PMID:18424554 RGD:1581465 NCBI chr 3:111,265,834...111,317,176
Ensembl chr 3:118,187,636...118,237,403
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:12519791 RGD:1304268 NCBI chr 4:3,106,064...3,181,270
Ensembl chr 4:3,008,126...3,083,094
JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B involved_in ISO (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chr 6:75,309,078...75,313,747
Ensembl chr 6:78,596,408...78,597,580
JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B involved_in ISO (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chr2B:118,362,719...118,381,253
Ensembl chr2B:237,153,709...237,170,591
JBrowse link
G PLD2 phospholipase D2 acts_upstream_of_or_within ISO (MGI:3042801|PMID:14718562) MGI PMID:14718562 MGI:3042801 NCBI chr17:4,853,919...4,870,254
Ensembl chr17:4,843,217...4,858,425
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chr 7:44,930,859...45,040,078
Ensembl chr 7:45,001,267...45,110,342
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) UniProt PMID:17689978 NCBI chr16:64,636,198...64,670,019
Ensembl chr16:83,983,626...84,013,436
JBrowse link
G UBQLN2 ubiquilin 2 involved_in ISO (PMID:18199683) UniProt PMID:18199683 NCBI chr  X:48,829,844...48,835,040
Ensembl chr  X:56,981,985...56,983,859
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APELA apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) UniProt PMID:25639753 NCBI chr 4:157,125,485...157,145,999
Ensembl chr 4:169,176,910...169,195,553
JBrowse link
G APLN apelin involved_in ISO (PMID:11359874)
(MGI:5902690|PMID:11359874)
UniProt PMID:11359874 MGI:5902690 RGD:12907555 NCBI chr  X:118,775,509...118,785,224 JBrowse link
G APP amyloid beta precursor protein involved_in ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor involved_in ISO (PMID:25639753) UniProt PMID:25639753 NCBI chr11:52,475,088...52,479,102
Ensembl chr 3:159,967,360...159,968,502
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 1:70,076,610...70,271,475
Ensembl chr 1:72,059,441...72,254,063
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 1:70,076,610...70,271,475
Ensembl chr 1:72,059,441...72,254,063
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12650
    cellular process 11785
      signal transduction 3925
        negative regulation of signal transduction 1183
          negative adaptation of signaling pathway 28
            desensitization of G protein-coupled receptor signaling pathway 28
              G protein-coupled receptor internalization + 18
              desensitization of G protein-coupled receptor signaling pathway by arrestin 3
              inhibitory G protein-coupled receptor phosphorylation + 3
Path 2
Term Annotations click to browse term
  biological_process 12650
    biological regulation 9216
      regulation of biological process 8710
        regulation of cellular process 8237
          signal transduction 3925
            regulation of signal transduction 2618
              negative regulation of signal transduction 1183
                negative adaptation of signaling pathway 28
                  desensitization of G protein-coupled receptor signaling pathway 28
                    G protein-coupled receptor internalization + 18
                    desensitization of G protein-coupled receptor signaling pathway by arrestin 3
                    inhibitory G protein-coupled receptor phosphorylation + 3
paths to the root