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ONTOLOGY REPORT - ANNOTATIONS


Term:desensitization of G protein-coupled receptor signaling pathway
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Accession:GO:0002029 term browser browse the term
Definition:The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
Synonyms:exact_synonym: desensitisation of G-protein coupled receptor protein signalling pathway;   desensitization of G-protein coupled receptor protein signaling pathway


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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gipr gastric inhibitory polypeptide receptor JBrowse link 1 80,063,047 80,073,223 RGD:2312614
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:632163
RGD:13792694
RGD:1624291
RGD:1600115
RGD:8553863
RGD:7242040
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:632163
RGD:5685621
RGD:5685022
G Grk4 G protein-coupled receptor kinase 4 JBrowse link 14 81,261,708 81,339,516 RGD:1598508
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:61618
RGD:13792694
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:1299124
RGD:7242040
G Grm5 glutamate metabotropic receptor 5 JBrowse link 1 151,207,846 151,785,038 RGD:728711
G Ly6g6e lymphocyte antigen 6 family member G6E JBrowse link 20 5,063,148 5,069,032 RGD:1624291
RGD:13792537
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:9850278
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1624291
RGD:1600115
G Adrb3 adrenoceptor beta 3 JBrowse link 16 69,003,541 69,006,632 RGD:1624291
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5509896
RGD:1624291
G protein-coupled receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:1624291
G Arr3 arrestin 3 JBrowse link X 70,438,590 70,452,140 RGD:13792537
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:1624291
RGD:13792537
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:1624291
RGD:13792537
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:1624291
G Dnm1 dynamin 1 JBrowse link 3 11,338,081 11,382,043 RGD:9685157
G Dnm2 dynamin 2 JBrowse link 8 22,458,869 22,540,649 RGD:9685157
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1581465
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:1581465
RGD:1624291
G Grk4 G protein-coupled receptor kinase 4 JBrowse link 14 81,261,708 81,339,516 RGD:1304268
G Htr1b 5-hydroxytryptamine receptor 1B JBrowse link 8 89,113,984 89,130,830 RGD:1624291
G Htr2b 5-hydroxytryptamine receptor 2B JBrowse link 9 93,112,781 93,130,135 RGD:1600115
RGD:1624291
G Pld2 phospholipase D2 JBrowse link 10 57,161,921 57,181,148 RGD:1624291
G Sag S-antigen visual arrestin JBrowse link 9 94,926,901 94,972,162 RGD:13792537
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:1624291
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Necab2 N-terminal EF-hand calcium binding protein 2 JBrowse link 19 52,086,325 52,112,633 RGD:1624291
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:1624291
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apln apelin JBrowse link X 134,856,719 134,866,210 RGD:12907555
RGD:1624291
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aplnr apelin receptor JBrowse link 3 72,540,538 72,544,183 RGD:1624291
RGD:1600115
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:10043344
prostaglandin receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:10043344

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19439
    cellular process 18178
      signal transduction 6902
        negative regulation of signal transduction 1221
          negative adaptation of signaling pathway 30
            desensitization of G protein-coupled receptor signaling pathway 30
              G protein-coupled receptor internalization + 19
              desensitization of G protein-coupled receptor signaling pathway by arrestin 3
              inhibitory G protein-coupled receptor phosphorylation + 3
Path 2
Term Annotations click to browse term
  biological_process 19439
    biological regulation 13444
      regulation of biological process 12747
        regulation of cellular process 12246
          signal transduction 6902
            regulation of signal transduction 2901
              negative regulation of signal transduction 1221
                negative adaptation of signaling pathway 30
                  desensitization of G protein-coupled receptor signaling pathway 30
                    G protein-coupled receptor internalization + 19
                    desensitization of G protein-coupled receptor signaling pathway by arrestin 3
                    inhibitory G protein-coupled receptor phosphorylation + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.