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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of the force of heart contraction
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Accession:GO:0002026 term browser browse the term
Definition:Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
Synonyms:exact_synonym: cardiac inotropy;   heart inotropy


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regulation of the force of heart contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin IDA RGD PMID:19520650 RGD:2325635 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Apln apelin IMP RGD PMID:17055480 RGD:1626171 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 acts_upstream_of_or_within ISO MGI:2451290|MGI:3527337 (MGI:1337471|PMID:10360172), (MGI:3525392|PMID:15485817) RGD PMID:10360172 PMID:15485817 MGI:1337471 MGI:3525392 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 acts_upstream_of_or_within ISO MGI:2451291 (MGI:1337471|PMID:10360172) RGD PMID:10360172 MGI:1337471 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:97622 (MGI:1347184|PMID:10555147) RGD PMID:10555147 MGI:1347184 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Cav1 caveolin 1 acts_upstream_of_or_within ISO MGI:2154537 (MGI:3612726|PMID:16380094) RGD PMID:16380094 MGI:3612726 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Chga chromogranin A IDA RGD PMID:22459152 RGD:6906968 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
G Csrp3 cysteine and glycine rich protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:97622 (MGI:1347184|PMID:10555147)		 Ensembl
RGD		 PMID:10555147 GO_REF:0000107 MGI:1347184 NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653 		JBrowse link
G Gaa alpha glucosidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2179961 (MGI:2136118|PMID:11328962)		 Ensembl
RGD		 PMID:11328962 GO_REF:0000107 MGI:2136118 NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836 		JBrowse link
G Glrx3 glutaredoxin 3 involved_in ISO (MGI:4461873|PMID:18258855) RGD PMID:18258855 MGI:4461873 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:87937 (MGI:84440|PMID:7761854)
PMID:21873635		 RGD PMID:7761854 PMID:21873635 MGI:84440, RGD:13792537 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Ifng interferon gamma IDA RGD PMID:1900518 RGD:2311499 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Myh6 myosin heavy chain 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2182704 (MGI:1202509|PMID:9541509)
(PMID:15621050)		 Ensembl
RGD		 PMID:9541509 PMID:15621050 GO_REF:0000107 MGI:1202509 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 involved_in ISO
IEA		 (PMID:15621050)
GO_REF:0000107		 RGD
Ensembl		 PMID:15621050 GO_REF:0000107 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Myl2 myosin light chain 2 involved_in IDA PMID:15331360 UniProt PMID:15331360 RGD:10400860 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983 		JBrowse link
G Myl3 myosin light chain 3 involved_in ISO (PMID:16675844) RGD PMID:16675844 NCBI chr 8:110,738,669...110,744,814
Ensembl chr 8:110,738,661...110,744,816 		JBrowse link
G Myl4 myosin, light chain 4 involved_in ISO (PMID:16675844) RGD PMID:16675844 NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363 		JBrowse link
G Pde5a phosphodiesterase 5A IMP RGD PMID:17606845 RGD:2314467 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 IDA RGD PMID:16608915 RGD:2302820 NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862 		JBrowse link
G Pln phospholamban acts_upstream_of_or_within ISO MGI:1330824|MGI:2158357|MGI:88110 (MGI:1347184|PMID:10555147), (MGI:3655341|PMID:9118481) RGD PMID:9118481 PMID:10555147 MGI:1347184 MGI:3655341 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Prkca protein kinase C, alpha acts_upstream_of_or_within ISO MGI:3037088 (MGI:3033566|PMID:14966518) RGD PMID:14966518 MGI:3033566 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 acts_upstream_of_or_within ISO MGI:3609617 (MGI:3607962|PMID:12767889) RGD PMID:12767889 MGI:3607962 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 IMP RGD PMID:21659487 RGD:6771329 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
negative regulation of the force of heart contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO (PMID:17242280) RGD PMID:17242280 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246 		JBrowse link
negative regulation of the force of heart contraction by chemical signal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grk2 G protein-coupled receptor kinase 2 involved_in ISO
IEA		 (PMID:15051637)
GO_REF:0000107		 RGD
Ensembl		 PMID:15051637 GO_REF:0000107 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
positive regulation of the force of heart contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myl2 myosin light chain 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5688843|PMID:16908724)		 UniProt
RGD		 PMID:16908724 GO_REF:0000024 MGI:5688843 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983 		JBrowse link
G Nos1 nitric oxide synthase 1 involved_in ISO (MGI:3771112|PMID:17242280) RGD PMID:17242280 MGI:3771112 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Ryr2 ryanodine receptor 2 involved_in ISO
IEA		 (PMID:15105296)
GO_REF:0000107		 RGD
Ensembl		 PMID:15105296 GO_REF:0000107 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 involved_in ISO (PMID:15105296) RGD PMID:15105296 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 involved_in ISO (PMID:15105296) RGD PMID:15105296 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
positive regulation of the force of heart contraction by epinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 IDA RGD PMID:19133992 RGD:5129126 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
positive regulation of the force of heart contraction by epinephrine-norepinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A acts_upstream_of_or_within ISO MGI:104774 (MGI:2656483|PMID:12595294) RGD PMID:12595294 MGI:2656483 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B acts_upstream_of_or_within ISO MGI:104773 (MGI:2656483|PMID:12595294) RGD PMID:12595294 MGI:2656483 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adrb1 adrenoceptor beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857120 (MGI:82113|PMID:8693001), (MGI:84440|PMID:7761854)		 Ensembl
RGD		 PMID:7761854 PMID:8693001 GO_REF:0000107 MGI:82113 MGI:84440 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
positive regulation of the force of heart contraction by norepinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IDA RGD PMID:19133992 RGD:5129126 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
regulation of the force of heart contraction by cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pln phospholamban acts_upstream_of_or_within ISO MGI:2158357 (MGI:1352349|PMID:10644605) RGD PMID:10644605 MGI:1352349 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Slc9a1 solute carrier family 9 member A1 involved_in ISO (PMID:21359875) RGD PMID:21359875 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
regulation of the force of heart contraction by chemical signal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 acts_upstream_of_or_within ISO MGI:97362 (MGI:3832129|PMID:18951881) RGD PMID:18951881 MGI:3832129 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Nos3 nitric oxide synthase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:102709 (MGI:3832129|PMID:18951881)		 Ensembl
RGD		 PMID:18951881 GO_REF:0000107 MGI:3832129 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19748
    biological regulation 13456
      regulation of biological quality 3339
        regulation of the force of heart contraction 31
          negative regulation of the force of heart contraction 1
          positive regulation of the force of heart contraction 5
          regulation of the force of heart contraction by cardiac conduction 2
          regulation of the force of heart contraction by chemical signal + 7
Path 2
Term Annotations click to browse term
  biological_process 19748
    multicellular organismal process 9185
      system process 3517
        circulatory system process 601
          blood circulation 566
            heart contraction 254
              regulation of heart contraction 209
                regulation of the force of heart contraction 31
                  negative regulation of the force of heart contraction 1
                  positive regulation of the force of heart contraction 5
                  regulation of the force of heart contraction by cardiac conduction 2
                  regulation of the force of heart contraction by chemical signal + 7
paths to the root