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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of the force of heart contraction
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Accession:GO:0002026 term browser browse the term
Definition:Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
Synonyms:exact_synonym: cardiac inotropy;   heart inotropy

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regulation of the force of heart contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin IDA RGD PMID:19520650 RGD:2325635 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259 		JBrowse link
G Apln apelin IMP RGD PMID:17055480 RGD:1626171 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO MGI:2451290|MGI:3527337 (MGI:1337471|PMID:10360172), (MGI:3525392|PMID:15485817) RGD PMID:10360172 PMID:15485817 MGI:1337471 MGI:3525392 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 ISO MGI:2451291 (MGI:1337471|PMID:10360172) RGD PMID:10360172 MGI:1337471 NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO MGI:97622 (MGI:1347184|PMID:10555147) RGD PMID:10555147 MGI:1347184 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326 		JBrowse link
G Cav1 caveolin 1 ISO MGI:2154537 (MGI:3612726|PMID:16380094) RGD PMID:16380094 MGI:3612726 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Chga chromogranin A IDA RGD PMID:22459152 RGD:6906968 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568 		JBrowse link
G Csrp3 cysteine and glycine rich protein 3 involved_in IEA
ISO		 GO_REF:0000107
MGI:97622 (MGI:1347184|PMID:10555147)		 Ensembl
RGD		 PMID:10555147 GO_REF:0000107 MGI:1347184 NCBI chr 1:104,147,205...104,166,389
Ensembl chr 1:104,147,206...104,166,367 		JBrowse link
G Gaa alpha glucosidase IEA
ISO		 GO_REF:0000107
MGI:2179961 (MGI:2136118|PMID:11328962)		 Ensembl
RGD		 PMID:11328962 GO_REF:0000107 MGI:2136118 NCBI chr10:108,395,873...108,412,999
Ensembl chr10:108,395,860...108,413,059 		JBrowse link
G Glrx3 glutaredoxin 3 ISO (MGI:4461873|PMID:18258855) RGD PMID:18258855 MGI:4461873 NCBI chr 1:209,768,696...209,799,912
Ensembl chr 1:209,768,696...209,799,903 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO MGI:87937 (MGI:84440|PMID:7761854) RGD PMID:7761854 MGI:84440 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328 		JBrowse link
G Ifng interferon gamma IDA RGD PMID:1900518 RGD:2311499 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Myh6 myosin heavy chain 6 involved_in ISO
IEA		 (PMID:15621050)
GO_REF:0000107
MGI:2182704 (MGI:1202509|PMID:9541509)		 RGD
Ensembl		 PMID:9541509 PMID:15621050 GO_REF:0000107 MGI:1202509 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699 		JBrowse link
G Myh7 myosin heavy chain 7 involved_in ISO
IEA		 (PMID:15621050)
GO_REF:0000107		 RGD
Ensembl		 PMID:15621050 GO_REF:0000107 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089 		JBrowse link
G Myl2 myosin light chain 2 involved_in IDA PMID:15331360 UniProt PMID:15331360, PMID:15331360 RGD:10400860, RGD:10400860 NCBI chr12:39,951,863...39,959,065
Ensembl chr12:39,951,987...39,958,239 		JBrowse link
G Myl3 myosin light chain 3 involved_in ISO (PMID:16675844) RGD PMID:16675844 NCBI chr 8:119,030,852...119,036,996
Ensembl chr 8:119,030,875...119,036,996 		JBrowse link
G Myl4 myosin, light chain 4 involved_in ISO
IEA		 (PMID:16675844)
GO_REF:0000107		 RGD
Ensembl		 PMID:16675844 GO_REF:0000107 NCBI chr10:92,628,356...92,638,100
Ensembl chr10:92,628,356...92,638,100 		JBrowse link
G Pde5a phosphodiesterase 5A IMP RGD PMID:17606845 RGD:2314467 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 IDA RGD PMID:16608915 RGD:2302820 NCBI chr12:45,026,948...45,031,148
Ensembl chr12:45,026,886...45,031,145 		JBrowse link
G Pln phospholamban ISO MGI:1330824|MGI:2158357|MGI:88110 (MGI:1347184|PMID:10555147), (MGI:3655341|PMID:9118481) RGD PMID:9118481 PMID:10555147 MGI:1347184 MGI:3655341 NCBI chr20:34,633,157...34,642,904
Ensembl chr20:34,633,157...34,642,904 		JBrowse link
G Prkca protein kinase C, alpha ISO MGI:3037088 (MGI:3033566|PMID:14966518) RGD PMID:14966518 MGI:3033566 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO MGI:3609617 (MGI:3607962|PMID:12767889) RGD PMID:12767889 MGI:3607962 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 IMP RGD PMID:21659487 RGD:6771329 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316 		JBrowse link
negative regulation of the force of heart contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO (PMID:17242280) RGD PMID:17242280 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823 		JBrowse link
negative regulation of the force of heart contraction by chemical signal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grk2 G protein-coupled receptor kinase 2 involved_in ISO
IEA		 (PMID:15051637)
GO_REF:0000107		 RGD
Ensembl		 PMID:15051637 GO_REF:0000107 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328 		JBrowse link
positive regulation of the force of heart contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myl2 myosin light chain 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5688843|PMID:16908724)		 UniProt
RGD		 PMID:16908724 GO_REF:0000024 MGI:5688843 NCBI chr12:39,951,863...39,959,065
Ensembl chr12:39,951,987...39,958,239 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO (MGI:3771112|PMID:17242280) RGD PMID:17242280 MGI:3771112 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341 		JBrowse link
G Ryr2 ryanodine receptor 2 involved_in ISO
IEA		 (PMID:15105296)
GO_REF:0000107		 RGD
Ensembl		 PMID:15105296 GO_REF:0000107 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 involved_in ISO (PMID:15105296) RGD PMID:15105296 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 involved_in ISO (PMID:15105296) RGD PMID:15105296 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316 		JBrowse link
positive regulation of the force of heart contraction by epinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 IDA RGD PMID:19133992 RGD:5129126 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834 		JBrowse link
positive regulation of the force of heart contraction by epinephrine-norepinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A ISO MGI:104774 (MGI:2656483|PMID:12595294) RGD PMID:12595294 MGI:2656483 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451 		JBrowse link
G Adra1b adrenoceptor alpha 1B ISO MGI:104773 (MGI:2656483|PMID:12595294) RGD PMID:12595294 MGI:2656483 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644 		JBrowse link
G Adrb1 adrenoceptor beta 1 involved_in IEA
ISO		 GO_REF:0000107
MGI:1857120 (MGI:82113|PMID:8693001), (MGI:84440|PMID:7761854)		 Ensembl
RGD		 PMID:7761854 PMID:8693001 GO_REF:0000107 MGI:82113 MGI:84440 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985 		JBrowse link
positive regulation of the force of heart contraction by norepinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IDA RGD PMID:19133992 RGD:5129126 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985 		JBrowse link
regulation of the force of heart contraction by cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pln phospholamban ISO MGI:2158357 (MGI:1352349|PMID:10644605) RGD PMID:10644605 MGI:1352349 NCBI chr20:34,633,157...34,642,904
Ensembl chr20:34,633,157...34,642,904 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 involved_in ISO (PMID:21359875) RGD PMID:21359875 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316 		JBrowse link
regulation of the force of heart contraction by chemical signal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 involved_in IEA
ISO		 GO_REF:0000107
MGI:97362 (MGI:3832129|PMID:18951881)		 Ensembl
RGD		 PMID:18951881 GO_REF:0000107 MGI:3832129 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Nos3 nitric oxide synthase 3 involved_in IEA
ISO		 GO_REF:0000107
MGI:102709 (MGI:3832129|PMID:18951881)		 Ensembl
RGD		 PMID:18951881 GO_REF:0000107 MGI:3832129 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20078
    biological regulation 13898
      regulation of biological quality 4319
        regulation of the force of heart contraction 31
          negative regulation of the force of heart contraction 1
          positive regulation of the force of heart contraction 5
          regulation of the force of heart contraction by cardiac conduction 2
          regulation of the force of heart contraction by chemical signal + 7
Path 2
Term Annotations click to browse term
  biological_process 20078
    multicellular organismal process 9072
      system process 3458
        circulatory system process 567
          blood circulation 538
            heart contraction 248
              regulation of heart contraction 201
                regulation of the force of heart contraction 31
                  negative regulation of the force of heart contraction 1
                  positive regulation of the force of heart contraction 5
                  regulation of the force of heart contraction by cardiac conduction 2
                  regulation of the force of heart contraction by chemical signal + 7
paths to the root