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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of the force of heart contraction
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Accession:GO:0002026 term browser browse the term
Definition:Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
Synonyms:exact_synonym: cardiac inotropy;   heart inotropy



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regulation of the force of heart contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin IDA RGD PMID:19520650 RGD:2325635 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Apln apelin IMP RGD PMID:17055480 RGD:1626171 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2451290|MGI:3527337 (PMID:10360172), (PMID:15485817)
Ensembl
RGD
PMID:10360172 PMID:15485817 GO_REF:0000107 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 acts_upstream_of_or_within ISO MGI:2451291 (PMID:10360172) RGD PMID:10360172 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:97622 (PMID:10555147)
Ensembl
RGD
PMID:10555147 GO_REF:0000107 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Cav1 caveolin 1 acts_upstream_of_or_within ISO MGI:2154537 (PMID:16380094) RGD PMID:16380094 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Chga chromogranin A IDA RGD PMID:22459152 RGD:6906968 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
JBrowse link
G Csrp3 cysteine and glycine rich protein 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:97622 (PMID:10555147)
Ensembl
RGD
PMID:10555147 GO_REF:0000107 NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653
JBrowse link
G Gaa alpha glucosidase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2179961 (PMID:11328962)
Ensembl
RGD
PMID:11328962 GO_REF:0000107 NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836
JBrowse link
G Glrx3 glutaredoxin 3 involved_in ISO (MGI:4461873|PMID:18258855) RGD PMID:18258855 MGI:4461873 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
GO_REF:0000033
MGI:87937 (PMID:7761854)
GO_REF:0000118
GO_Central
RGD
TreeGrafter
PMID:7761854 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Ifng interferon gamma IDA RGD PMID:1900518 RGD:2311499 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Myh6 myosin heavy chain 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2182704 (PMID:9541509)
(PMID:15621050)
Ensembl
RGD
PMID:9541509 PMID:15621050 GO_REF:0000107 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Myh7 myosin heavy chain 7 involved_in ISO
IEA
(PMID:15621050)
GO_REF:0000107
RGD
Ensembl
PMID:15621050 GO_REF:0000107 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myl2 myosin light chain 2 involved_in IDA PMID:15331360 UniProt PMID:15331360 RGD:10400860 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983
JBrowse link
G Myl3 myosin light chain 3 involved_in ISO
IEA
(PMID:16675844)
GO_REF:0000107
RGD
Ensembl
PMID:16675844 GO_REF:0000107 NCBI chr 8:110,738,669...110,744,814
Ensembl chr 8:110,738,661...110,744,816
JBrowse link
G Myl4 myosin, light chain 4 involved_in ISO (PMID:16675844) RGD PMID:16675844 NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363
JBrowse link
G Pde5a phosphodiesterase 5A IMP RGD PMID:17606845 RGD:2314467 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 IDA RGD PMID:16608915 RGD:2302820 NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
JBrowse link
G Pln phospholamban acts_upstream_of_or_within ISO MGI:1330824|MGI:2158357|MGI:88110 (PMID:10555147), (PMID:9118481) RGD PMID:9118481 PMID:10555147 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Prkca protein kinase C, alpha acts_upstream_of_or_within ISO MGI:3037088 (PMID:14966518) RGD PMID:14966518 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Slc8a1 solute carrier family 8 member A1 acts_upstream_of_or_within ISO MGI:3609617 (PMID:12767889) RGD PMID:12767889 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
JBrowse link
G Slc9a1 solute carrier family 9 member A1 IMP RGD PMID:21659487 RGD:6771329 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
JBrowse link
negative regulation of the force of heart contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO (PMID:17242280) RGD PMID:17242280 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246
JBrowse link
negative regulation of the force of heart contraction by chemical signal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grk2 G protein-coupled receptor kinase 2 involved_in ISO
IEA
(PMID:15051637)
GO_REF:0000107
RGD
Ensembl
PMID:15051637 GO_REF:0000107 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
positive regulation of the force of heart contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myl2 myosin light chain 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5688843|PMID:16908724)
UniProt
RGD
PMID:16908724 GO_REF:0000024 MGI:5688843 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983
JBrowse link
G Nos1 nitric oxide synthase 1 involved_in ISO (MGI:3771112|PMID:17242280) RGD PMID:17242280 MGI:3771112 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Ryr2 ryanodine receptor 2 involved_in ISO
IEA
(PMID:15105296)
GO_REF:0000107
RGD
Ensembl
PMID:15105296 GO_REF:0000107 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G Slc8a1 solute carrier family 8 member A1 involved_in ISO
IEA
(PMID:15105296)
GO_REF:0000107
RGD
Ensembl
PMID:15105296 GO_REF:0000107 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
JBrowse link
G Slc9a1 solute carrier family 9 member A1 involved_in ISO (PMID:15105296) RGD PMID:15105296 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
JBrowse link
positive regulation of the force of heart contraction by epinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 IDA RGD PMID:19133992 RGD:5129126 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
positive regulation of the force of heart contraction by epinephrine-norepinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:104774 (PMID:12595294)
Ensembl
RGD
PMID:12595294 GO_REF:0000107 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B acts_upstream_of_or_within ISO MGI:104773 (PMID:12595294) RGD PMID:12595294 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adrb1 adrenoceptor beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857120 (PMID:7761854), (PMID:8693001)
Ensembl
RGD
PMID:7761854 PMID:8693001 GO_REF:0000107 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
positive regulation of the force of heart contraction by norepinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IDA RGD PMID:19133992 RGD:5129126 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
regulation of the force of heart contraction by cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pln phospholamban acts_upstream_of_or_within ISO MGI:2158357 (PMID:10644605) RGD PMID:10644605 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Slc9a1 solute carrier family 9 member A1 involved_in ISO (PMID:21359875) RGD PMID:21359875 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
JBrowse link
regulation of the force of heart contraction by chemical signal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:97362 (PMID:18951881)
Ensembl
RGD
PMID:18951881 GO_REF:0000107 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Nos3 nitric oxide synthase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:102709 (PMID:18951881)
Ensembl
RGD
PMID:18951881 GO_REF:0000107 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    biological regulation 13633
      regulation of biological quality 3390
        regulation of the force of heart contraction 31
          negative regulation of the force of heart contraction 1
          positive regulation of the force of heart contraction 5
          regulation of the force of heart contraction by cardiac conduction 2
          regulation of the force of heart contraction by chemical signal + 7
Path 2
Term Annotations click to browse term
  biological_process 20292
    multicellular organismal process 8887
      system process 3536
        circulatory system process 622
          blood circulation 593
            heart contraction 260
              regulation of heart contraction 213
                regulation of the force of heart contraction 31
                  negative regulation of the force of heart contraction 1
                  positive regulation of the force of heart contraction 5
                  regulation of the force of heart contraction by cardiac conduction 2
                  regulation of the force of heart contraction by chemical signal + 7
paths to the root