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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of systemic arterial blood pressure by circulatory renin-angiotensin
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Accession:GO:0001991 term browser browse the term
Definition:The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.
Synonyms:exact_synonym: circulatory renin-angiotensin blood pressure regulation;   circulatory renin-angiotensin regulation of blood pressure
 related_synonym: circulatory renin-angiotensin control of blood pressure;   control of blood pressure by circulatory renin-angiotensin;   renin-angiotensin blood pressure control


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regulation of systemic arterial blood pressure by circulatory renin-angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen acts_upstream_of_or_within ISO (PMID:12574102)
(PMID:9466969)
(PMID:10076178), (PMID:11606482), (PMID:7989296), (PMID:9507198), (PMID:9852267)		 MGI PMID:7989296 PMID:9466969 PMID:9507198 PMID:9852267 PMID:10076178 More... NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AGTR1 angiotensin II receptor type 1 acts_upstream_of_or_within ISO (PMID:9466969) MGI PMID:9466969 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AGTR2 angiotensin II receptor type 2 involved_in ISS
IEA		 BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974 		JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 acts_upstream_of_or_within ISO (PMID:16118390) MGI PMID:16118390 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843 		JBrowse link
angiotensin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme involved_in TAS
IEA
IDA
IC		 (PMID:11432860), (PMID:1320019), (PMID:4322742), (PMID:6270633)
(PMID:1668266)		 Reactome
Ensembl
UniProt		 PMID:1320019 PMID:1668266 PMID:4322742 PMID:6270633 PMID:11432860 GO_REF:0000107 Reactome:R-HSA-2022398 Reactome:R-HSA-2022405 Reactome:R-HSA-2065355 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G ACE2 angiotensin converting enzyme 2 involved_in TAS
IC		 (PMID:10924499) Reactome
BHF-UCL		 PMID:10924499 Reactome:R-HSA-2022378 Reactome:R-HSA-2022379 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G ATP6AP2 ATPase H+ transporting accessory protein 2 involved_in IDA (PMID:12045255), (PMID:15746149) HGNC-UCL PMID:12045255 PMID:15746149 NCBI chr  X:40,580,970...40,606,848
Ensembl chr  X:40,579,372...40,606,848 		JBrowse link
G CMA1 chymase 1 involved_in TAS Reactome Reactome:R-HSA-2022383 NCBI chr14:24,505,353...24,508,265
Ensembl chr14:24,505,353...24,508,265 		JBrowse link
G CPA3 carboxypeptidase A3 involved_in TAS Reactome Reactome:R-HSA-2028294 NCBI chr 3:148,865,296...148,897,203
Ensembl chr 3:148,865,296...148,897,203 		JBrowse link
G CTSG cathepsin G involved_in TAS Reactome Reactome:R-HSA-2022411 NCBI chr14:24,573,518...24,576,250
Ensembl chr14:24,573,518...24,576,250 		JBrowse link
G CTSZ cathepsin Z involved_in TAS Reactome Reactome:R-HSA-2022381 NCBI chr20:58,995,185...59,007,254
Ensembl chr20:58,985,686...59,008,238 		JBrowse link
G ENPEP glutamyl aminopeptidase involved_in NAS (PMID:19608358) UniProt PMID:19608358 NCBI chr 4:110,476,155...110,565,285
Ensembl chr 4:110,365,733...110,565,285 		JBrowse link
G REN renin acts_upstream_of_or_within
involved_in		 ISO
IBA
TAS
IEA
IDA		 (PMID:10617578)
(PMID:12045255)		 RGD
MGI
GO_Central
Reactome
Ensembl
HGNC-UCL		 PMID:10617578 PMID:12045255 PMID:21321306 GO_REF:0000033 GO_REF:0000107 RGD:5132599 Reactome:R-HSA-2022403 Reactome:R-HSA-2022412 Reactome:R-HSA-2065357 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324 		JBrowse link
negative regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2R coagulation factor II thrombin receptor involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770 		JBrowse link
positive regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2RL1 F2R like trypsin receptor 1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315 		JBrowse link
G OR51E2 olfactory receptor family 51 subfamily E member 2 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr11:4,680,171...4,697,853
Ensembl chr11:4,680,171...4,697,854 		JBrowse link
regulation of angiotensin levels in blood term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPA3 carboxypeptidase A3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15173164) Ensembl
MGI		 PMID:15173164 GO_REF:0000107 NCBI chr 3:148,865,296...148,897,203
Ensembl chr 3:148,865,296...148,897,203 		JBrowse link
G KCNN4 potassium calcium-activated channel subfamily N member 4 ISO RGD PMID:25715999 RGD:401794570 NCBI chr19:43,766,533...43,780,973
Ensembl chr19:43,766,533...43,780,976 		JBrowse link
G NDST2 N-deacetylase and N-sulfotransferase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15173164) Ensembl
MGI		 PMID:15173164 GO_REF:0000107 NCBI chr10:73,801,916...73,811,820
Ensembl chr10:73,801,911...73,811,798 		JBrowse link
regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 acts_upstream_of_or_within ISO (PMID:17255527) MGI PMID:17255527 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
G KCNN4 potassium calcium-activated channel subfamily N member 4 ISO RGD PMID:25715999 RGD:401794570 NCBI chr19:43,766,533...43,780,973
Ensembl chr19:43,766,533...43,780,976 		JBrowse link
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen acts_upstream_of_or_within ISO (PMID:11606482) MGI PMID:11606482 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 acts_upstream_of_or_within ISO (PMID:12167595) MGI PMID:12167595 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G COMT catechol-O-methyltransferase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19139376) Ensembl
MGI		 PMID:19139376 GO_REF:0000107 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975 		JBrowse link
G EDNRB endothelin receptor type B involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529 		JBrowse link
G PCSK5 proprotein convertase subtilisin/kexin type 5 involved_in IEP (PMID:8901832) BHF-UCL PMID:8901832 NCBI chr 9:75,889,809...76,362,975
Ensembl chr 9:75,890,644...76,362,975 		JBrowse link
G SUCNR1 succinate receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18535668) Ensembl
MGI		 PMID:18535668 GO_REF:0000107 NCBI chr 3:151,873,643...151,884,619
Ensembl chr 3:151,873,643...151,884,619 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    multicellular organismal process 8456
      system process 2748
        endocrine process 122
          regulation of systemic arterial blood pressure by hormone 47
            regulation of systemic arterial blood pressure by renin-angiotensin 33
              regulation of systemic arterial blood pressure by circulatory renin-angiotensin 23
                regulation of angiotensin levels in blood + 11
                renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure + 11
Path 2
Term Annotations click to browse term
  biological_process 19669
    multicellular organismal process 8456
      system process 2748
        circulatory system process 735
          blood circulation 651
            regulation of blood pressure 241
              regulation of systemic arterial blood pressure 127
                regulation of systemic arterial blood pressure mediated by a chemical signal 57
                  regulation of systemic arterial blood pressure by hormone 47
                    regulation of systemic arterial blood pressure by renin-angiotensin 33
                      regulation of systemic arterial blood pressure by circulatory renin-angiotensin 23
                        regulation of angiotensin levels in blood + 11
                        renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure + 11
paths to the root