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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of systemic arterial blood pressure by circulatory renin-angiotensin
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Accession:GO:0001991 term browser browse the term
Definition:The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.
Synonyms:exact_synonym: circulatory renin-angiotensin blood pressure regulation;   circulatory renin-angiotensin regulation of blood pressure
 related_synonym: circulatory renin-angiotensin control of blood pressure;   control of blood pressure by circulatory renin-angiotensin;   renin-angiotensin blood pressure control


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regulation of systemic arterial blood pressure by circulatory renin-angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within ISO MGI:1857121|MGI:2136636|MGI:2183545 (PMID:10076178), (PMID:11606482), (PMID:12574102), (PMID:7989296), (PMID:9466969), (PMID:9507198), (PMID:9852267) RGD PMID:7989296 PMID:9466969 PMID:9507198 PMID:9852267 PMID:10076178 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a acts_upstream_of_or_within ISO MGI:87965 (PMID:9466969) RGD PMID:9466969 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b acts_upstream_of_or_within ISO MGI:87964 (PMID:9466969) RGD PMID:9466969 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 involved_in ISO (MGI:76991|PMID:7477267)
(PMID:7477267)		 RGD PMID:7477267 MGI:76991 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 acts_upstream_of_or_within ISO MGI:3582593 (PMID:16118390) RGD PMID:16118390 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
angiotensin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:11432860), (PMID:1320019), (PMID:4322742), (PMID:6270633)
(MGI:3040566|PMID:14757757), (MGI:3793932|PMID:11303049)
(PMID:11303049), (PMID:14757757)		 UniProt
Ensembl
RGD		 PMID:1320019 PMID:4322742 PMID:6270633 PMID:11303049 PMID:11432860 More... GO_REF:0000024 GO_REF:0000107 MGI:3040566 MGI:3793932 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in ISO
IEA		 (PMID:12045255), (PMID:15746149)
GO_REF:0000107		 RGD
Ensembl		 PMID:12045255 PMID:15746149 GO_REF:0000107 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918 		JBrowse link
G Ren renin acts_upstream_of_or_within
involved_in		 IDA
ISO
IBA		 MGI:2136642 (PMID:10617578)
GO_REF:0000033
(PMID:12045255)		 RGD
GO_Central		 PMID:10617578 PMID:12045255 PMID:21321306 GO_REF:0000033, RGD:5132599 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
negative regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2r coagulation factor II (thrombin) receptor involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(MGI:5315674|PMID:21859963)
(PMID:21859963)		 Ensembl
UniProt
RGD		 PMID:21859963 GO_REF:0000024 GO_REF:0000107 MGI:5315674 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
positive regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5315674|PMID:21859963)		 UniProt
RGD		 PMID:21859963 GO_REF:0000024 MGI:5315674 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Olr59 olfactory receptor 59 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5574287|PMID:23401498)		 UniProt
Ensembl
RGD		 PMID:23401498 GO_REF:0000024 GO_REF:0000107 MGI:5574287 NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:157,193,080...157,211,179 		JBrowse link
regulation of angiotensin levels in blood term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpa3 carboxypeptidase A3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:96940 (PMID:15173164)		 Ensembl
RGD		 PMID:15173164 GO_REF:0000107 NCBI chr 2:102,712,483...102,744,219
Ensembl chr 2:102,712,589...102,744,203 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 IMP RGD PMID:25715999 RGD:401794570 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 acts_upstream_of_or_within ISO (PMID:15173164) RGD PMID:15173164 NCBI chr15:3,563,515...3,573,801
Ensembl chr15:3,563,358...3,573,801 		JBrowse link
regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 acts_upstream_of_or_within ISO MGI:2445238 (PMID:17255527) RGD PMID:17255527 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 IMP RGD PMID:25715999 RGD:401794570 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within ISO (PMID:11606482) RGD PMID:11606482 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS RGD PMID:10484527 RGD:1357917 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a acts_upstream_of_or_within ISO MGI:1857147 (PMID:12167595) RGD PMID:12167595 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Comt catechol-O-methyltransferase acts_upstream_of_or_within ISO MGI:2178542 (PMID:19139376) RGD PMID:19139376 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Ednrb endothelin receptor type B involved_in ISO MGI:3693642 (PMID:16868309) RGD PMID:16868309 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 involved_in ISO (PMID:8901832) RGD PMID:8901832 NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600 		JBrowse link
G Sucnr1 succinate receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3528754 (PMID:18535668)		 Ensembl
RGD		 PMID:18535668 GO_REF:0000107 NCBI chr 2:144,219,066...144,230,568
Ensembl chr 2:144,219,122...144,230,034 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20134
    multicellular organismal process 8877
      system process 3535
        endocrine process 121
          regulation of systemic arterial blood pressure by hormone 46
            regulation of systemic arterial blood pressure by renin-angiotensin 32
              regulation of systemic arterial blood pressure by circulatory renin-angiotensin 19
                regulation of angiotensin levels in blood + 6
                renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure + 12
Path 2
Term Annotations click to browse term
  biological_process 20134
    multicellular organismal process 8877
      system process 3535
        circulatory system process 614
          blood circulation 584
            regulation of blood pressure 230
              regulation of systemic arterial blood pressure 128
                regulation of systemic arterial blood pressure mediated by a chemical signal 56
                  regulation of systemic arterial blood pressure by hormone 46
                    regulation of systemic arterial blood pressure by renin-angiotensin 32
                      regulation of systemic arterial blood pressure by circulatory renin-angiotensin 19
                        regulation of angiotensin levels in blood + 6
                        renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure + 12
paths to the root