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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, dopaminergic
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Accession:GO:0001963 term browser browse the term
Definition:The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


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synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora2a adenosine A2a receptor JBrowse link 20 14,265,251 14,282,873 RGD:1624291
G Cdk5 cyclin-dependent kinase 5 JBrowse link 4 7,282,945 7,287,427 RGD:1624291
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:8553912
RGD:1624291
G Crhbp corticotropin releasing hormone binding protein JBrowse link 2 25,141,471 25,153,334 RGD:8553722
RGD:1600115
RGD:1624291
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:1600981
RGD:1600115
RGD:1624291
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1625068
RGD:13792537
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:1625068
RGD:13792537
G Drd4 dopamine receptor D4 JBrowse link 1 214,278,296 214,282,818 RGD:1600954
RGD:1600115
G Drd5 dopamine receptor D5 JBrowse link 14 77,220,579 77,222,006 RGD:1600981
RGD:1600115
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Rasd2 RASD family, member 2 JBrowse link 19 14,653,198 14,663,914 RGD:1624291
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:1624291
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:1624291
dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Slc6a2 solute carrier family 6 member 2 JBrowse link 19 15,391,682 15,431,274 RGD:13792537
G Slc6a3 solute carrier family 6 member 3 JBrowse link 1 32,323,011 32,363,983 RGD:13792537
negative regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:1624291
negative regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kcnq4 potassium voltage-gated channel subfamily Q member 4 JBrowse link 5 139,625,783 139,677,300 RGD:1600308
RGD:13792537
G Pmch pro-melanin-concentrating hormone JBrowse link 7 28,655,206 28,656,522 RGD:1642493
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:2300272
G Slc6a4 solute carrier family 6 member 4 JBrowse link 10 63,153,656 63,188,377 RGD:4889470
positive regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1624291
G Nat8l N-acetyltransferase 8-like JBrowse link 14 82,041,616 82,048,251 RGD:1624291
G Rab3b RAB3B, member RAS oncogene family JBrowse link 5 128,501,789 128,568,170 RGD:1624291
positive regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:1624291
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 2 189,088,570 189,096,785 RGD:1624291
G Flot1 flotillin 1 JBrowse link 20 3,427,890 3,438,418 RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1624291
G Gdnf glial cell derived neurotrophic factor JBrowse link 2 56,884,181 56,912,964 RGD:1600115
RGD:1624291
G Tor1a torsin family 1, member A JBrowse link 3 9,800,322 9,807,318 RGD:1624291
RGD:1600115
regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:1624291
RGD:1600115
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 2 189,088,570 189,096,785 RGD:1624291
G Cntnap4 contactin associated protein family member 4 JBrowse link 19 44,817,727 45,118,133 RGD:1624291
G Pnkd PNKD metallo-beta-lactamase domain containing JBrowse link 9 81,566,074 81,634,531 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    signaling 7553
      cell-cell signaling 1794
        synaptic signaling 913
          trans-synaptic signaling 885
            anterograde trans-synaptic signaling 876
              chemical synaptic transmission 876
                synaptic transmission, dopaminergic 31
                  dopamine secretion, neurotransmission 0
                  dopamine uptake involved in synaptic transmission + 10
                  negative regulation of synaptic transmission, dopaminergic + 5
                  positive regulation of synaptic transmission, dopaminergic + 7
                  regulation of synaptic transmission, dopaminergic + 17
Path 2
Term Annotations click to browse term
  biological_process 19858
    cellular process 18618
      cell communication 7631
        cell-cell signaling 1794
          synaptic signaling 913
            trans-synaptic signaling 885
              anterograde trans-synaptic signaling 876
                chemical synaptic transmission 876
                  synaptic transmission, dopaminergic 31
                    dopamine secretion, neurotransmission 0
                    dopamine uptake involved in synaptic transmission + 10
                    negative regulation of synaptic transmission, dopaminergic + 5
                    positive regulation of synaptic transmission, dopaminergic + 7
                    regulation of synaptic transmission, dopaminergic + 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.