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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, dopaminergic
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Accession:GO:0001963 term browser browse the term
Definition:The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


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synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADORA2A adenosine A2a receptor JBrowse link 14 49,467,186 49,485,845 RGD:14298760
G CDK5 cyclin dependent kinase 5 JBrowse link 18 6,166,914 6,171,157 RGD:14298760
G CRH corticotropin releasing hormone JBrowse link 4 68,481,696 68,486,122 RGD:14298760
G CRHBP corticotropin releasing hormone binding protein JBrowse link 2 85,814,399 85,830,598 RGD:14298760
G DRD1 dopamine receptor D1 JBrowse link 16 49,189,555 49,193,722 RGD:14298760
G DRD2 dopamine receptor D2 JBrowse link 9 41,068,618 41,135,262 RGD:14298760
G DRD3 dopamine receptor D3 JBrowse link 13 145,769,294 145,817,997 RGD:14298760
G DRD4 dopamine receptor D4 JBrowse link 2 398,766 401,539 RGD:14298760
G DRD5 dopamine receptor D5 JBrowse link 8 6,180,221 6,182,575 RGD:14298760
G PARK7 Parkinsonism associated deglycase JBrowse link 6 68,629,327 68,645,147 RGD:9068941
G PRKN parkin RBR E3 ubiquitin protein ligase JBrowse link 1 5,698,508 6,731,132 RGD:9068941
G RASD2 RASD family member 2 RGD:14298760
G SNCA synuclein alpha JBrowse link 8 129,247,724 129,388,307 RGD:14298760
G TH tyrosine hydroxylase JBrowse link 2 1,499,628 1,506,180 RGD:14298760
dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PARK7 Parkinsonism associated deglycase JBrowse link 6 68,629,327 68,645,147 RGD:14298760
G PRKN parkin RBR E3 ubiquitin protein ligase JBrowse link 1 5,698,508 6,731,132 RGD:14298760
G SLC6A2 solute carrier family 6 member 2 JBrowse link 6 29,931,650 29,981,636 RGD:14298760
G SLC6A3 solute carrier family 6 member 3 JBrowse link 16 79,186,114 79,220,302 RGD:14298760
negative regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SNCA synuclein alpha JBrowse link 8 129,247,724 129,388,307 RGD:14298760
negative regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G KCNQ4 potassium voltage-gated channel subfamily Q member 4 JBrowse link 6 170,346,135 170,401,534 RGD:9068941
G PMCH pro-melanin concentrating hormone JBrowse link 5 82,018,915 82,020,267 RGD:9068941
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 9 127,850,164 127,858,866 RGD:9068941
G SLC6A4 solute carrier family 6 member 4 JBrowse link 12 46,285,995 46,328,377 RGD:9068941
positive regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DRD2 dopamine receptor D2 JBrowse link 9 41,068,618 41,135,262 RGD:14298760
G NAT8L N-acetyltransferase 8 like JBrowse link 8 1,063,917 1,072,191 RGD:9068941
G RAB3B RAB3B, member RAS oncogene family JBrowse link 6 160,194,488 160,255,635 RGD:14298760
positive regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ARRB2 arrestin beta 2 JBrowse link 12 52,161,776 52,170,362 RGD:9068941
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 4 95,196,992 95,211,084 RGD:14298760
G FLOT1 flotillin 1 JBrowse link 7 23,253,157 23,265,165 RGD:14298760
G PINK1 PTEN induced kinase 1 JBrowse link 6 78,863,195 78,884,663 RGD:14298760
regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DRD2 dopamine receptor D2 JBrowse link 9 41,068,618 41,135,262 RGD:9068941
G GDNF glial cell derived neurotrophic factor JBrowse link 16 22,936,602 22,965,929 RGD:14298760
G TOR1A torsin family 1 member A JBrowse link 1 269,975,919 269,985,478 RGD:14298760
regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 142,803,697 142,937,124 RGD:9068941
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 4 95,196,992 95,211,084 RGD:9068941
G CNTNAP4 contactin associated protein family member 4 JBrowse link 6 11,316,534 11,589,628 RGD:14298760
G PNKD PNKD metallo-beta-lactamase domain containing JBrowse link 15 120,345,541 120,411,648 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16412
    signaling 6413
      cell-cell signaling 1680
        synaptic signaling 843
          trans-synaptic signaling 815
            anterograde trans-synaptic signaling 807
              chemical synaptic transmission 807
                synaptic transmission, dopaminergic 31
                  dopamine secretion, neurotransmission 0
                  dopamine uptake involved in synaptic transmission + 10
                  negative regulation of synaptic transmission, dopaminergic + 5
                  positive regulation of synaptic transmission, dopaminergic + 7
                  regulation of synaptic transmission, dopaminergic + 17
Path 2
Term Annotations click to browse term
  biological_process 16412
    cellular process 15625
      cell communication 6484
        cell-cell signaling 1680
          synaptic signaling 843
            trans-synaptic signaling 815
              anterograde trans-synaptic signaling 807
                chemical synaptic transmission 807
                  synaptic transmission, dopaminergic 31
                    dopamine secretion, neurotransmission 0
                    dopamine uptake involved in synaptic transmission + 10
                    negative regulation of synaptic transmission, dopaminergic + 5
                    positive regulation of synaptic transmission, dopaminergic + 7
                    regulation of synaptic transmission, dopaminergic + 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.