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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, dopaminergic
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Accession:GO:0001963 term browser browse the term
Definition:The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


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synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora2a adenosine A2a receptor JBrowse link 10 75,316,877 75,334,792 RGD:2290270
G Cdk5 cyclin-dependent kinase 5 JBrowse link 5 24,407,597 24,423,587 RGD:2290270
G Crh corticotropin releasing hormone JBrowse link 3 19,693,401 19,695,396 RGD:2290270
G Crhbp corticotropin releasing hormone binding protein JBrowse link 13 95,431,376 95,444,831 RGD:2290270
G Drd1 dopamine receptor D1 JBrowse link 13 54,051,183 54,055,658 RGD:2290270
G Drd2 dopamine receptor D2 JBrowse link 9 49,340,360 49,408,177 RGD:2290270
G Drd3 dopamine receptor D3 JBrowse link 16 43,754,015 43,825,982 RGD:2290270
G Drd4 dopamine receptor D4 JBrowse link 7 141,291,974 141,296,464 RGD:2290270
G Drd5 dopamine receptor D5 JBrowse link 5 38,319,509 38,322,523 RGD:2290270
G Park7 Parkinson disease (autosomal recessive, early onset) 7 JBrowse link 4 150,897,133 150,909,921 RGD:2290270
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 17 10,840,359 12,063,370 RGD:2290270
G Rasd2 RASD family, member 2 JBrowse link 8 75,213,944 75,224,113 RGD:2290270
G Snca synuclein, alpha JBrowse link 6 60,731,573 60,829,855 RGD:2290270
G Th tyrosine hydroxylase JBrowse link 7 142,892,779 142,899,995 RGD:2290270
dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Park7 Parkinson disease (autosomal recessive, early onset) 7 JBrowse link 4 150,897,133 150,909,921 RGD:2290270
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 17 10,840,359 12,063,370 RGD:2290270
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 JBrowse link 8 92,960,470 93,001,667 RGD:2290270
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 JBrowse link 13 73,536,128 73,578,672 RGD:2290270
negative regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Snca synuclein, alpha JBrowse link 6 60,731,573 60,829,855 RGD:2290270
negative regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kcnq4 potassium voltage-gated channel, subfamily Q, member 4 JBrowse link 4 120,696,134 120,747,491 RGD:2290270
G Pmch pro-melanin-concentrating hormone JBrowse link 10 88,091,072 88,092,374 RGD:2290270
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:2290270
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 JBrowse link 11 76,998,597 77,032,343 RGD:2290270
positive regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Drd2 dopamine receptor D2 JBrowse link 9 49,340,360 49,408,177 RGD:2290270
G Nat8l N-acetyltransferase 8-like JBrowse link 5 33,995,984 34,005,916 RGD:2290270
G Rab3b RAB3B, member RAS oncogene family JBrowse link 4 108,879,070 108,943,324 RGD:2290270
positive regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb2 arrestin, beta 2 JBrowse link 11 70,432,485 70,440,828 RGD:2290270
G Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) JBrowse link 3 89,753,448 89,764,632 RGD:2290270
G Flot1 flotillin 1 JBrowse link 17 35,823,320 35,832,789 RGD:2290270
G Pink1 PTEN induced putative kinase 1 JBrowse link 4 138,313,409 138,326,296 RGD:2290270
regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Drd2 dopamine receptor D2 JBrowse link 9 49,340,360 49,408,177 RGD:2290270
G Gdnf glial cell line derived neurotrophic factor JBrowse link 15 7,810,048 7,837,580 RGD:2290270
G Tor1a torsin family 1, member A (torsin A) JBrowse link 2 30,960,561 30,967,918 RGD:2290270
regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 JBrowse link 7 63,098,692 63,212,526 RGD:2290270
G Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) JBrowse link 3 89,753,448 89,764,632 RGD:2290270
G Cntnap4 contactin associated protein-like 4 JBrowse link 8 112,569,798 112,882,707 RGD:2290270
G Pnkd paroxysmal nonkinesiogenic dyskinesia JBrowse link 1 74,284,599 74,353,692 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23163
    signaling 6906
      cell-cell signaling 1817
        synaptic signaling 929
          trans-synaptic signaling 898
            anterograde trans-synaptic signaling 889
              chemical synaptic transmission 889
                synaptic transmission, dopaminergic 31
                  dopamine secretion, neurotransmission 0
                  dopamine uptake involved in synaptic transmission + 10
                  negative regulation of synaptic transmission, dopaminergic + 5
                  positive regulation of synaptic transmission, dopaminergic + 7
                  regulation of synaptic transmission, dopaminergic + 17
Path 2
Term Annotations click to browse term
  biological_process 23163
    cellular process 17053
      cell communication 6983
        cell-cell signaling 1817
          synaptic signaling 929
            trans-synaptic signaling 898
              anterograde trans-synaptic signaling 889
                chemical synaptic transmission 889
                  synaptic transmission, dopaminergic 31
                    dopamine secretion, neurotransmission 0
                    dopamine uptake involved in synaptic transmission + 10
                    negative regulation of synaptic transmission, dopaminergic + 5
                    positive regulation of synaptic transmission, dopaminergic + 7
                    regulation of synaptic transmission, dopaminergic + 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.