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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, dopaminergic
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Accession:GO:0001963 term browser browse the term
Definition:The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


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synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADORA2A adenosine A2a receptor JBrowse link 22 24,423,597 24,442,360 RGD:2290271
G CDK5 cyclin dependent kinase 5 JBrowse link 7 151,053,815 151,057,897 RGD:2290271
G CRH corticotropin releasing hormone JBrowse link 8 66,176,376 66,178,464 RGD:2290271
G CRHBP corticotropin releasing hormone binding protein JBrowse link 5 76,952,855 76,981,143 RGD:2290271
G DRD1 dopamine receptor D1 JBrowse link 5 175,440,036 175,444,182 RGD:2290271
G DRD2 dopamine receptor D2 JBrowse link 11 113,409,595 113,475,398 RGD:2290271
G DRD3 dopamine receptor D3 JBrowse link 3 114,127,580 114,199,407 RGD:2290271
G DRD4 dopamine receptor D4 JBrowse link 11 637,269 640,706 RGD:2290271
G DRD5 dopamine receptor D5 JBrowse link 4 9,781,634 9,784,009 RGD:2290271
G PARK7 Parkinsonism associated deglycase JBrowse link 1 7,961,654 7,985,505 RGD:9068941
G PRKN parkin RBR E3 ubiquitin protein ligase JBrowse link 6 161,347,417 162,727,802 RGD:9068941
G RASD2 RASD family member 2 JBrowse link 22 35,532,806 35,554,003 RGD:2290271
G SNCA synuclein alpha JBrowse link 4 89,724,099 89,838,324 RGD:9068941
G TH tyrosine hydroxylase JBrowse link 11 2,163,929 2,174,081 RGD:2290271
dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PARK7 Parkinsonism associated deglycase JBrowse link 1 7,961,654 7,985,505 RGD:2290271
G PRKN parkin RBR E3 ubiquitin protein ligase JBrowse link 6 161,347,417 162,727,802 RGD:2290271
G SLC6A2 solute carrier family 6 member 2 JBrowse link 16 55,655,928 55,706,192 RGD:2290271
G SLC6A3 solute carrier family 6 member 3 JBrowse link 5 1,392,794 1,445,440 RGD:2290271
G SNCA synuclein alpha JBrowse link 4 89,724,099 89,838,324 RGD:2290271
negative regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SNCA synuclein alpha JBrowse link 4 89,724,099 89,838,324 RGD:2290271
negative regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G KCNQ4 potassium voltage-gated channel subfamily Q member 4 JBrowse link 1 40,783,787 40,840,457 RGD:9068941
G PMCH pro-melanin concentrating hormone JBrowse link 12 102,196,459 102,199,540 RGD:9068941
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 186,671,791 186,680,423 RGD:2290271
G SLC6A4 solute carrier family 6 member 4 JBrowse link 17 30,194,319 30,235,697 RGD:2290271
positive regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DRD2 dopamine receptor D2 JBrowse link 11 113,409,595 113,475,398 RGD:2290271
G DRD4 dopamine receptor D4 JBrowse link 11 637,269 640,706 RGD:2290271
G NAT8L N-acetyltransferase 8 like JBrowse link 4 2,059,327 2,069,089 RGD:9068941
G RAB3B RAB3B, member RAS oncogene family JBrowse link 1 51,907,956 51,990,700 RGD:2290271
positive regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ARRB2 arrestin beta 2 JBrowse link 17 4,710,619 4,721,500 RGD:2290271
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 1 154,567,778 154,584,708 RGD:2290271
G FLOT1 flotillin 1 JBrowse link 6 30,727,709 30,742,851 RGD:2290271
G PINK1 PTEN induced kinase 1 JBrowse link 1 20,633,458 20,651,511 RGD:2290271
regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DRD1 dopamine receptor D1 JBrowse link 5 175,440,036 175,444,182 RGD:2290271
G DRD2 dopamine receptor D2 JBrowse link 11 113,409,595 113,475,398 RGD:2290271
G DRD3 dopamine receptor D3 JBrowse link 3 114,127,580 114,199,407 RGD:2290271
G GDNF glial cell derived neurotrophic factor JBrowse link 5 37,812,677 37,840,044 RGD:2290271
G TOR1A torsin family 1 member A JBrowse link 9 129,812,942 129,824,136 RGD:2290271
regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 15 32,030,462 32,173,018 RGD:9068941
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 1 154,567,778 154,584,708 RGD:2290271
G CNTNAP4 contactin associated protein family member 4 JBrowse link 16 76,277,376 76,563,610 RGD:2290271
G PNKD PNKD metallo-beta-lactamase domain containing JBrowse link 2 218,270,485 218,346,793 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18539
    signaling 7162
      cell-cell signaling 2134
        synaptic signaling 989
          trans-synaptic signaling 961
            anterograde trans-synaptic signaling 952
              chemical synaptic transmission 952
                synaptic transmission, dopaminergic 31
                  dopamine secretion, neurotransmission 0
                  dopamine uptake involved in synaptic transmission + 13
                  negative regulation of synaptic transmission, dopaminergic + 5
                  positive regulation of synaptic transmission, dopaminergic + 8
                  regulation of synaptic transmission, dopaminergic + 20
Path 2
Term Annotations click to browse term
  biological_process 18539
    cellular process 17550
      cell communication 7198
        cell-cell signaling 2134
          synaptic signaling 989
            trans-synaptic signaling 961
              anterograde trans-synaptic signaling 952
                chemical synaptic transmission 952
                  synaptic transmission, dopaminergic 31
                    dopamine secretion, neurotransmission 0
                    dopamine uptake involved in synaptic transmission + 13
                    negative regulation of synaptic transmission, dopaminergic + 5
                    positive regulation of synaptic transmission, dopaminergic + 8
                    regulation of synaptic transmission, dopaminergic + 20
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.