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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, dopaminergic
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Accession:GO:0001963 term browser browse the term
Definition:The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


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synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADORA2A adenosine A2a receptor JBrowse link 26 28,141,076 28,150,600 RGD:13508589
G CDK5 cyclin dependent kinase 5 JBrowse link 16 15,105,177 15,113,085 RGD:9068941
G CRH corticotropin releasing hormone JBrowse link 29 15,831,944 15,840,560 RGD:13508589
G CRHBP corticotropin releasing hormone binding protein JBrowse link 3 29,726,316 29,737,748 RGD:13508589
G DRD1 dopamine receptor D1 JBrowse link 4 37,550,454 37,554,641 RGD:9068941
G DRD2 dopamine receptor D2 JBrowse link 5 19,732,842 19,795,241 RGD:13508589
G DRD3 dopamine receptor D3 JBrowse link 33 18,369,362 18,414,465 RGD:13508589
G DRD5 dopamine receptor D5 JBrowse link 3 69,621,187 69,623,522 RGD:13508589
G PARK7 Parkinsonism associated deglycase JBrowse link 5 61,576,219 61,592,325 RGD:9068941
G PRKN parkin RBR E3 ubiquitin protein ligase JBrowse link 1 49,886,887 51,201,930 RGD:9068941
G RASD2 RASD family member 2 JBrowse link 10 28,626,761 28,637,861 RGD:13508589
G SNCA synuclein alpha JBrowse link 32 12,915,871 13,079,338 RGD:9068941
G TH tyrosine hydroxylase JBrowse link 18 46,327,136 46,334,973 RGD:13508589
dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PARK7 Parkinsonism associated deglycase JBrowse link 5 61,576,219 61,592,325 RGD:9068941
G PRKN parkin RBR E3 ubiquitin protein ligase JBrowse link 1 49,886,887 51,201,930 RGD:9068941
G SLC6A2 solute carrier family 6 member 2 JBrowse link 2 60,319,304 60,362,532 RGD:13508589
G SLC6A3 solute carrier family 6 member 3 JBrowse link 34 11,209,118 11,245,456 RGD:13508589
negative regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SNCA synuclein alpha JBrowse link 32 12,915,871 13,079,338 RGD:9068941
negative regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G KCNQ4 potassium voltage-gated channel subfamily Q member 4 JBrowse link 15 2,203,938 2,257,152 RGD:9068941
G PMCH pro-melanin concentrating hormone JBrowse link 15 41,036,428 41,037,571 RGD:9068941
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 7 19,668,079 19,674,903 RGD:9068941
G SLC6A4 solute carrier family 6 member 4 JBrowse link 9 44,224,026 44,259,655 RGD:9068941
positive regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DRD2 dopamine receptor D2 JBrowse link 5 19,732,842 19,795,241 RGD:13508589
G NAT8L N-acetyltransferase 8 like JBrowse link 3 62,107,060 62,113,807 RGD:9068941
G RAB3B RAB3B, member RAS oncogene family JBrowse link 15 9,305,495 9,378,003 RGD:13508589
positive regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ARRB2 arrestin beta 2 JBrowse link 5 31,831,208 31,838,875 RGD:9068941
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 7 42,786,505 42,797,976 RGD:13508589
G FLOT1 flotillin 1 JBrowse link 12 517,941 528,677 RGD:13508589
G PINK1 PTEN induced kinase 1 JBrowse link 2 78,276,091 78,293,761 RGD:9068941
regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DRD2 dopamine receptor D2 JBrowse link 5 19,732,842 19,795,241 RGD:9068941
G GDNF glial cell derived neurotrophic factor JBrowse link 4 70,966,694 70,991,860 RGD:13508589
G TOR1A torsin family 1 member A JBrowse link 9 54,017,895 54,027,049 RGD:13508589
regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 3 36,852,082 37,164,930 RGD:9068941
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 7 42,786,505 42,797,976 RGD:9068941
G CNTNAP4 contactin associated protein family member 4 JBrowse link 5 74,507,728 74,748,798 RGD:13508589
G PNKD PNKD metallo-beta-lactamase domain containing JBrowse link 37 24,948,763 25,008,542 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16042
    signaling 5937
      cell-cell signaling 1673
        synaptic signaling 851
          trans-synaptic signaling 827
            anterograde trans-synaptic signaling 818
              chemical synaptic transmission 818
                synaptic transmission, dopaminergic 30
                  dopamine secretion, neurotransmission 0
                  dopamine uptake involved in synaptic transmission + 10
                  negative regulation of synaptic transmission, dopaminergic + 5
                  positive regulation of synaptic transmission, dopaminergic + 7
                  regulation of synaptic transmission, dopaminergic + 17
Path 2
Term Annotations click to browse term
  biological_process 16042
    cellular process 15297
      cell communication 6008
        cell-cell signaling 1673
          synaptic signaling 851
            trans-synaptic signaling 827
              anterograde trans-synaptic signaling 818
                chemical synaptic transmission 818
                  synaptic transmission, dopaminergic 30
                    dopamine secretion, neurotransmission 0
                    dopamine uptake involved in synaptic transmission + 10
                    negative regulation of synaptic transmission, dopaminergic + 5
                    positive regulation of synaptic transmission, dopaminergic + 7
                    regulation of synaptic transmission, dopaminergic + 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.