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ONTOLOGY REPORT - ANNOTATIONS

Term:synaptic transmission, dopaminergic
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Accession:GO:0001963 term browser browse the term
Definition:The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


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synaptic transmission, dopaminergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor acts_upstream_of_or_within ISO MGI:98735 (MGI:2450064|PMID:12538862) RGD PMID:12538862 MGI:2450064 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit acts_upstream_of_or_within ISO MGI:1915568 (MGI:3804503|PMID:18626010) RGD PMID:18626010 MGI:3804503 NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3033267|PMID:14769920)
GO_REF:0000107		 RGD
Ensembl		 PMID:14769920 GO_REF:0000107 MGI:3033267 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Comt catechol-O-methyltransferase acts_upstream_of_or_within ISO MGI:2178542 (MGI:3834010|PMID:17881525) RGD PMID:17881525 MGI:3834010 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Crh corticotropin releasing hormone involved_in ISO
IDA		 (PMID:12895416) RGD PMID:12895416 PMID:12895416 RGD:8553912 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Crhbp corticotropin releasing hormone binding protein involved_in IEP
ISO
ISS		 PMID:18478589
(MGI:5315362|PMID:12895416)
GO_REF:0000024		 RGD
UniProt		 PMID:12895416 PMID:18478589 GO_REF:0000024 MGI:5315362, RGD:8553722 NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710 		JBrowse link
G Drd1 dopamine receptor D1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2159306 (MGI:3663985|PMID:16908842)		 Ensembl
RGD		 PMID:16908842 GO_REF:0000107 MGI:3663985 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd3 dopamine receptor D3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Drd4 dopamine receptor D4 involved_in IMP
IEA		 GO_REF:0000108 GOC
RGD		 PMID:15476261 GO_REF:0000108, RGD:1600954 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Drd5 dopamine receptor D5 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774 		JBrowse link
G Park7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO MGI:3586448 (MGI:3584207|PMID:15799973) RGD PMID:15799973 MGI:3584207 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase acts_upstream_of_or_within ISO MGI:2678247 (MGI:2675710|PMID:12915482) RGD PMID:12915482 MGI:2675710 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Rasd2 RASD family, member 2 involved_in ISO (MGI:3776692|PMID:18035555), (MGI:3848394|PMID:18845937) RGD PMID:18035555 PMID:18845937 MGI:3776692 MGI:3848394 NCBI chr19:13,594,291...13,605,016
Ensembl chr19:13,594,291...13,605,016 		JBrowse link
G Snca synuclein alpha acts_upstream_of_or_within ISO MGI:1888382|MGI:2389489 (MGI:1352916|PMID:10707987), (MGI:2388931|PMID:12388586) RGD PMID:10707987 PMID:12388586 MGI:1352916 MGI:2388931 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Th tyrosine hydroxylase acts_upstream_of_or_within ISO MGI:1928960 (MGI:2652924|PMID:12604788), (MGI:3052583|PMID:15317940) RGD PMID:12604788 PMID:15317940 MGI:2652924 MGI:3052583 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 acts_upstream_of ISO MGI:1857875 (MGI:1328526|PMID:9886065) RGD PMID:9886065 MGI:1328526 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Park7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO MGI:3579140 (MGI:3578474|PMID:15721235) RGD PMID:15721235 MGI:3578474 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:2678247 (MGI:2675710|PMID:12915482)
GO_REF:0000107		 RGD
Ensembl		 PMID:12915482 GO_REF:0000107 MGI:2675710 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
negative regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snca synuclein alpha involved_in ISO
IEA		 (PMID:12958153)
GO_REF:0000107		 RGD
Ensembl		 PMID:12958153 GO_REF:0000107 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
negative regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnq4 potassium voltage-gated channel subfamily Q member 4 IMP RGD PMID:16775195 RGD:1600308 NCBI chr 5:134,275,145...134,326,992
Ensembl chr 5:134,275,934...134,326,932 		JBrowse link
G Pmch pro-melanin-concentrating hormone IDA RGD PMID:15555641 RGD:1642493 NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP RGD PMID:18764909 RGD:2300272 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 IMP RGD PMID:20730799 RGD:4889470 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
positive regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 acts_upstream_of_or_within ISO MGI:1857875 (MGI:1328526|PMID:9886065) RGD PMID:9886065 MGI:1328526 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Nat8l N-acetyltransferase 8-like involved_in ISO (MGI:4943664|PMID:19014384) RGD PMID:19014384 MGI:4943664 NCBI chr14:76,756,077...76,762,712
Ensembl chr14:76,756,077...76,763,411 		JBrowse link
G Rab3b RAB3B, member RAS oncogene family involved_in ISO
IEA		 (PMID:20007772)
GO_REF:0000107		 RGD
Ensembl		 PMID:20007772 GO_REF:0000107 NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401 		JBrowse link
positive regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 involved_in ISO
IEA		 (MGI:3690676|PMID:16051150)
GO_REF:0000107		 RGD
Ensembl		 PMID:16051150 GO_REF:0000107 MGI:3690676 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO MGI:1926253 (MGI:3574746|PMID:15464132) RGD PMID:15464132 MGI:3574746 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Flot1 flotillin 1 involved_in ISO (MGI:5634885|PMID:21399631) RGD PMID:21399631 MGI:5634885 NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978 		JBrowse link
G Pink1 PTEN induced kinase 1 acts_upstream_of_or_within ISO MGI:3716083 (MGI:3715376|PMID:17563363) RGD PMID:17563363 MGI:3715376 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 acts_upstream_of_or_within ISO MGI:2388386 (MGI:2387277|PMID:12223553) RGD PMID:12223553 MGI:2387277 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Gdnf glial cell derived neurotrophic factor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:8493557)		 UniProt
Ensembl
RGD		 PMID:8493557 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Tor1a torsin family 1, member A involved_in ISO
ISS		 (PMID:15505207)
GO_REF:0000024		 RGD
UniProt		 PMID:15505207 GO_REF:0000024 NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691 		JBrowse link
regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1888407 (MGI:3716008|PMID:16772172)		 Ensembl
RGD		 PMID:16772172 GO_REF:0000107 MGI:3716008 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO MGI:1926253 (MGI:3716008|PMID:16772172) RGD PMID:16772172 MGI:3716008 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Cntnap4 contactin associated protein family member 4 involved_in ISO (MGI:5574524|PMID:24870235) RGD PMID:24870235 MGI:5574524 NCBI chr19:40,568,684...40,861,879
Ensembl chr19:40,568,684...40,854,656 		JBrowse link
G Pnkd PNKD metallo-beta-lactamase domain containing acts_upstream_of_or_within ISO MGI:5006973 (MGI:5466578|PMID:22214848) RGD PMID:22214848 MGI:5466578 NCBI chr 9:75,868,620...75,937,126
Ensembl chr 9:75,867,468...75,937,124 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19527
    cellular process 18201
      cell communication 7664
        cell-cell signaling 1795
          synaptic signaling 953
            trans-synaptic signaling 919
              anterograde trans-synaptic signaling 912
                chemical synaptic transmission 912
                  synaptic transmission, dopaminergic 33
                    dopamine secretion, neurotransmission 0
                    dopamine uptake involved in synaptic transmission + 10
                    negative regulation of synaptic transmission, dopaminergic 4
                    positive regulation of synaptic transmission, dopaminergic 4
                    regulation of synaptic transmission, dopaminergic + 11
Path 2
Term Annotations click to browse term
  biological_process 19527
    biological regulation 13192
      regulation of biological process 12837
        signaling 7532
          cell-cell signaling 1795
            synaptic signaling 953
              trans-synaptic signaling 919
                anterograde trans-synaptic signaling 912
                  chemical synaptic transmission 912
                    synaptic transmission, dopaminergic 33
                      dopamine secretion, neurotransmission 0
                      dopamine uptake involved in synaptic transmission + 10
                      negative regulation of synaptic transmission, dopaminergic 4
                      positive regulation of synaptic transmission, dopaminergic 4
                      regulation of synaptic transmission, dopaminergic + 11
paths to the root