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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, dopaminergic
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Accession:GO:0001963 term browser browse the term
Definition:The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


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synaptic transmission, dopaminergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor acts_upstream_of_or_within ISO MGI:98735 (MGI:2450064|PMID:12538862) RGD PMID:12538862 MGI:2450064 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit acts_upstream_of_or_within ISO MGI:1915568 (MGI:3804503|PMID:18626010) RGD PMID:18626010 MGI:3804503 NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243
JBrowse link
G Cdk5 cyclin-dependent kinase 5 acts_upstream_of_or_within ISO (MGI:3033267|PMID:14769920) RGD PMID:14769920 MGI:3033267 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Crh corticotropin releasing hormone involved_in ISO
IDA
(PMID:12895416) RGD PMID:12895416 PMID:12895416 RGD:8553912 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crhbp corticotropin releasing hormone binding protein involved_in IEP
ISO
ISS
PMID:18478589
(MGI:5315362|PMID:12895416)
GO_REF:0000024
RGD
UniProt
PMID:12895416 PMID:18478589 GO_REF:0000024 MGI:5315362, RGD:8553722 NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710
JBrowse link
G Drd1 dopamine receptor D1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2159306 (MGI:3663985|PMID:16908842)
Ensembl
RGD
PMID:16908842 GO_REF:0000107 MGI:3663985 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Drd4 dopamine receptor D4 involved_in IMP
IEA
GO_REF:0000108 GOC PMID:15476261 GO_REF:0000108, RGD:1600954 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Drd5 dopamine receptor D5 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:72,489,347...72,490,774
Ensembl chr14:72,489,347...72,490,774
JBrowse link
G Park7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO MGI:3586448 (MGI:3584207|PMID:15799973) RGD PMID:15799973 MGI:3584207 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase acts_upstream_of_or_within ISO MGI:2678247 (MGI:2675710|PMID:12915482) RGD PMID:12915482 MGI:2675710 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Rasd2 RASD family, member 2 involved_in ISO (MGI:3776692|PMID:18035555), (MGI:3848394|PMID:18845937) RGD PMID:18035555 PMID:18845937 MGI:3776692 MGI:3848394 NCBI chr19:13,594,291...13,605,016
Ensembl chr19:13,594,291...13,605,016
JBrowse link
G Snca synuclein alpha acts_upstream_of_or_within ISO MGI:1888382|MGI:2389489 (MGI:1352916|PMID:10707987), (MGI:2388931|PMID:12388586) RGD PMID:10707987 PMID:12388586 MGI:1352916 MGI:2388931 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Th tyrosine hydroxylase acts_upstream_of_or_within ISO MGI:1928960 (MGI:2652924|PMID:12604788), (MGI:3052583|PMID:15317940) RGD PMID:12604788 PMID:15317940 MGI:2652924 MGI:3052583 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO MGI:3579140 (MGI:3578474|PMID:15721235) RGD PMID:15721235 MGI:3578474 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase acts_upstream_of_or_within ISO MGI:2678247 (MGI:2675710|PMID:12915482) RGD PMID:12915482 MGI:2675710 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Slc6a2 solute carrier family 6 member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc6a3 solute carrier family 6 member 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
negative regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snca synuclein alpha involved_in ISO (PMID:12958153) RGD PMID:12958153 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
negative regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnq4 potassium voltage-gated channel subfamily Q member 4 involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:16775195 PMID:21873635 RGD:1600308, RGD:13792537 NCBI chr 5:134,275,145...134,326,992
Ensembl chr 5:134,275,934...134,326,932
JBrowse link
G Pmch pro-melanin-concentrating hormone IDA RGD PMID:15555641 RGD:1642493 NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP RGD PMID:18764909 RGD:2300272 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Slc6a4 solute carrier family 6 member 4 IMP RGD PMID:20730799 RGD:4889470 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
positive regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 acts_upstream_of_or_within ISO MGI:1857875 (MGI:1328526|PMID:9886065) RGD PMID:9886065 MGI:1328526 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Nat8l N-acetyltransferase 8-like involved_in ISO (MGI:4943664|PMID:19014384) RGD PMID:19014384 MGI:4943664 NCBI chr14:76,756,077...76,762,712
Ensembl chr14:76,756,077...76,763,411
JBrowse link
G Rab3b RAB3B, member RAS oncogene family involved_in ISO (PMID:20007772) RGD PMID:20007772 NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401
JBrowse link
positive regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 involved_in ISO (MGI:3690676|PMID:16051150) RGD PMID:16051150 MGI:3690676 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO MGI:1926253 (MGI:3574746|PMID:15464132) RGD PMID:15464132 MGI:3574746 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Flot1 flotillin 1 involved_in ISO (MGI:5634885|PMID:21399631) RGD PMID:21399631 MGI:5634885 NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978
JBrowse link
G Pink1 PTEN induced kinase 1 acts_upstream_of_or_within ISO MGI:3716083 (MGI:3715376|PMID:17563363) RGD PMID:17563363 MGI:3715376 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 acts_upstream_of_or_within ISO MGI:2388386 (MGI:2387277|PMID:12223553) RGD PMID:12223553 MGI:2387277 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Gdnf glial cell derived neurotrophic factor involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:8493557)
UniProt
Ensembl
RGD
PMID:8493557 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Tor1a torsin family 1, member A involved_in ISO
ISS
(PMID:15505207)
GO_REF:0000024
RGD
UniProt
PMID:15505207 GO_REF:0000024 NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691
JBrowse link
regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1888407 (MGI:3716008|PMID:16772172)
Ensembl
RGD
PMID:16772172 GO_REF:0000107 MGI:3716008 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO MGI:1926253 (MGI:3716008|PMID:16772172) RGD PMID:16772172 MGI:3716008 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Cntnap4 contactin associated protein family member 4 involved_in ISO (MGI:5574524|PMID:24870235) RGD PMID:24870235 MGI:5574524 NCBI chr19:40,568,684...40,861,879
Ensembl chr19:40,568,684...40,854,656
JBrowse link
G Pnkd PNKD metallo-beta-lactamase domain containing acts_upstream_of_or_within ISO MGI:5006973 (MGI:5466578|PMID:22214848) RGD PMID:22214848 MGI:5466578 NCBI chr 9:75,868,620...75,937,126
Ensembl chr 9:75,867,468...75,937,124
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    signaling 7460
      cell-cell signaling 1735
        synaptic signaling 919
          trans-synaptic signaling 892
            anterograde trans-synaptic signaling 883
              chemical synaptic transmission 883
                synaptic transmission, dopaminergic 32
                  dopamine secretion, neurotransmission 0
                  dopamine uptake involved in synaptic transmission + 10
                  negative regulation of synaptic transmission, dopaminergic 4
                  positive regulation of synaptic transmission, dopaminergic 4
                  regulation of synaptic transmission, dopaminergic + 11
Path 2
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      cell communication 7543
        cell-cell signaling 1735
          synaptic signaling 919
            trans-synaptic signaling 892
              anterograde trans-synaptic signaling 883
                chemical synaptic transmission 883
                  synaptic transmission, dopaminergic 32
                    dopamine secretion, neurotransmission 0
                    dopamine uptake involved in synaptic transmission + 10
                    negative regulation of synaptic transmission, dopaminergic 4
                    positive regulation of synaptic transmission, dopaminergic 4
                    regulation of synaptic transmission, dopaminergic + 11
paths to the root