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ONTOLOGY REPORT - ANNOTATIONS

Term:synaptic transmission, dopaminergic
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Accession:GO:0001963 term browser browse the term
Definition:The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


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synaptic transmission, dopaminergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor acts_upstream_of_or_within ISO
IEA 		MGI:98735 (PMID:12538862)
GO_REF:0000107 		RGD
Ensembl		 PMID:12538862 GO_REF:0000107 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit acts_upstream_of_or_within ISO MGI:1915568 (PMID:18626010) RGD PMID:18626010 NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 acts_upstream_of_or_within ISO
IEA 		(PMID:14769920)
GO_REF:0000107 		RGD
Ensembl		 PMID:14769920 GO_REF:0000107 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Comt catechol-O-methyltransferase acts_upstream_of_or_within ISO MGI:2178542 (PMID:17881525) RGD PMID:17881525 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Crh corticotropin releasing hormone involved_in ISO
IEA
IDA 		(PMID:12895416)
GO_REF:0000107 		RGD
Ensembl		 PMID:12895416 PMID:12895416 GO_REF:0000107, RGD:8553912 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Crhbp corticotropin releasing hormone binding protein involved_in IEP
IEA
ISO
ISS 		PMID:18478589
GO_REF:0000107
(PMID:12895416)
GO_REF:0000024 		Ensembl
RGD
UniProt		 PMID:12895416 PMID:18478589 GO_REF:0000024 GO_REF:0000107, RGD:8553722 NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710 		JBrowse link
G Drd1 dopamine receptor D1 acts_upstream_of_or_within ISO
IEA 		MGI:2159306 (PMID:16908842)
GO_REF:0000107 		RGD
Ensembl		 PMID:16908842 GO_REF:0000107 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd3 dopamine receptor D3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr11:70,385,586...70,437,793
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Drd4 dopamine receptor D4 involved_in IMP
IEA 		GO_REF:0000108 GOC
RGD		 PMID:15476261 GO_REF:0000108, RGD:1600954 NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Drd5 dopamine receptor D5 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774 		JBrowse link
G Park7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO MGI:3586448 (PMID:15799973) RGD PMID:15799973 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase acts_upstream_of_or_within ISO
IEA 		MGI:2678247 (PMID:12915482)
GO_REF:0000107 		RGD
Ensembl		 PMID:12915482 GO_REF:0000107 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Rasd2 RASD family, member 2 involved_in ISO
IEA 		(PMID:18035555), (PMID:18845937)
GO_REF:0000107 		RGD
Ensembl		 PMID:18035555 PMID:18845937 GO_REF:0000107 NCBI chr19:13,594,291...13,605,016
Ensembl chr19:13,594,291...13,605,016 		JBrowse link
G Snca synuclein alpha acts_upstream_of_or_within ISO
IEA 		MGI:1888382|MGI:2389489 (PMID:10707987), (PMID:12388586)
GO_REF:0000107 		RGD
Ensembl		 PMID:10707987 PMID:12388586 GO_REF:0000107 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Th tyrosine hydroxylase acts_upstream_of_or_within ISO MGI:1928960 (PMID:12604788), (PMID:15317940) RGD PMID:12604788 PMID:15317940 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 acts_upstream_of ISO
IEA 		MGI:1857875 (PMID:9886065)
GO_REF:0000107 		RGD
Ensembl		 PMID:9886065 GO_REF:0000107 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Park7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO MGI:3579140 (PMID:15721235) RGD PMID:15721235 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase acts_upstream_of_or_within ISO
IEA 		MGI:2678247 (PMID:12915482)
GO_REF:0000107 		RGD
Ensembl		 PMID:12915482 GO_REF:0000107 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
negative regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snca synuclein alpha involved_in ISO
IEA 		(PMID:12958153)
GO_REF:0000107 		RGD
Ensembl		 PMID:12958153 GO_REF:0000107 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
negative regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnq4 potassium voltage-gated channel subfamily Q member 4 IMP RGD PMID:16775195 RGD:1600308 NCBI chr 5:134,275,145...134,326,992
Ensembl chr 5:134,275,934...134,326,932 		JBrowse link
G Pmch pro-melanin-concentrating hormone involved_in IDA
IBA 		GO_REF:0000033 GO_Central
RGD		 PMID:15555641 GO_REF:0000033, RGD:1642493 NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP RGD PMID:18764909 RGD:2300272 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 IMP RGD PMID:20730799 RGD:4889470 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
positive regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 acts_upstream_of_or_within ISO
IEA 		MGI:1857875 (PMID:9886065)
GO_REF:0000107 		RGD
Ensembl		 PMID:9886065 GO_REF:0000107 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Nat8l N-acetyltransferase 8-like involved_in ISO (PMID:19014384) RGD PMID:19014384 NCBI chr14:76,756,077...76,762,712
Ensembl chr14:76,756,077...76,763,411 		JBrowse link
G Rab3b RAB3B, member RAS oncogene family involved_in ISO
IEA 		(PMID:20007772)
GO_REF:0000107 		RGD
Ensembl		 PMID:20007772 GO_REF:0000107 NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401 		JBrowse link
positive regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 involved_in ISO (PMID:16051150) RGD PMID:16051150 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO MGI:1926253 (PMID:15464132) RGD PMID:15464132 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Flot1 flotillin 1 involved_in ISO
IEA 		(PMID:21399631)
GO_REF:0000107 		RGD
Ensembl		 PMID:21399631 GO_REF:0000107 NCBI chr20:2,922,662...2,932,906
Ensembl chr20:2,917,137...2,927,978 		JBrowse link
G Pink1 PTEN induced kinase 1 acts_upstream_of_or_within ISO
IEA 		MGI:3716083 (PMID:17563363)
GO_REF:0000107 		RGD
Ensembl		 PMID:17563363 GO_REF:0000107 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
regulation of dopamine uptake involved in synaptic transmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 acts_upstream_of_or_within ISO
IEA 		MGI:2388386 (PMID:12223553)
GO_REF:0000107 		RGD
Ensembl		 PMID:12223553 GO_REF:0000107 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Gdnf glial cell derived neurotrophic factor involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:8493557) 		UniProt
Ensembl
RGD		 PMID:8493557 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Tor1a torsin family 1, member A involved_in ISO
IEA
ISS 		(PMID:15505207)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:15505207 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691 		JBrowse link
regulation of synaptic transmission, dopaminergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit acts_upstream_of_or_within ISO
IEA 		MGI:1888407 (PMID:16772172)
GO_REF:0000107 		RGD
Ensembl		 PMID:16772172 GO_REF:0000107 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO MGI:1926253 (PMID:16772172) RGD PMID:16772172 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Cntnap4 contactin associated protein family member 4 involved_in ISO (PMID:24870235) RGD PMID:24870235 NCBI chr19:40,568,684...40,861,879
Ensembl chr19:40,568,684...40,854,656 		JBrowse link
G Pnkd PNKD metallo-beta-lactamase domain containing acts_upstream_of_or_within ISO
IEA 		MGI:5006973 (PMID:22214848)
GO_REF:0000107 		RGD
Ensembl		 PMID:22214848 GO_REF:0000107 NCBI chr 9:75,868,620...75,937,126
Ensembl chr 9:75,867,468...75,937,124 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      cell communication 7907
        cell-cell signaling 1491
          synaptic signaling 1011
            trans-synaptic signaling 967
              anterograde trans-synaptic signaling 959
                chemical synaptic transmission 959
                  synaptic transmission, dopaminergic 32
                    dopamine secretion, neurotransmission 0
                    dopamine uptake involved in synaptic transmission + 9
                    negative regulation of synaptic transmission, dopaminergic 4
                    positive regulation of synaptic transmission, dopaminergic 4
                    regulation of synaptic transmission, dopaminergic + 11
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        signaling 7874
          cell-cell signaling 1491
            synaptic signaling 1011
              trans-synaptic signaling 967
                anterograde trans-synaptic signaling 959
                  chemical synaptic transmission 959
                    synaptic transmission, dopaminergic 32
                      dopamine secretion, neurotransmission 0
                      dopamine uptake involved in synaptic transmission + 9
                      negative regulation of synaptic transmission, dopaminergic 4
                      positive regulation of synaptic transmission, dopaminergic 4
                      regulation of synaptic transmission, dopaminergic + 11
paths to the root