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ONTOLOGY REPORT - ANNOTATIONS

Term:heart looping
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Accession:GO:0001947 term browser browse the term
Definition:The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceding septation.
Synonyms:exact_synonym: cardiac looping


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heart looping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07063281.1 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Ahi1 Abelson helper integration site 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:15,762,485...15,891,213
Ensembl chr 1:15,762,462...15,891,041 		JBrowse link
G Aplnr apelin receptor involved_in ISO
IEA 		(PMID:23603510)
GO_REF:0000107 		RGD
Ensembl		 PMID:23603510 GO_REF:0000107 NCBI chr 3:90,624,055...90,627,700
Ensembl chr 3:70,217,385...70,221,050 		JBrowse link
G Arl13b ARF like GTPase 13B acts_upstream_of_or_within ISO
IEA 		MGI:3578151 (PMID:22554696)
GO_REF:0000107 		RGD
Ensembl		 PMID:22554696 GO_REF:0000107 NCBI chr11:150,100...217,103
Ensembl chr11:150,955...217,197 		JBrowse link
G Asb2 ankyrin repeat and SOCS box-containing 2 involved_in ISO (PMID:32179481) RGD PMID:32179481 NCBI chr 6:122,474,754...122,511,014
Ensembl chr 6:122,474,756...122,510,854 		JBrowse link
G C2cd3 C2 domain containing 3 centriole elongation regulator acts_upstream_of_or_within ISO (PMID:19004860) RGD PMID:19004860 NCBI chr 1:154,715,151...154,812,955
Ensembl chr 1:154,715,310...154,812,520 		JBrowse link
G Ccdc39 coiled-coil domain 39 molecular ruler complex subunit involved_in ISO
IEA 		(PMID:22693285)
GO_REF:0000107 		RGD
Ensembl		 PMID:22693285 GO_REF:0000107 NCBI chr 2:118,593,881...118,631,584
Ensembl chr 2:116,665,261...116,703,350 		JBrowse link
G Ccdc40 coiled-coil domain 40 molecular ruler complex subunit involved_in ISO
IEA
IBA 		(PMID:22693285)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:22693285 GO_REF:0000033 GO_REF:0000107 NCBI chr10:104,486,748...104,527,284
Ensembl chr10:104,486,748...104,527,243 		JBrowse link
G Cfc1 cripto, FRL-1, cryptic family 1 acts_upstream_of_or_within ISO
IEA 		MGI:2179530 (PMID:10521397)
GO_REF:0000107 		RGD
Ensembl		 PMID:10521397 GO_REF:0000107 NCBI chr 9:36,742,106...36,751,931
Ensembl chr 9:36,739,071...36,751,930 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 acts_upstream_of_or_within ISO MGI:2176158 (PMID:15750185) RGD PMID:15750185 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Cluap1 clusterin associated protein 1 acts_upstream_of_or_within ISO MGI:5523142 (PMID:23742838) RGD PMID:23742838 NCBI chr10:11,587,963...11,619,711
Ensembl chr10:11,588,017...11,619,711 		JBrowse link
G Dll1 delta like canonical Notch ligand 1 involved_in ISO (PMID:12730124) RGD PMID:12730124 NCBI chr 1:64,985,161...64,993,274
Ensembl chr 1:56,312,066...56,320,179 		JBrowse link
G Dnaaf1 dynein, axonemal, assembly factor 1 involved_in ISO
IEA 		(PMID:19944400), (PMID:19944405)
GO_REF:0000107 		RGD
Ensembl		 PMID:19944400 PMID:19944405 GO_REF:0000107 NCBI chr19:47,624,534...47,652,314
Ensembl chr19:47,624,181...47,652,313 		JBrowse link
G Dnaaf19 dynein axonemal assembly factor 19 involved_in ISO
IEA 		(PMID:22581229)
GO_REF:0000107 		RGD
Ensembl		 PMID:22581229 GO_REF:0000107 NCBI chr10:87,846,327...87,849,959
Ensembl chr10:87,846,357...87,849,757 		JBrowse link
G Dvl1 dishevelled segment polarity protein 1 involved_in ISO
IEA 		UniProtKB:Q60838 (PMID:22841628)
GO_REF:0000107 		RGD
Ensembl		 PMID:22841628 GO_REF:0000107 NCBI chr 5:171,738,911...171,750,967
Ensembl chr 5:166,456,686...166,468,664 		JBrowse link
G Dvl2 dishevelled segment polarity protein 2 involved_in ISO
IEA 		UniProtKB:P51141 (PMID:22841628)
GO_REF:0000107 		RGD
Ensembl		 PMID:22841628 GO_REF:0000107 NCBI chr10:55,222,245...55,231,506
Ensembl chr10:54,723,411...54,732,820 		JBrowse link
G Eng endoglin involved_in ISO (PMID:10348742), (PMID:19703439) RGD PMID:10348742 PMID:19703439 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Fgf8 fibroblast growth factor 8 acts_upstream_of_or_within ISO
IEA 		MGI:1857843 (PMID:10411502)
GO_REF:0000107 		RGD
Ensembl		 PMID:10411502 GO_REF:0000107 NCBI chr 1:254,533,504...254,539,605
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Folr1 folate receptor alpha involved_in ISO
IEA 		(PMID:17286298)
GO_REF:0000107 		RGD
Ensembl		 PMID:17286298 GO_REF:0000107 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667 		JBrowse link
G Foxh1 forkhead box H1 involved_in ISO
IEA 		(PMID:15363409)
GO_REF:0000107 		RGD
Ensembl		 PMID:15363409 GO_REF:0000107 NCBI chr 7:108,387,969...108,391,566
Ensembl chr 7:108,387,969...108,390,049 		JBrowse link
G Gata4 GATA binding protein 4 involved_in ISO (PMID:15310850) RGD PMID:15310850 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gja1 gap junction protein, alpha 1 acts_upstream_of_or_within ISO MGI:1857177 (PMID:9486664) RGD PMID:9486664 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Hand1 heart and neural crest derivatives expressed 1 acts_upstream_of_or_within ISO
IEA 		MGI:2153823 (PMID:9500551)
GO_REF:0000107 		RGD
Ensembl		 PMID:9500551 GO_REF:0000107 NCBI chr10:42,006,646...42,009,213
Ensembl chr10:42,006,651...42,009,213 		JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 acts_upstream_of_or_within ISO
IEA 		MGI:1857639 (PMID:9171826)
GO_REF:0000107 		RGD
Ensembl		 PMID:9171826 GO_REF:0000107 NCBI chr16:37,928,145...37,931,488
Ensembl chr16:32,917,823...32,919,891 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha acts_upstream_of_or_within ISO
IEA 		MGI:2179429 (PMID:14659802)
GO_REF:0000107 		RGD
Ensembl		 PMID:14659802 GO_REF:0000107 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Ift172 intraflagellar transport 172 acts_upstream_of_or_within ISO
IEA 		MGI:3829198 (PMID:18930042)
GO_REF:0000107 		RGD
Ensembl		 PMID:18930042 GO_REF:0000107 NCBI chr 6:30,801,841...30,841,239
Ensembl chr 6:25,081,980...25,120,860 		JBrowse link
G Ift52 intraflagellar transport 52 acts_upstream_of_or_within ISO
IEA 		(PMID:15930098)
GO_REF:0000107 		RGD
Ensembl		 PMID:15930098 GO_REF:0000107 NCBI chr 3:151,672,505...151,696,975
Ensembl chr 3:151,672,493...151,696,980 		JBrowse link
G Ift57 intraflagellar transport 57 acts_upstream_of_or_within ISO
IEA 		MGI:3707373 (PMID:17027958)
GO_REF:0000107 		RGD
Ensembl		 PMID:17027958 GO_REF:0000107 NCBI chr11:51,051,520...51,124,909
Ensembl chr11:51,059,611...51,124,812 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO
IEA 		(PMID:11517919)
GO_REF:0000107 		RGD
Ensembl		 PMID:11517919 GO_REF:0000107 NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:76,504,315...76,510,532 		JBrowse link
G Kdm2a lysine demethylase 2A acts_upstream_of_or_within ISO (PMID:25463925) RGD PMID:25463925 NCBI chr 1:211,041,859...211,125,749
Ensembl chr 1:201,612,453...201,680,787 		JBrowse link
G Kif3a kinesin family member 3a acts_upstream_of_or_within ISO MGI:2181727 (PMID:10330409) RGD PMID:10330409 NCBI chr10:38,226,388...38,263,062
Ensembl chr10:37,725,970...37,759,191 		JBrowse link
G Lbx1 ladybird homeobox 1 acts_upstream_of_or_within ISO
IEA 		MGI:2386948 (PMID:12522123)
GO_REF:0000107 		RGD
Ensembl		 PMID:12522123 GO_REF:0000107 NCBI chr 1:244,083,873...244,085,690
Ensembl chr 1:244,083,873...244,085,690 		JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:98958 (PMID:19795512) RGD PMID:19795512 NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO 		GO_REF:0000024
(PMID:16680724) 		UniProt
RGD		 PMID:16680724 GO_REF:0000024 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO
IEA 		(PMID:10393122)
GO_REF:0000107 		RGD
Ensembl		 PMID:10393122 GO_REF:0000107 NCBI chr 1:143,147,671...143,149,189
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
G Mib1 MIB E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO
IEA 		MGI:3603514 (PMID:16000382)
GO_REF:0000107 		RGD
Ensembl		 PMID:16000382 GO_REF:0000107 NCBI chr18:1,802,519...1,926,988
Ensembl chr18:1,802,519...1,920,689 		JBrowse link
G Mical2 microtubule associated monooxygenase, calponin and LIM domain containing 2 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:166,345,853...166,530,575
Ensembl chr 1:166,345,859...166,471,719
Ensembl chr 1:166,345,859...166,471,719 		JBrowse link
G Nkx2-5 NK2 homeobox 5 acts_upstream_of_or_within ISO
IEA 		MGI:1927227 (PMID:16510504), (PMID:7628699), (PMID:9192865)
GO_REF:0000107 		RGD
Ensembl		 PMID:7628699 PMID:9192865 PMID:16510504 GO_REF:0000107 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934 		JBrowse link
G Nodal nodal growth differentiation factor acts_upstream_of_or_within ISO
IEA 		MGI:106676 (PMID:16496285)
GO_REF:0000107 		RGD
Ensembl		 PMID:16496285 GO_REF:0000107 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO
IEA 		UniProtKB:O35516 (PMID:12730124)
GO_REF:0000107 		RGD
Ensembl		 PMID:12730124 GO_REF:0000107 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Notch2 notch receptor 2 involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:Q01705 (PMID:12730124) 		Ensembl
RGD		 PMID:12730124 GO_REF:0000107 NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:185,610,589...185,744,088 		JBrowse link
G Noto notochord homeobox acts_upstream_of_or_within ISO
IEA 		MGI:3053092 (PMID:17884984)
GO_REF:0000107 		RGD
Ensembl		 PMID:17884984 GO_REF:0000107 NCBI chr 4:117,961,163...117,965,402
Ensembl chr 4:117,961,163...117,965,402 		JBrowse link
G Nphp3 nephrocystin 3 involved_in ISO
IEA 		(PMID:18371931), (PMID:20007846)
GO_REF:0000107 		RGD
Ensembl		 PMID:18371931 PMID:20007846 GO_REF:0000107 NCBI chr 8:104,621,908...104,662,383
Ensembl chr 8:104,621,864...104,662,383 		JBrowse link
G Ovol2 ovo-like zinc finger 2 acts_upstream_of_or_within ISO
IEA 		MGI:3777011 (PMID:17573777)
GO_REF:0000107 		RGD
Ensembl		 PMID:17573777 GO_REF:0000107 NCBI chr 3:131,677,391...131,707,123
Ensembl chr 3:131,677,391...131,708,359 		JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel involved_in ISO (PMID:21719175) RGD PMID:21719175 NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825 		JBrowse link
G Psen1 presenilin 1 acts_upstream_of_or_within ISO
IEA 		MGI:109284 (PMID:10557208)
GO_REF:0000107 		RGD
Ensembl		 PMID:10557208 GO_REF:0000107 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Shh sonic hedgehog signaling molecule acts_upstream_of_or_within
involved_in 		ISO
IEA 		MGI:1857796 (PMID:10411502), (PMID:10500184)
(PMID:11517919)
GO_REF:0000107 		RGD
Ensembl		 PMID:10411502 PMID:10500184 PMID:11517919 GO_REF:0000107 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Smad3 SMAD family member 3 acts_upstream_of_or_within ISO
IEA 		MGI:108051 (PMID:15183723)
GO_REF:0000107 		RGD
Ensembl		 PMID:15183723 GO_REF:0000107 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smo smoothened, frizzled class receptor involved_in IEA
ISS
ISO 		GO_REF:0000107
GO_REF:0000024
(PMID:11517919) 		Ensembl
UniProt
RGD		 PMID:11517919 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Sox17 SRY-box transcription factor 17 acts_upstream_of_or_within
involved_in 		ISO
IEA 		MGI:2179440 (PMID:17610846)
(PMID:17610846), (PMID:17655922)
GO_REF:0000107 		RGD
Ensembl		 PMID:17610846 PMID:17655922 GO_REF:0000107 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
G Srf serum response factor acts_upstream_of_or_within ISO
IEA 		MGI:2385465|MGI:2386742 (PMID:15929941)
GO_REF:0000107 		RGD
Ensembl		 PMID:15929941 GO_REF:0000107 NCBI chr 9:21,924,050...21,933,338
Ensembl chr 9:14,426,472...14,435,733 		JBrowse link
G Stil STIL, centriolar assembly protein acts_upstream_of_or_within ISO MGI:2152962 (PMID:10385121) RGD PMID:10385121 NCBI chr 5:133,757,598...133,810,493
Ensembl chr 5:128,520,953...128,573,730 		JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling acts_upstream_of_or_within ISO
IEA 		MGI:3512046 (PMID:16155214)
GO_REF:0000107 		RGD
Ensembl		 PMID:16155214 GO_REF:0000107 NCBI chr 1:255,199,108...255,296,983
Ensembl chr 1:245,257,768...245,355,577 		JBrowse link
G Tbx20 T-box transcription factor 20 acts_upstream_of_or_within
involved_in 		ISO
IBA
IEA 		MGI:3579849|MGI:3580099 (PMID:15843407), (PMID:15901664)
(PMID:15843409)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:15843407 PMID:15843409 PMID:15901664 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:31,475,963...31,534,051
Ensembl chr 8:23,204,507...23,258,175 		JBrowse link
G Tbx3 T-box transcription factor 3 acts_upstream_of_or_within ISO
IEA 		MGI:2655214|MGI:3769504 (PMID:17460765), (PMID:18723448)
GO_REF:0000107 		RGD
Ensembl		 PMID:17460765 PMID:18723448 GO_REF:0000107 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in ISO
IEA 		(PMID:17050629)
GO_REF:0000107 		RGD
Ensembl		 PMID:17050629 GO_REF:0000107 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO
IEA 		MGI:4343479|MGI:4456438 (PMID:20178780)
GO_REF:0000107 		RGD
Ensembl		 PMID:20178780 GO_REF:0000107 NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 involved_in ISO
IEA 		(PMID:11440971)
GO_REF:0000107 		RGD
Ensembl		 PMID:11440971 GO_REF:0000107 NCBI chr13:84,462,731...84,489,404
Ensembl chr13:84,465,527...84,489,378 		JBrowse link
G Wnt3a Wnt family member 3A acts_upstream_of_or_within ISO
IEA 		MGI:1857489 (PMID:16291790)
GO_REF:0000107 		RGD
Ensembl		 PMID:16291790 GO_REF:0000107 NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
G Wnt5a Wnt family member 5A acts_upstream_of_or_within ISO
IEA 		MGI:1298218 (PMID:19795512)
GO_REF:0000107 		RGD
Ensembl		 PMID:19795512 GO_REF:0000107 NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
G Zic3 Zic family member 3 involved_in
acts_upstream_of_or_within 		ISO (PMID:9354794)
MGI:2180720|MGI:3043027|MGI:97359 (PMID:15384171), (PMID:16496285) 		RGD PMID:9354794 PMID:15384171 PMID:16496285 NCBI chr  X:136,123,662...136,129,627
Ensembl chr  X:136,124,026...136,134,746 		JBrowse link
negative regulation of heart looping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tbx2 T-box transcription factor 2 involved_in ISO
IEA 		(PMID:15042700)
GO_REF:0000107 		RGD
Ensembl		 PMID:15042700 GO_REF:0000107 NCBI chr10:71,177,082...71,186,275
Ensembl chr10:70,679,518...70,688,529 		JBrowse link
regulation of heart looping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf207 ring finger protein 207 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:162,815,351...162,828,325
Ensembl chr 5:162,815,357...162,828,375 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    developmental process 7160
      anatomical structure morphogenesis 3019
        embryonic morphogenesis 708
          embryonic heart tube morphogenesis 70
            heart looping 63
              negative regulation of heart looping 1
              positive regulation of heart looping 0
              regulation of heart looping + 2
Path 2
Term Annotations click to browse term
  biological_process 20543
    developmental process 7160
      anatomical structure development 6656
        multicellular organism development 5362
          system development 4644
            circulatory system development 1387
              heart development 750
                embryonic heart tube development 95
                  embryonic heart tube morphogenesis 70
                    heart looping 63
                      negative regulation of heart looping 1
                      positive regulation of heart looping 0
                      regulation of heart looping + 2
paths to the root