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ONTOLOGY REPORT - ANNOTATIONS

Term:B-1 B cell differentiation
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Accession:GO:0001923 term browser browse the term
Definition:The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
Synonyms:exact_synonym: B-1 B-lymphocyte differentiation
 related_synonym: B-1 B cell development

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B-1 B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd19 CD19 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:11,793,903...11,807,410
Ensembl chrNW_004936501:11,793,891...11,804,162 		JBrowse link
G Malt1 MALT1 paracaspase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:5,854,361...5,910,719
Ensembl chrNW_004936497:5,853,870...5,904,266 		JBrowse link
B-1 B cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slamf8 SLAM family member 8 involved_in ISO (PMID:11313408) UniProt PMID:11313408 NCBI chrNW_004936740:776,557...786,182
Ensembl chrNW_004936740:776,455...786,357 		JBrowse link
B-1a B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmtm7 CKLF like MARVEL transmembrane domain containing 7 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:22,932,965...22,947,309
Ensembl chrNW_004936473:22,937,056...22,947,381 		JBrowse link
G Dpp4 dipeptidyl peptidase 4 ISO RGD PMID:19327106 RGD:41408336 NCBI chrNW_004936469:16,979,220...17,062,198
Ensembl chrNW_004936469:16,979,410...17,061,159 		JBrowse link
G Nfatc1 nuclear factor of activated T cells 1 acts_upstream_of_or_within ISO (PMID:14595020) MGI PMID:14595020 NCBI chrNW_004936616:484,062...584,950
Ensembl chrNW_004936616:484,045...587,891 		JBrowse link
G Plcl2 phospholipase C like 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:9,628,612...9,801,713
Ensembl chrNW_004936473:9,627,811...9,802,132 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17417
    immune system process 2307
      leukocyte activation 950
        lymphocyte activation 775
          lymphocyte differentiation 416
            B cell differentiation 146
              mature B cell differentiation 45
                B-1 B cell differentiation 7
                  B-1 B cell lineage commitment 1
                  B-1a B cell differentiation 4
                  B-1b B cell differentiation 0
                  negative regulation of B-1 B cell differentiation 0
                  positive regulation of B-1 B cell differentiation 0
                  regulation of B-1 B cell differentiation + 0
Path 2
Term Annotations click to browse term
  biological_process 17417
    developmental process 6454
      cellular developmental process 4354
        cell differentiation 4353
          cell development 3128
            hemopoiesis 989
              leukocyte differentiation 633
                mononuclear cell differentiation 511
                  lymphocyte differentiation 416
                    B cell differentiation 146
                      mature B cell differentiation 45
                        B-1 B cell differentiation 7
                          B-1 B cell lineage commitment 1
                          B-1a B cell differentiation 4
                          B-1b B cell differentiation 0
                          negative regulation of B-1 B cell differentiation 0
                          positive regulation of B-1 B cell differentiation 0
                          regulation of B-1 B cell differentiation + 0
paths to the root