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ONTOLOGY REPORT - ANNOTATIONS

Term:B-1 B cell differentiation
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Accession:GO:0001923 term browser browse the term
Definition:The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
Synonyms:exact_synonym: B-1 B-lymphocyte differentiation
 related_synonym: B-1 B cell development


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B-1 B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD19 CD19 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:18,592,785...18,601,273
Ensembl chr 3:18,592,880...18,601,263 		JBrowse link
G MALT1 MALT1 paracaspase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14614861) Ensembl
MGI		 PMID:14614861 GO_REF:0000107 NCBI chr 1:162,076,933...162,144,915
Ensembl chr 1:162,076,955...162,144,880 		JBrowse link
B-1 B cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLAMF8 SLAM family member 8 involved_in ISO (PMID:11313408) UniProt PMID:11313408 NCBI chr 4:90,661,984...90,673,044
Ensembl chr 4:90,661,985...90,672,572 		JBrowse link
B-1a B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMTM7 CKLF like MARVEL transmembrane domain containing 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24080084) Ensembl
MGI		 PMID:24080084 GO_REF:0000107 NCBI chr13:18,371,327...18,424,132
Ensembl chr13:18,412,215...18,424,122 		JBrowse link
G DPP4 dipeptidyl peptidase 4 ISO RGD PMID:19327106 RGD:41408336 NCBI chr15:68,661,764...68,742,961
Ensembl chr15:68,660,521...68,743,663 		JBrowse link
G NFATC1 nuclear factor of activated T cells 1 acts_upstream_of_or_within ISO (PMID:14595020) MGI PMID:14595020 NCBI chr 1:145,940,099...146,002,897
Ensembl chr 1:145,911,046...146,008,139 		JBrowse link
G PLCL2 phospholipase C like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14517301) Ensembl
MGI		 PMID:14517301 GO_REF:0000107 NCBI chr13:3,992,230...4,201,574
Ensembl chr13:3,992,835...4,201,569 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18943
    immune system process 2582
      leukocyte activation 1056
        lymphocyte activation 866
          lymphocyte differentiation 451
            B cell differentiation 152
              mature B cell differentiation 43
                B-1 B cell differentiation 7
                  B-1 B cell lineage commitment 1
                  B-1a B cell differentiation 4
                  B-1b B cell differentiation 0
                  negative regulation of B-1 B cell differentiation 0
                  positive regulation of B-1 B cell differentiation 0
                  regulation of B-1 B cell differentiation + 0
Path 2
Term Annotations click to browse term
  biological_process 18943
    developmental process 6789
      cellular developmental process 4584
        cell differentiation 4583
          cell development 3254
            hemopoiesis 1046
              leukocyte differentiation 674
                mononuclear cell differentiation 548
                  lymphocyte differentiation 451
                    B cell differentiation 152
                      mature B cell differentiation 43
                        B-1 B cell differentiation 7
                          B-1 B cell lineage commitment 1
                          B-1a B cell differentiation 4
                          B-1b B cell differentiation 0
                          negative regulation of B-1 B cell differentiation 0
                          positive regulation of B-1 B cell differentiation 0
                          regulation of B-1 B cell differentiation + 0
paths to the root