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ONTOLOGY REPORT - ANNOTATIONS

Term:B-1 B cell differentiation
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Accession:GO:0001923 term browser browse the term
Definition:The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
Synonyms:exact_synonym: B-1 B-lymphocyte differentiation
 related_synonym: B-1 B cell development

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B-1 B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd19 CD19 molecule involved_in ISO (PMID:7543183) UniProt PMID:7543183 NCBI chrNW_004624782:12,844,148...12,850,770
Ensembl chrNW_004624782:12,845,432...12,850,576 		JBrowse link
G Malt1 MALT1 paracaspase acts_upstream_of_or_within ISO (PMID:14614861) MGI PMID:14614861 NCBI chrNW_004624792:4,148,258...4,223,431
Ensembl chrNW_004624792:4,148,453...4,217,548 		JBrowse link
B-1 B cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slamf8 SLAM family member 8 involved_in ISO (PMID:11313408) UniProt PMID:11313408 NCBI chrNW_004624794:1,418,727...1,428,836
Ensembl chrNW_004624794:1,418,228...1,429,561 		JBrowse link
B-1a B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmtm7 CKLF like MARVEL transmembrane domain containing 7 acts_upstream_of_or_within ISO (PMID:24080084) MGI PMID:24080084 NCBI chrNW_004624788:10,477,476...10,523,506
Ensembl chrNW_004624788:10,477,355...10,523,596 		JBrowse link
G Dpp4 dipeptidyl peptidase 4 ISO RGD PMID:19327106 RGD:41408336 NCBI chrNW_004624732:3,460,529...3,535,252
Ensembl chrNW_004624732:3,460,118...3,535,249 		JBrowse link
G Nfatc1 nuclear factor of activated T cells 1 acts_upstream_of_or_within ISO (PMID:14595020) MGI PMID:14595020 NCBI chrNW_004624806:905,487...1,022,784
Ensembl chrNW_004624806:905,174...1,022,800 		JBrowse link
G Plcl2 phospholipase C like 2 acts_upstream_of_or_within ISO (PMID:14517301) MGI PMID:14517301 NCBI chrNW_004624821:2,132,075...2,316,624
Ensembl chrNW_004624821:2,131,851...2,315,934 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17653
    immune system process 2285
      leukocyte activation 927
        lymphocyte activation 752
          lymphocyte differentiation 403
            B cell differentiation 138
              mature B cell differentiation 41
                B-1 B cell differentiation 7
                  B-1 B cell lineage commitment 1
                  B-1a B cell differentiation 4
                  B-1b B cell differentiation 0
                  negative regulation of B-1 B cell differentiation 0
                  positive regulation of B-1 B cell differentiation 0
                  regulation of B-1 B cell differentiation + 0
Path 2
Term Annotations click to browse term
  biological_process 17653
    developmental process 6427
      cellular developmental process 4326
        cell differentiation 4325
          cell development 3071
            hemopoiesis 949
              leukocyte differentiation 611
                mononuclear cell differentiation 495
                  lymphocyte differentiation 403
                    B cell differentiation 138
                      mature B cell differentiation 41
                        B-1 B cell differentiation 7
                          B-1 B cell lineage commitment 1
                          B-1a B cell differentiation 4
                          B-1b B cell differentiation 0
                          negative regulation of B-1 B cell differentiation 0
                          positive regulation of B-1 B cell differentiation 0
                          regulation of B-1 B cell differentiation + 0
paths to the root