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ONTOLOGY REPORT - ANNOTATIONS

Term:B-1 B cell differentiation
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Accession:GO:0001923 term browser browse the term
Definition:The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
Synonyms:exact_synonym: B-1 B-lymphocyte differentiation
 related_synonym: B-1 B cell development


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B-1 B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD19 CD19 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:28,931,971...28,939,342
Ensembl chr16:28,931,965...28,939,342 		JBrowse link
G MALT1 MALT1 paracaspase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr18:58,671,465...58,754,477
Ensembl chr18:58,671,465...58,754,477 		JBrowse link
B-1 B cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLAMF8 SLAM family member 8 involved_in ISS (PMID:11313408) UniProt PMID:11313408 NCBI chr 1:159,826,873...159,837,492
Ensembl chr 1:159,826,811...159,837,492 		JBrowse link
B-1a B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMTM7 CKLF like MARVEL transmembrane domain containing 7 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:32,391,853...32,455,528
Ensembl chr 3:32,391,698...32,483,067 		JBrowse link
G DPP4 dipeptidyl peptidase 4 ISO RGD PMID:19327106 RGD:41408336 NCBI chr 2:161,992,245...162,074,215
Ensembl chr 2:161,992,245...162,074,394 		JBrowse link
G NFATC1 nuclear factor of activated T cells 1 acts_upstream_of_or_within ISO (PMID:14595020) MGI PMID:14595020 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325 		JBrowse link
G PLCL2 phospholipase C like 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:16,884,955...17,090,606
Ensembl chr 3:16,802,651...17,090,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 27142
    immune system process 3306
      leukocyte activation 1157
        lymphocyte activation 950
          lymphocyte differentiation 509
            B cell differentiation 177
              mature B cell differentiation 47
                B-1 B cell differentiation 7
                  B-1 B cell lineage commitment 1
                  B-1a B cell differentiation 4
                  B-1b B cell differentiation 0
                  negative regulation of B-1 B cell differentiation 0
                  positive regulation of B-1 B cell differentiation 0
                  regulation of B-1 B cell differentiation + 0
Path 2
Term Annotations click to browse term
  biological_process 27142
    developmental process 7762
      cellular developmental process 5253
        cell differentiation 5252
          cell development 3497
            hemopoiesis 1180
              leukocyte differentiation 755
                mononuclear cell differentiation 621
                  lymphocyte differentiation 509
                    B cell differentiation 177
                      mature B cell differentiation 47
                        B-1 B cell differentiation 7
                          B-1 B cell lineage commitment 1
                          B-1a B cell differentiation 4
                          B-1b B cell differentiation 0
                          negative regulation of B-1 B cell differentiation 0
                          positive regulation of B-1 B cell differentiation 0
                          regulation of B-1 B cell differentiation + 0
paths to the root