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ONTOLOGY REPORT - ANNOTATIONS

Term:B-1 B cell differentiation
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Accession:GO:0001923 term browser browse the term
Definition:The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
Synonyms:exact_synonym: B-1 B-lymphocyte differentiation
 related_synonym: B-1 B cell development

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B-1 B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD19 CD19 molecule involved_in ISO (PMID:7543183) UniProt PMID:7543183 NCBI chr 5:26,140,703...26,145,447 JBrowse link
G MALT1 MALT1 paracaspase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr18:20,984,985...21,064,198
Ensembl chr18:20,985,819...21,054,554 		JBrowse link
B-1 B cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103223747 SLAM family member 8 involved_in ISO (PMID:11313408) UniProt PMID:11313408 NCBI chr20:4,114,403...4,127,122
Ensembl chr20:4,116,630...4,124,988 		JBrowse link
B-1a B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMTM7 CKLF like MARVEL transmembrane domain containing 7 acts_upstream_of_or_within ISO (PMID:24080084) MGI PMID:24080084 NCBI chr15:76,896,216...76,960,117 JBrowse link
G CMTM7 CKLF like MARVEL transmembrane domain containing 7 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr15:76,896,553...76,959,017 JBrowse link
G DPP4 dipeptidyl peptidase 4 ISO RGD PMID:19327106 RGD:41408336 NCBI chr10:47,396,605...47,481,478
Ensembl chr10:47,394,093...47,480,893 		JBrowse link
G NFATC1 nuclear factor of activated T cells 1 acts_upstream_of_or_within ISO (PMID:14595020) MGI PMID:14595020 NCBI chr18:690,313...815,804
Ensembl chr18:689,671...811,100 		JBrowse link
G PLCL2 phospholipase C like 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr15:61,745,338...61,940,176
Ensembl chr15:61,745,163...61,942,655 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19829
    immune system process 2687
      leukocyte activation 1043
        lymphocyte activation 854
          lymphocyte differentiation 459
            B cell differentiation 163
              mature B cell differentiation 50
                B-1 B cell differentiation 8
                  B-1 B cell lineage commitment 1
                  B-1a B cell differentiation 5
                  B-1b B cell differentiation 0
                  negative regulation of B-1 B cell differentiation 0
                  positive regulation of B-1 B cell differentiation 0
                  regulation of B-1 B cell differentiation + 0
Path 2
Term Annotations click to browse term
  biological_process 19829
    developmental process 6876
      cellular developmental process 4609
        cell differentiation 4608
          cell development 3290
            hemopoiesis 1062
              leukocyte differentiation 690
                mononuclear cell differentiation 560
                  lymphocyte differentiation 459
                    B cell differentiation 163
                      mature B cell differentiation 50
                        B-1 B cell differentiation 8
                          B-1 B cell lineage commitment 1
                          B-1a B cell differentiation 5
                          B-1b B cell differentiation 0
                          negative regulation of B-1 B cell differentiation 0
                          positive regulation of B-1 B cell differentiation 0
                          regulation of B-1 B cell differentiation + 0
paths to the root