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ONTOLOGY REPORT - ANNOTATIONS

Term:B-1 B cell differentiation
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Accession:GO:0001923 term browser browse the term
Definition:The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
Synonyms:exact_synonym: B-1 B-lymphocyte differentiation
 related_synonym: B-1 B cell development


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B-1 B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD19 CD19 molecule involved_in ISO (PMID:7543183) UniProt PMID:7543183 Ensembl chr16:29,320,734...29,327,481 JBrowse link
G MALT1 MALT1 paracaspase acts_upstream_of_or_within ISO (PMID:14614861) MGI PMID:14614861 NCBI chr18:52,060,878...52,141,985
Ensembl chr18:55,395,462...55,473,574 		JBrowse link
B-1 B cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLAMF8 SLAM family member 8 involved_in ISO (PMID:11313408) UniProt PMID:11313408 NCBI chr 1:135,178,241...135,189,005 JBrowse link
B-1a B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMTM7 CKLF like MARVEL transmembrane domain containing 7 acts_upstream_of_or_within ISO (PMID:24080084) MGI PMID:24080084 NCBI chr 3:32,308,975...32,372,711 JBrowse link
G DPP4 dipeptidyl peptidase 4 ISO RGD PMID:19327106 RGD:41408336 NCBI chr2B:49,285,685...49,368,056
Ensembl chr2B:166,654,659...166,736,588 		JBrowse link
G NFATC1 nuclear factor of activated T cells 1 acts_upstream_of_or_within ISO (PMID:14595020) MGI PMID:14595020 NCBI chr18:72,948,067...73,083,180
Ensembl chr18:76,017,454...76,094,453 		JBrowse link
G PLCL2 phospholipase C like 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:16,736,430...17,015,531
Ensembl chr 3:17,154,500...17,351,287 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    immune system process 2521
      leukocyte activation 1005
        lymphocyte activation 816
          lymphocyte differentiation 434
            B cell differentiation 147
              mature B cell differentiation 46
                B-1 B cell differentiation 7
                  B-1 B cell lineage commitment 1
                  B-1a B cell differentiation 4
                  B-1b B cell differentiation 0
                  negative regulation of B-1 B cell differentiation 0
                  positive regulation of B-1 B cell differentiation 0
                  regulation of B-1 B cell differentiation + 0
Path 2
Term Annotations click to browse term
  biological_process 19315
    developmental process 6685
      cellular developmental process 4499
        cell differentiation 4498
          cell development 3201
            hemopoiesis 1031
              leukocyte differentiation 665
                mononuclear cell differentiation 537
                  lymphocyte differentiation 434
                    B cell differentiation 147
                      mature B cell differentiation 46
                        B-1 B cell differentiation 7
                          B-1 B cell lineage commitment 1
                          B-1a B cell differentiation 4
                          B-1b B cell differentiation 0
                          negative regulation of B-1 B cell differentiation 0
                          positive regulation of B-1 B cell differentiation 0
                          regulation of B-1 B cell differentiation + 0
paths to the root