B-1 B cell homeostasis - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS	{{ watchLinkText }}

Term:	B-1 B cell homeostasis	go back to main search page
Accession:	GO:0001922	browse the term
Definition:	The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
Comment:	Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus.
Synonyms:	exact_synonym:	B-1 B lymphocyte homeostasis

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Genes (5)

B-1 B cell homeostasis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

acts_upstream_of_or_within

MGI:2153718 (MGI:3839222|PMID:19228876)

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

involved_in

(MGI:5464938|PMID:23169635)

NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715

G

hypoxia inducible factor 1 subunit alpha

involved_in
acts_upstream_of_or_within

GO_REF:0000107
(MGI:2159073|PMID:11854513)

GO_REF:0000107 MGI:2159073

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

SH2B adaptor protein 2

acts_upstream_of_or_within

MGI:2680256 (MGI:3033759|PMID:14993264)

NCBI chr12:20,427,057...20,456,845
Ensembl chr12:20,429,043...20,456,844

G

TNF alpha induced protein 3

involved_in

(MGI:4946158|PMID:21088135)

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

Term paths to the root

Path 1
Term	Annotations
biological_process	19574
immune system process	2665
leukocyte homeostasis	138
lymphocyte homeostasis	93
B cell homeostasis	43
B-1 B cell homeostasis	5
Path 2
Term	Annotations
biological_process	19574
multicellular organismal process	9171
multicellular organismal-level homeostasis	941
homeostasis of number of cells	401
leukocyte homeostasis	138
lymphocyte homeostasis	93
B cell homeostasis	43
B-1 B cell homeostasis	5

paths to the root