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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of T cell mediated cytotoxicity
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Accession:GO:0001916 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
Synonyms:exact_synonym: positive regulation of T cell mediated apoptosis;   positive regulation of T-cell mediated cell death;   positive regulation of T-cell mediated cell killing;   positive regulation of T-lymphocyte mediated cytotoxicity;   up regulation of T cell mediated cytotoxicity;   upregulation of T cell mediated cytotoxicity
 narrow_synonym: activation of T cell mediated cytotoxicity;   stimulation of T cell mediated cytotoxicity
 related_synonym: positive regulation of T-cell mediated cytolysis


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positive regulation of T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 2410137M14Rik RIKEN cDNA 2410137M14 gene involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:37,288,593...37,292,129
Ensembl chr17:37,288,593...37,292,129 		JBrowse link
G B2m beta-2 microglobulin acts_upstream_of_or_within IMP (PMID:16299293) MGI PMID:16299293 NCBI chr 2:121,978,168...121,983,563
Ensembl chr 2:121,978,167...121,983,564 		JBrowse link
G Cd1d1 CD1d1 antigen acts_upstream_of_or_within
involved_in		 IDA
IBA		 (PMID:10201995) MGI
GO_Central		 PMID:10201995 GO_REF:0000033 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748 		JBrowse link
G Cd1d2 CD1d2 antigen acts_upstream_of_or_within
involved_in		 IDA
IBA		 (PMID:10201995) MGI
GO_Central		 PMID:10201995 GO_REF:0000033 NCBI chr 3:86,893,875...86,896,843
Ensembl chr 3:86,893,858...86,897,087 		JBrowse link
G Cyrib CYFIP related Rac1 interactor B involved_in IDA (MGI:5432330|PMID:22522492) UniProt PMID:22522492 MGI:5432330 NCBI chr15:63,800,943...63,932,627
Ensembl chr15:63,800,946...63,932,327 		JBrowse link
G Fadd Fas associated via death domain involved_in IMP (MGI:5291865|PMID:21876153) UniProt PMID:21876153 MGI:5291865 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200 		JBrowse link
G Gm7030 predicted gene 7030 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,438,501...36,440,317
Ensembl chr17:36,420,611...36,440,317 		JBrowse link
G H2-Bl histocompatibility 2, blastocyst involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,391,002...36,395,141
Ensembl chr17:36,391,007...36,395,115 		JBrowse link
G H2-D1 histocompatibility 2, D region locus 1 acts_upstream_of_or_within
involved_in		 IDA
IBA		 (PMID:1538753) MGI
GO_Central		 PMID:1538753 GO_REF:0000033 NCBI chr17:35,482,070...35,486,473
Ensembl chr17:35,481,706...35,486,475 		JBrowse link
G H2-Ea histocompatibility 2, class II antigen E alpha involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:34,560,926...34,563,619
Ensembl chr17:34,560,926...34,563,618 		JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta involved_in ISO (PMID:29884618) UniProt PMID:29884618 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648 		JBrowse link
G H2-K1 histocompatibility 2, K1, K region involved_in
acts_upstream_of_or_within		 IBA
IDA		 (PMID:1538753), (PMID:16461341) GO_Central
MGI		 PMID:1538753 PMID:16461341 GO_REF:0000033 NCBI chr17:34,214,986...34,219,316
Ensembl chr17:34,214,991...34,219,321 		JBrowse link
G H2-L histocompatibility 2, D region locus L involved_in IBA GO_Central GO_REF:0000033
G H2-M1 histocompatibility 2, M region locus 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,979,922...36,983,089
Ensembl chr17:36,980,900...36,983,111 		JBrowse link
G H2-M10.1 histocompatibility 2, M region locus 10.1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,633,752...36,637,042
Ensembl chr17:36,633,750...36,637,047 		JBrowse link
G H2-M10.2 histocompatibility 2, M region locus 10.2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,595,173...36,597,313
Ensembl chr17:36,595,119...36,597,382 		JBrowse link
G H2-M10.3 histocompatibility 2, M region locus 10.3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,675,896...36,679,309
Ensembl chr17:36,675,895...36,679,309 		JBrowse link
G H2-M10.4 histocompatibility 2, M region locus 10.4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,769,809...36,773,221
Ensembl chr17:36,769,809...36,773,226 		JBrowse link
G H2-M10.5 histocompatibility 2, M region locus 10.5 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:37,083,802...37,087,127
Ensembl chr17:37,083,802...37,087,126 		JBrowse link
G H2-M10.6 histocompatibility 2, M region locus 10.6 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:37,123,067...37,126,458
Ensembl chr17:37,123,063...37,126,456 		JBrowse link
G H2-M11 histocompatibility 2, M region locus 11 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,857,967...36,861,165
Ensembl chr17:36,857,967...36,860,142 		JBrowse link
G H2-M2 histocompatibility 2, M region locus 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:37,791,742...37,794,445
Ensembl chr17:37,791,742...37,794,443 		JBrowse link
G H2-M3 histocompatibility 2, M region locus 3 involved_in
acts_upstream_of_or_within		 IBA
IDA
IMP		 (PMID:16299293), (PMID:16461341), (PMID:16476767), (PMID:8464890)
(PMID:16476767)		 GO_Central
MGI		 PMID:8464890 PMID:16299293 PMID:16461341 PMID:16476767 GO_REF:0000033 NCBI chr17:37,581,094...37,585,380
Ensembl chr17:37,581,111...37,585,375 		JBrowse link
G H2-M5 histocompatibility 2, M region locus 5 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:37,294,677...37,308,847
Ensembl chr17:37,294,953...37,300,429 		JBrowse link
G H2-M9 histocompatibility 2, M region locus 9 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,950,169...36,953,598
Ensembl chr17:36,950,177...36,953,558 		JBrowse link
G H2-Q1 histocompatibility 2, Q region locus 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075 		JBrowse link
G H2-Q10 histocompatibility 2, Q region locus 10 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:35,780,986...35,785,460
Ensembl chr17:35,780,986...35,785,460 		JBrowse link
G H2-Q2 histocompatibility 2, Q region locus 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:35,561,283...35,565,740
Ensembl chr17:35,561,218...35,565,738 		JBrowse link
G H2-Q4 histocompatibility 2, Q region locus 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:35,598,593...35,603,650
Ensembl chr17:35,598,593...35,604,266 		JBrowse link
G H2-Q6 histocompatibility 2, Q region locus 6 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:35,643,826...35,649,031
Ensembl chr17:35,643,826...35,649,031 		JBrowse link
G H2-Q7 histocompatibility 2, Q region locus 7 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:35,658,131...35,662,749
Ensembl chr17:35,658,131...35,662,749 		JBrowse link
G H2-Q8 histocompatibility 2, Q region locus 8 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:35,737,710...35,742,945 JBrowse link
G H2-Q9 histocompatibility 2, Q region locus 9 involved_in
acts_upstream_of_or_within		 IBA
IDA		 (PMID:18541714) GO_Central
MGI		 PMID:18541714 GO_REF:0000033 NCBI chr17:35,752,074...35,756,659 JBrowse link
G H2-T10 histocompatibility 2, T region locus 10 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,426,763...36,432,336
Ensembl chr17:36,426,768...36,432,357 		JBrowse link
G H2-T22 histocompatibility 2, T region locus 22 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,348,023...36,353,635
Ensembl chr17:36,348,020...36,353,639 		JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 acts_upstream_of_or_within
involved_in		 IDA
IBA		 (PMID:1538753) MGI
GO_Central		 PMID:1538753 GO_REF:0000033 NCBI chr17:36,340,869...36,343,593
Ensembl chr17:36,340,665...36,343,747 		JBrowse link
G H2-T24 histocompatibility 2, T region locus 24 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,314,363...36,331,689
Ensembl chr17:36,316,587...36,331,452 		JBrowse link
G H2-T26 histocompatibility 2, T region locus 26 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,454,704...36,479,490
Ensembl chr17:36,475,335...36,479,429 		JBrowse link
G H2-T27 histocompatibility 2, T region locus 27 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,366,708...36,369,346
Ensembl chr17:36,366,708...36,369,263 		JBrowse link
G H2-T3 histocompatibility 2, T region locus 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:36,496,463...36,501,043
Ensembl chr17:36,496,464...36,501,179 		JBrowse link
G H60b histocompatibility 60b involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:22,149,373...22,164,748
Ensembl chr10:22,034,485...22,164,748 		JBrowse link
G H60c histocompatibility 60c involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:3,206,202...3,218,091
Ensembl chr10:3,206,208...3,217,771 		JBrowse link
G Hfe homeostatic iron regulator involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837 		JBrowse link
G Hspa1b heat shock protein 1B ISO prevention of heat shock-induced resistance to CTL-mediated killing RGD PMID:10679071 RGD:1298959 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Hspa8 heat shock protein 8 ISO RGD PMID:8871636 RGD:10059395 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383 		JBrowse link
G Il12a interleukin 12a involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880 		JBrowse link
G Il12b interleukin 12b involved_in IDA (MGI:3027369|PMID:14688363) BHF-UCL PMID:14688363 MGI:3027369 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il23a interleukin 23, alpha subunit p19 involved_in IDA (MGI:3027369|PMID:14688363) BHF-UCL PMID:14688363 MGI:3027369 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621 		JBrowse link
G Mill1 MHC I like leukocyte 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:17,979,150...18,000,017
Ensembl chr 7:17,979,272...18,000,017 		JBrowse link
G Mill2 MHC I like leukocyte 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:18,573,878...18,603,621
Ensembl chr 7:18,573,891...18,599,327 		JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 acts_upstream_of_or_within IMP (PMID:14761980) MGI PMID:14761980 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495 		JBrowse link
G Pnp purine-nucleoside phosphorylase acts_upstream_of_or_within IMP (PMID:10859343) MGI PMID:10859343 NCBI chr14:51,181,760...51,190,869
Ensembl chr14:51,168,539...51,190,869 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C acts_upstream_of_or_within IMP (PMID:6233370) MGI PMID:6233370 NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446 		JBrowse link
G Raet1a retinoic acid early transcript 1, alpha involved_in IBA GO_Central GO_REF:0000033
G Raet1b retinoic acid early transcript beta involved_in IBA GO_Central GO_REF:0000033
G Raet1c retinoic acid early transcript gamma involved_in IBA GO_Central GO_REF:0000033
G Raet1d retinoic acid early transcript delta involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:22,181,145...22,250,042
Ensembl chr10:22,236,451...22,250,038 		JBrowse link
G Raet1e retinoic acid early transcript 1E involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:22,034,441...22,059,820
Ensembl chr10:22,034,468...22,250,038 		JBrowse link
G Stx7 syntaxin 7 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:24,025,182...24,064,859
Ensembl chr10:24,025,200...24,066,120 		JBrowse link
G Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) acts_upstream_of_or_within IMP
IDA
ISO		 (PMID:16299293)
(PMID:1538753)		 MGI PMID:1538753 PMID:16299293 GO_REF:0000008 NCBI chr17:34,423,453...34,435,295
Ensembl chr17:34,422,501...34,435,295 		JBrowse link
G Ulbp1 UL16 binding protein 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:7,394,873...7,423,643
Ensembl chr10:7,390,362...7,423,638 		JBrowse link
G Xcl1 chemokine (C motif) ligand 1 involved_in ISO (PMID:18832695) BHF-UCL PMID:18832695 NCBI chr 1:164,759,216...164,763,094
Ensembl chr 1:164,759,213...164,763,096 		JBrowse link
positive regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mr1 major histocompatibility complex, class I-related involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:155,003,620...155,022,560
Ensembl chr 1:155,003,023...155,022,560 		JBrowse link
G Slc22a13 solute carrier family 22 (organic cation transporter), member 13 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:119,020,618...119,038,171
Ensembl chr 9:119,022,040...119,038,164 		JBrowse link
susceptibility to T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:19,450,569...19,483,498
Ensembl chr 7:19,450,569...19,484,408 		JBrowse link
G Pvr poliovirus receptor involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:19,637,503...19,655,068
Ensembl chr 7:19,637,503...19,655,085 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    cellular process 17545
      cell killing 311
        leukocyte mediated cytotoxicity 191
          positive regulation of leukocyte mediated cytotoxicity 106
            positive regulation of T cell mediated cytotoxicity 66
              positive regulation of T cell mediated cytotoxicity directed against tumor cell target 2
              positive regulation of cytotoxic T cell degranulation 0
              susceptibility to T cell mediated cytotoxicity 2
Path 2
Term Annotations click to browse term
  biological_process 28573
    biological regulation 13118
      regulation of biological process 12727
        regulation of immune system process 1786
          regulation of immune effector process 493
            regulation of leukocyte mediated immunity 321
              regulation of lymphocyte mediated immunity 249
                regulation of T cell mediated immunity 131
                  regulation of T cell mediated cytotoxicity 75
                    positive regulation of T cell mediated cytotoxicity 66
                      positive regulation of T cell mediated cytotoxicity directed against tumor cell target 2
                      positive regulation of cytotoxic T cell degranulation 0
                      susceptibility to T cell mediated cytotoxicity 2
paths to the root