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ONTOLOGY REPORT - ANNOTATIONS


Term:activation of membrane attack complex
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Accession:GO:0001905 term browser browse the term
Definition:The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.
Synonyms:exact_synonym: MAC assembly;   MAC formation;   activation of MAC;   membrane attack complex assembly;   membrane attack complex formation
 narrow_synonym: activation of TCC;   activation of terminal complement complex;   activation of the terminal complement cascade


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negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59 CD59 molecule (CD59 blood group) involved_in
acts_upstream_of_or_within
ISO
IEA
(MGI:1888643|PMID:10946279), (MGI:2148385|PMID:11471050) RGD
InterPro
MGI
PMID:10946279 PMID:11471050 PMID:15843577 GO_REF:0000002 MGI:1888643 MGI:2148385 RGD:1600482 NCBI chrNW_004936533:4,242,589...4,263,136 JBrowse link
G LOC101964865 complement receptor type 1 acts_upstream_of ISO (PMID:31862673) ARUK-UCL PMID:31862673 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in ISO (MGI:4430818|PMID:15611275) BHF-UCL PMID:15611275 MGI:4430818 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G C6 complement C6 involved_in ISO (MGI:4430818|PMID:15611275) BHF-UCL PMID:15611275 MGI:4430818 NCBI chrNW_004936518:1,471,116...1,532,733 JBrowse link
G LOC101964865 complement receptor type 1 involved_in ISO (PMID:11981823) ARUK-UCL PMID:11981823 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14953
    immune system process 2126
      immune effector process 514
        complement activation 44
          activation of membrane attack complex 4
            negative regulation of activation of membrane attack complex 2
            positive regulation of activation of membrane attack complex 3
            regulation of activation of membrane attack complex + 4
Path 2
Term Annotations click to browse term
  biological_process 14953
    biological regulation 10655
      regulation of biological process 10116
        positive regulation of biological process 5765
          positive regulation of response to stimulus 2001
            positive regulation of immune response 441
              activation of immune response 237
                complement activation 44
                  activation of membrane attack complex 4
                    negative regulation of activation of membrane attack complex 2
                    positive regulation of activation of membrane attack complex 3
                    regulation of activation of membrane attack complex + 4
paths to the root