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ONTOLOGY REPORT - ANNOTATIONS


Term:activation of membrane attack complex
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Accession:GO:0001905 term browser browse the term
Definition:The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.
Synonyms:exact_synonym: MAC assembly;   MAC formation;   activation of MAC;   membrane attack complex assembly;   membrane attack complex formation
 narrow_synonym: activation of TCC;   activation of terminal complement complex;   activation of the terminal complement cascade



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activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFH complement factor H acts_upstream_of_or_within ISO (MGI:4837299|PMID:20813971) MGI PMID:20813971 MGI:4837299
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD59 CD59 molecule involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:1888643|PMID:10946279), (MGI:2148385|PMID:11471050)
GO_Central
InterPro
GO_Central
MGI
RGD
PMID:10946279 PMID:11471050 PMID:15843577 PMID:21873635 GO_REF:0000002 MGI:1888643 MGI:2148385 RGD:1600482 NCBI chr 2:27,186,587...27,207,303 JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) acts_upstream_of ISO (PMID:31862673) ARUK-UCL PMID:31862673 NCBI chr 9:68,025,673...68,132,162 JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,499...72,528,112
JBrowse link
G C6 complement C6 involved_in ISO (MGI:4430818|PMID:15611275) BHF-UCL PMID:15611275 MGI:4430818 NCBI chr16:26,023,646...26,089,518
Ensembl chr16:26,023,684...26,084,652
JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in ISO (PMID:11981823) ARUK-UCL PMID:11981823 NCBI chr 9:68,025,673...68,132,162 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16975
    immune system process 2392
      immune effector process 604
        complement activation 56
          activation of membrane attack complex 5
            negative regulation of activation of membrane attack complex 2
            positive regulation of activation of membrane attack complex 3
            regulation of activation of membrane attack complex + 4
Path 2
Term Annotations click to browse term
  biological_process 16975
    biological regulation 12437
      regulation of biological process 11807
        positive regulation of biological process 6338
          positive regulation of response to stimulus 2170
            positive regulation of immune response 493
              activation of immune response 278
                complement activation 56
                  activation of membrane attack complex 5
                    negative regulation of activation of membrane attack complex 2
                    positive regulation of activation of membrane attack complex 3
                    regulation of activation of membrane attack complex + 4
paths to the root