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ONTOLOGY REPORT - ANNOTATIONS


Term:activation of membrane attack complex
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Accession:GO:0001905 term browser browse the term
Definition:The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.
Synonyms:exact_synonym: MAC assembly;   MAC formation;   activation of MAC;   membrane attack complex assembly;   membrane attack complex formation
 narrow_synonym: activation of TCC;   activation of terminal complement complex;   activation of the terminal complement cascade



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activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement component factor h acts_upstream_of_or_within IMP (MGI:4837299|PMID:20813971) MGI PMID:20813971 MGI:4837299 NCBI chr 1:140,085,855...140,183,411
Ensembl chr 1:140,084,708...140,183,764
JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59a CD59a antigen involved_in
acts_upstream_of_or_within
IBA
ISO
IDA
IMP
(MGI:6201960|PMID:21873635)
(MGI:2148385|PMID:11471050)
(MGI:3828358|PMID:17237428)
GO_Central
MGI
BHF-UCL
PMID:11471050 PMID:17237428 PMID:21873635 GO_REF:0000096 MGI:2148385 MGI:3828358 MGI:4417868 MGI:6201960 NCBI chr 2:104,095,753...104,115,410
Ensembl chr 2:104,095,801...104,115,354
JBrowse link
G Cd59b CD59b antigen acts_upstream_of_or_within
involved_in
IDA
IBA
ISO
(MGI:1888643|PMID:10946279), (MGI:2148385|PMID:11471050)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
RGD
PMID:10946279 PMID:11471050 PMID:15843577 PMID:21873635 GO_REF:0000096 MGI:1888643 MGI:2148385 MGI:4417868 MGI:6201960 RGD:1600482 NCBI chr 2:104,069,781...104,085,790
Ensembl chr 2:104,069,849...104,091,187
JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement component 3 involved_in IMP (MGI:4430818|PMID:15611275) BHF-UCL PMID:15611275 MGI:4430818 NCBI chr17:57,203,967...57,228,136
Ensembl chr17:57,203,970...57,228,136
JBrowse link
G C6 complement component 6 involved_in IMP (MGI:4430818|PMID:15611275) BHF-UCL PMID:15611275 MGI:4430818 NCBI chr15:4,727,067...4,804,045
Ensembl chr15:4,727,175...4,814,967
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28615
    immune system process 3033
      immune effector process 827
        complement activation 188
          activation of membrane attack complex 5
            negative regulation of activation of membrane attack complex 2
            positive regulation of activation of membrane attack complex 2
            regulation of activation of membrane attack complex + 4
Path 2
Term Annotations click to browse term
  biological_process 28615
    biological regulation 13376
      regulation of biological process 12719
        positive regulation of biological process 6809
          positive regulation of response to stimulus 2445
            positive regulation of immune response 716
              activation of immune response 454
                complement activation 188
                  activation of membrane attack complex 5
                    negative regulation of activation of membrane attack complex 2
                    positive regulation of activation of membrane attack complex 2
                    regulation of activation of membrane attack complex + 4
paths to the root