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ONTOLOGY REPORT - ANNOTATIONS


Term:activation of membrane attack complex
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Accession:GO:0001905 term browser browse the term
Definition:The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.
Synonyms:exact_synonym: MAC assembly;   MAC formation;   activation of MAC;   membrane attack complex assembly;   membrane attack complex formation
 narrow_synonym: activation of TCC;   activation of terminal complement complex;   activation of the terminal complement cascade



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activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFH complement factor H acts_upstream_of_or_within ISO (MGI:4837299|PMID:20813971) MGI PMID:20813971 MGI:4837299 NCBI chr 1:196,652,033...196,747,504
Ensembl chr 1:196,652,043...196,747,504
JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AL049629.2 novel protein involved_in IEA InterPro
InterPro
GO_REF:0000002 Ensembl chr11:33,698,261...33,722,467 JBrowse link
G CD59 CD59 molecule (CD59 blood group) involved_in
acts_upstream_of_or_within
IEA
IBA
ISO
(PMID:21873635)
(MGI:1888643|PMID:10946279), (MGI:2148385|PMID:11471050)
InterPro
GO_Central
InterPro
MGI
RGD
GO_Central
PMID:10946279 PMID:11471050 PMID:15843577 PMID:21873635 GO_REF:0000002 MGI:1888643 MGI:2148385 RGD:1600482 NCBI chr11:33,703,010...33,736,479
Ensembl chr11:33,703,010...33,736,479
JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) acts_upstream_of IDA (PMID:31862673) ARUK-UCL
ARUK-UCL
PMID:31862673 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765
JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
JBrowse link
G C6 complement C6 involved_in ISO (MGI:4430818|PMID:15611275) BHF-UCL PMID:15611275 MGI:4430818 NCBI chr 5:41,142,116...41,261,486
Ensembl chr 5:41,142,116...41,261,438
JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in IMP (PMID:11981823) ARUK-UCL
ARUK-UCL
PMID:11981823 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18661
    immune system process 3127
      immune effector process 746
        complement activation 147
          activation of membrane attack complex 6
            negative regulation of activation of membrane attack complex 3
            positive regulation of activation of membrane attack complex 3
            regulation of activation of membrane attack complex + 5
Path 2
Term Annotations click to browse term
  biological_process 18661
    biological regulation 13218
      regulation of biological process 12506
        positive regulation of biological process 6904
          positive regulation of response to stimulus 2418
            positive regulation of immune response 673
              activation of immune response 442
                complement activation 147
                  activation of membrane attack complex 6
                    negative regulation of activation of membrane attack complex 3
                    positive regulation of activation of membrane attack complex 3
                    regulation of activation of membrane attack complex + 5
paths to the root