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ONTOLOGY REPORT - ANNOTATIONS


Term:NK T cell differentiation
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Accession:GO:0001865 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of a NK T cell.
Comment:Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: NK T lymphocyte differentiation;   NKT cell differentiation;   NT cell differentiation;   natural T cell differentiation;   natural killer T cell differentiation
 related_synonym: NK T cell development



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NK T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF2 activating transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:62,348,245...62,444,428
Ensembl chr2B:179,799,365...179,895,007
JBrowse link
G CD1D CD1d molecule involved_in ISO (MGI:87097|PMID:9133426) CACAO PMID:9133426 MGI:87097 NCBI chr 1:133,549,258...133,557,752
Ensembl chr 1:137,341,690...137,348,173
JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4354430|PMID:19620306) MGI
Ensembl
PMID:19620306 GO_REF:0000107 MGI:4354430 NCBI chr2A:28,392,328...28,416,838
Ensembl chr2A:28,485,613...28,498,397
JBrowse link
G ITK IL2 inducible T cell kinase acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3773943|PMID:18292523) MGI
TreeGrafter
Ensembl
PMID:18292523 GO_REF:0000107 GO_REF:0000118 MGI:3773943 NCBI chr 5:152,582,125...152,656,211
Ensembl chr 5:159,204,016...159,277,689
JBrowse link
G PSAP prosaposin acts_upstream_of_or_within ISO (MGI:3043877|PMID:14684827) MGI PMID:14684827 MGI:3043877 NCBI chr10:68,286,359...68,321,349
Ensembl chr10:70,810,881...70,828,781
JBrowse link
G STK17A serine/threonine kinase 17a involved_in ISO (MGI:5694641|PMID:26423156) MGI PMID:26423156 MGI:5694641 NCBI chr 7:40,625,069...40,668,016 JBrowse link
G TXK TXK tyrosine kinase acts_upstream_of_or_within ISO (MGI:3773943|PMID:18292523) MGI PMID:18292523 MGI:3773943 NCBI chr 4:74,039,292...74,086,744
Ensembl chr 4:84,750,804...84,818,671
JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:130,350,798...130,366,690
Ensembl chr 1:133,959,847...133,975,729
JBrowse link
G ZNF683 zinc finger protein 683 acts_upstream_of_or_within ISO (MGI:5437828|PMID:22885984) MGI PMID:22885984 MGI:5437828 NCBI chr 1:25,622,548...25,636,106
Ensembl chr 1:26,690,359...26,703,755
JBrowse link
NK T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TOX thymocyte selection associated high mobility group box involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:55,246,933...55,553,839
Ensembl chr 8:56,922,773...57,219,410
JBrowse link
positive regulation of NK T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP3B1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2679144|PMID:14557411) MGI
Ensembl
PMID:14557411 GO_REF:0000107 MGI:2679144 NCBI chr 5:37,015,518...37,305,769
Ensembl chr 5:37,503,162...37,840,205
JBrowse link
G AP3D1 adaptor related protein complex 3 subunit delta 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2679144|PMID:14557411) MGI
Ensembl
PMID:14557411 GO_REF:0000107 MGI:2679144 NCBI chr19:1,110,419...1,161,826
Ensembl chr19:2,085,540...2,137,593
JBrowse link
G CD1D CD1d molecule acts_upstream_of_or_within ISO (MGI:87097|PMID:9133426)
(MGI:2180705|PMID:10201995)
MGI PMID:9133426 PMID:10201995 MGI:2180705 MGI:87097 NCBI chr 1:133,549,258...133,557,752
Ensembl chr 1:137,341,690...137,348,173
JBrowse link
G IKZF1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO (MGI:1340364|PMID:10366784) MGI PMID:10366784 MGI:1340364 NCBI chr 7:50,946,817...51,047,168
Ensembl chr 7:51,191,685...51,291,245
JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3686949|PMID:16973387) MGI
Ensembl
PMID:16973387 GO_REF:0000107 MGI:3686949 NCBI chr 3:30,536,187...30,623,653
Ensembl chr 3:30,854,460...30,938,856
JBrowse link
G ZBTB16 zinc finger and BTB domain containing 16 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:108,938,414...109,133,819
Ensembl chr11:112,780,380...112,977,164
JBrowse link
regulation of NK T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRDM1 PR/SET domain 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:103,899,410...103,923,389
Ensembl chr 6:107,773,229...107,796,815
JBrowse link
G ZNF683 zinc finger protein 683 involved_in ISO (MGI:5779429|PMID:27102484) UniProt PMID:27102484 MGI:5779429 NCBI chr 1:25,622,548...25,636,106
Ensembl chr 1:26,690,359...26,703,755
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16309
    immune system process 2386
      leukocyte activation 973
        lymphocyte activation 789
          T cell activation 554
            T cell differentiation 314
              alpha-beta T cell differentiation 136
                NK T cell differentiation 16
                  NK T cell lineage commitment 1
                  negative regulation of NK T cell differentiation 0
                  positive regulation of NK T cell differentiation 6
                  regulation of NK T cell differentiation + 8
Path 2
Term Annotations click to browse term
  biological_process 16309
    cellular process 15385
      cellular developmental process 4391
        cell differentiation 4390
          cell development 3127
            hemopoiesis 995
              leukocyte differentiation 636
                mononuclear cell differentiation 478
                  lymphocyte differentiation 420
                    T cell differentiation 314
                      alpha-beta T cell differentiation 136
                        NK T cell differentiation 16
                          NK T cell lineage commitment 1
                          negative regulation of NK T cell differentiation 0
                          positive regulation of NK T cell differentiation 6
                          regulation of NK T cell differentiation + 8
paths to the root