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ONTOLOGY REPORT - ANNOTATIONS


Term:protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
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Accession:GO:0001844 term browser browse the term
Definition:The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway.
Comment:Note that this term is intended to cover the insertion of pro-apoptotic proteins such as Bax or its homologs into mitochondrial membranes which occurs as an early step in the apoptotic program.
Synonyms:narrow_synonym: insertion of proteins into mitochondrial membranes during the induction of apoptosis;   protein insertion into mitochondrial membrane involved in induction of apoptosis;   protein insertion into mitochondrion membrane during induction of apoptosis
 related_synonym: protein insertion into mitochondrial membrane during induction of apoptosis


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protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857429 (MGI:2675761|PMID:12952892)
Ensembl
RGD
PMID:12952892 GO_REF:0000107 MGI:2675761 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Moap1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:121,882,565...121,884,500 JBrowse link
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 Bcl-2 binding component 3 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:17024184)
MGI:2681654 (MGI:3804133|PMID:16705087)
RGD PMID:16705087 PMID:17024184, PMID:21873635 MGI:3804133, RGD:13792537 NCBI chr 1:77,013,281...77,022,509 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within ISO MGI:2678372 (MGI:2675761|PMID:12952892) RGD PMID:12952892 MGI:2675761 NCBI chr18:59,986,187...59,990,174 JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 acts_upstream_of_or_within ISO (MGI:3607027|PMID:16227588) RGD PMID:16227588 MGI:3607027 NCBI chr 2:233,750,838...233,784,817 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    signaling 7457
      signal transduction 6880
        apoptotic signaling pathway 622
          mitochondrial outer membrane permeabilization 33
            protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 5
              positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3
              regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 19492
    cellular process 18342
      cellular component organization or biogenesis 6723
        cellular component organization 6483
          organelle organization 4060
            mitochondrion organization 549
              mitochondrial membrane organization 109
                regulation of mitochondrial membrane permeability 59
                  positive regulation of mitochondrial membrane permeability 41
                    mitochondrial outer membrane permeabilization involved in programmed cell death 38
                      positive regulation of mitochondrial membrane permeability involved in apoptotic process 36
                        mitochondrial outer membrane permeabilization 33
                          protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 5
                            positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3
                            regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway + 3
paths to the root