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ONTOLOGY REPORT - ANNOTATIONS


Term:protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
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Accession:GO:0001844 term browser browse the term
Definition:The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway.
Comment:Note that this term is intended to cover the insertion of pro-apoptotic proteins such as Bax or its homologs into mitochondrial membranes which occurs as an early step in the apoptotic program.
Synonyms:narrow_synonym: insertion of proteins into mitochondrial membranes during the induction of apoptosis;   protein insertion into mitochondrial membrane involved in induction of apoptosis;   protein insertion into mitochondrion membrane during induction of apoptosis
 related_synonym: protein insertion into mitochondrial membrane during induction of apoptosis



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protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO MGI:1857429 (MGI:2675761|PMID:12952892) RGD PMID:12952892 MGI:2675761 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 acts_upstream_of ISO MGI:2681654 (MGI:3804133|PMID:16705087) RGD PMID:16705087 MGI:3804133 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Moap1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:121,882,565...121,884,500
Ensembl chr 6:121,882,366...121,898,643
JBrowse link
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 Bcl-2 binding component 3 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:17024184)
MGI:2681654 (MGI:3804133|PMID:16705087)
RGD PMID:16705087 PMID:17024184 PMID:21873635 MGI:3804133, RGD:13792537 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within ISO MGI:2678372 (MGI:2675761|PMID:12952892) RGD PMID:12952892 MGI:2675761 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 acts_upstream_of_or_within ISO (MGI:3607027|PMID:16227588) RGD PMID:16227588 MGI:3607027 NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    signaling 7708
      signal transduction 7133
        apoptotic signaling pathway 637
          mitochondrial outer membrane permeabilization 37
            protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 5
              positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3
              regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 20091
    cellular process 18675
      cellular component organization or biogenesis 6788
        cellular component organization 6542
          organelle organization 3671
            mitochondrion organization 595
              mitochondrial membrane organization 113
                regulation of mitochondrial membrane permeability 62
                  positive regulation of mitochondrial membrane permeability 48
                    mitochondrial outer membrane permeabilization involved in programmed cell death 45
                      positive regulation of mitochondrial membrane permeability involved in apoptotic process 43
                        mitochondrial outer membrane permeabilization 37
                          protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 5
                            positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3
                            regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway + 3
paths to the root