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ONTOLOGY REPORT - ANNOTATIONS

Term:B cell homeostasis
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Accession:GO:0001782 term browser browse the term
Definition:The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Comment:Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus.
Synonyms:exact_synonym: B lymphocyte homeostasis


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B cell homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor involved_in ISO (MGI:72762|PMID:7732381) RGD PMID:7732381 MGI:72762 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 acts_upstream_of_or_within ISO MGI:1197519|MGI:2159364 (MGI:3581932|PMID:15967824), (MGI:3588597|PMID:16055554) RGD PMID:15967824 PMID:16055554 MGI:3581932 MGI:3588597 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO MGI:1197519|MGI:1857429 (MGI:3581932|PMID:15967824), (MGI:3588597|PMID:16055554) RGD PMID:15967824 PMID:16055554 MGI:3581932 MGI:3588597 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:1857134|MGI:2156165 (MGI:2154874|PMID:11709185), (MGI:2156164|PMID:8170972), (MGI:2385423|PMID:7650488)
GO_REF:0000107		 RGD
Ensembl		 PMID:7650488 PMID:8170972 PMID:11709185 GO_REF:0000107 MGI:2154874 MGI:2156164 MGI:2385423 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l11 Bcl2-like 11 acts_upstream_of_or_within ISO MGI:1097161|MGI:2156498|MGI:3589204|MGI:99702 (MGI:3581932|PMID:15967824), (MGI:3588597|PMID:16055554), (MGI:3610512|PMID:16270031) RGD PMID:15967824 PMID:16055554 PMID:16270031 MGI:3581932 MGI:3588597 MGI:3610512 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Camlg calcium modulating ligand involved_in ISS
ISO		 GO_REF:0000024
(MGI:5317494|PMID:22351938)		 UniProt
RGD		 PMID:22351938 GO_REF:0000024 MGI:5317494 NCBI chr17:8,992,697...9,003,576
Ensembl chr17:8,992,696...9,003,552 		JBrowse link
G Casp3 caspase 3 acts_upstream_of_or_within ISO MGI:2178778 (MGI:2677082|PMID:12970760) RGD PMID:12970760 MGI:2677082 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Dock10 dedicator of cytokinesis 10 involved_in ISO (MGI:5810214|PMID:27502165), (MGI:5818419|PMID:25729399) RGD PMID:25729399 PMID:27502165 MGI:5810214 MGI:5818419 NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525 		JBrowse link
G Dock11 dedicator of cytokinesis 11 involved_in ISO (MGI:5818419|PMID:25729399) RGD PMID:25729399 MGI:5818419 NCBI chr  X:115,131,720...115,314,854
Ensembl chr  X:115,131,909...115,314,854 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:1857034 (MGI:1331533|PMID:10072494) RGD PMID:10072494 MGI:1331533 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gapt Grb2-binding adaptor protein, transmembrane acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:3809581 (MGI:3804359|PMID:18559951)
PMID:21873635		 RGD PMID:18559951 PMID:21873635 MGI:3804359, RGD:13792537 NCBI chr 2:41,927,533...41,932,120
Ensembl chr 2:41,927,532...41,932,093 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta acts_upstream_of_or_within ISO MGI:2678815 (MGI:2387265|PMID:12235208) RGD PMID:12235208 MGI:2387265 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma acts_upstream_of_or_within ISO MGI:2679024 (MGI:2387265|PMID:12235208) RGD PMID:12235208 MGI:2387265 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il7r interleukin 7 receptor acts_upstream_of_or_within ISO MGI:98936|MGI:98937 (MGI:3581459|PMID:15909309) RGD PMID:15909309 MGI:3581459 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISS
ISO		 GO_REF:0000024
(MGI:894972|PMID:9252121)		 UniProt
RGD		 PMID:9252121 GO_REF:0000024 MGI:894972 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO		 GO_REF:0000024
(MGI:3844189|PMID:19211936)		 UniProt
RGD		 PMID:19211936 GO_REF:0000024 MGI:3844189 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO		 GO_REF:0000024
(MGI:3818191|PMID:19015308)		 UniProt
RGD		 PMID:19015308 GO_REF:0000024 MGI:3818191 NCBI chr 7:134,577,470...134,622,928
Ensembl chr 7:134,577,482...134,622,934 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta acts_upstream_of_or_within ISO MGI:2388047 (MGI:2387266|PMID:12235209) RGD PMID:12235209 MGI:2387266 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pirb paired Ig-like receptor B acts_upstream_of_or_within ISO MGI:2180757 (MGI:2180258|PMID:12021780) RGD PMID:12021780 MGI:2180258 NCBI chr 1:65,499,195...65,506,666
Ensembl chr 1:65,499,195...65,506,666 		JBrowse link
G Pkn1 protein kinase N1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:5475202 (MGI:5467878|PMID:23223530)
GO_REF:0000107		 RGD
Ensembl		 PMID:23223530 GO_REF:0000107 MGI:5467878 NCBI chr19:24,442,130...24,470,107
Ensembl chr19:24,442,122...24,470,107 		JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 PMID:21873635
GO_REF:0000107
MGI:3759678 (MGI:3589325|PMID:16129705)		 Ensembl
RGD		 PMID:16129705 PMID:21873635 GO_REF:0000107 MGI:3589325, RGD:13792537 NCBI chr 6:72,647,025...72,670,885
Ensembl chr 6:72,647,025...72,672,491 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO MGI:2442789 (MGI:5486592|PMID:23583643) RGD PMID:23583643 MGI:5486592 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within ISO MGI:2685397 (MGI:5486592|PMID:23583643) RGD PMID:23583643 MGI:5486592 NCBI chr 3:21,121,531...21,186,711
Ensembl chr 3:21,110,679...21,179,933 		JBrowse link
G Sash3 SAM and SH3 domain containing 3 acts_upstream_of_or_within ISO MGI:3716944 (MGI:3607020|PMID:16227612) RGD PMID:16227612 MGI:3607020 NCBI chr  X:127,326,815...127,341,521
Ensembl chr  X:127,326,859...127,341,519 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:98355 (MGI:5547878|PMID:24043312) RGD PMID:24043312 MGI:5547878 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 acts_upstream_of_or_within ISO MGI:98354 (MGI:5547878|PMID:24043312) RGD PMID:24043312 MGI:5547878 NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692 		JBrowse link
G Spns2 SPNS lysolipid transporter 2, sphingosine-1-phosphate acts_upstream_of_or_within ISO MGI:4460276|MGI:5426392|MGI:5442804 (MGI:5424314|PMID:22406534), (MGI:5442641|PMID:22664872) RGD PMID:22406534 PMID:22664872 MGI:5424314 MGI:5442641 NCBI chr10:57,067,348...57,105,969
Ensembl chr10:57,066,897...57,105,957 		JBrowse link
G Tnfrsf13b TNF receptor superfamily member 13B acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:3052983 (MGI:3051152|PMID:15240667), (MGI:3721843|PMID:14707116)
PMID:21873635		 RGD PMID:14707116 PMID:15240667 PMID:21873635 MGI:3051152 MGI:3721843, RGD:13792537 NCBI chr10:45,801,860...45,824,932
Ensembl chr10:45,801,860...45,822,987 		JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C acts_upstream_of_or_within ISO MGI:2389403 (MGI:3036943|PMID:14557413) RGD PMID:14557413 MGI:3036943 NCBI chr 7:113,736,046...113,738,523
Ensembl chr 7:113,736,055...113,738,517 		JBrowse link
G Tnfsf13b TNF superfamily member 13b acts_upstream_of_or_within ISO MGI:2387426 (MGI:3036943|PMID:14557413) RGD PMID:14557413 MGI:3036943 NCBI chr16:79,462,406...79,492,888
Ensembl chr16:79,462,402...79,492,693 		JBrowse link
G Traf3ip2 Traf3 interacting protein 2 involved_in ISO MGI:3510784 (MGI:4460017|PMID:20543113) RGD PMID:20543113 MGI:4460017 NCBI chr20:43,011,405...43,054,654
Ensembl chr20:43,011,450...43,054,667 		JBrowse link
G Vpreb1a V-set pre-B cell surrogate light chain 1A acts_upstream_of_or_within ISO MGI:96562|MGI:98937 (MGI:3581459|PMID:15909309) RGD PMID:15909309 MGI:3581459 NCBI chr11:84,126,969...84,127,846
Ensembl chr11:84,126,969...84,127,846 		JBrowse link
G Vpreb1b V-set pre-B cell surrogate light chain 1B acts_upstream_of_or_within ISO MGI:96562|MGI:98936 (MGI:3581459|PMID:15909309) RGD PMID:15909309 MGI:3581459 NCBI chr11:83,009,396...83,010,106
Ensembl chr11:83,009,396...83,010,106 		JBrowse link
B-1 B cell homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:2153718 (MGI:3839222|PMID:19228876) RGD PMID:19228876 MGI:3839222 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO (MGI:5464938|PMID:23169635) RGD PMID:23169635 MGI:5464938 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:2159073|PMID:11854513)		 Ensembl
RGD		 PMID:11854513 GO_REF:0000107 MGI:2159073 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Sh2b2 SH2B adaptor protein 2 acts_upstream_of_or_within ISO MGI:2680256 (MGI:3033759|PMID:14993264) RGD PMID:14993264 MGI:3033759 NCBI chr12:20,427,057...20,456,845
Ensembl chr12:20,429,043...20,456,844 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (MGI:4946158|PMID:21088135) RGD PMID:21088135 MGI:4946158 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
mature B cell apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of
involved_in		 ISO
IEA		 MGI:1857117|MGI:2683027 (MGI:3619310|PMID:14607964)
GO_REF:0000107		 RGD
Ensembl		 PMID:14607964 GO_REF:0000107 MGI:3619310 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
negative regulation of mature B cell apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:1857117|MGI:2683027 (MGI:3619310|PMID:14607964)
GO_REF:0000107		 RGD
Ensembl		 PMID:14607964 GO_REF:0000107 MGI:3619310 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Bcl10 BCL10, immune signaling adaptor involved_in ISO
ISS		 (PMID:15878976)
GO_REF:0000024		 RGD
UniProt		 PMID:15878976 GO_REF:0000024 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) involved_in ISO (MGI:3773489|PMID:18056708) RGD PMID:18056708 MGI:3773489 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd74 CD74 molecule involved_in ISS
ISO		 GO_REF:0000024
(MGI:3773489|PMID:18056708)		 BHF-UCL
RGD		 PMID:18056708 GO_REF:0000024 MGI:3773489 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (MGI:3773489|PMID:18056708) RGD PMID:18056708 MGI:3773489 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19572
    immune system process 2665
      leukocyte homeostasis 138
        lymphocyte homeostasis 93
          B cell homeostasis 43
            B-1 B cell homeostasis 5
            mature B cell apoptotic process + 5
Path 2
Term Annotations click to browse term
  biological_process 19572
    multicellular organismal process 9168
      multicellular organismal-level homeostasis 923
        homeostasis of number of cells 401
          leukocyte homeostasis 138
            lymphocyte homeostasis 93
              B cell homeostasis 43
                B-1 B cell homeostasis 5
                mature B cell apoptotic process + 5
paths to the root