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ONTOLOGY REPORT - ANNOTATIONS

Term:neutrophil homeostasis
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Accession:GO:0001780 term browser browse the term
Definition:The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Comment:Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus.


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neutrophil homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISO (PMID:21957127)
(MGI:5304979|PMID:21957127)		 RGD PMID:21957127 MGI:5304979 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G C5 complement C5 acts_upstream_of_or_within ISO (MGI:3652641|PMID:16769899) RGD PMID:16769899 MGI:3652641 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G Cfh complement factor H acts_upstream_of_or_within ISO (MGI:3652641|PMID:16769899) RGD PMID:16769899 MGI:3652641 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Jam3 junctional adhesion molecule 3 acts_upstream_of_or_within ISO MGI:3055281 (MGI:3712391|PMID:17455169) RGD PMID:17455169 MGI:3712391 NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355 		JBrowse link
G Mecom MDS1 and EVI1 complex locus acts_upstream_of_or_within ISO MGI:2158381 (MGI:3686680|PMID:17029558) RGD PMID:17029558 MGI:3686680 NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590 		JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor IMP RGD PMID:10606160 RGD:10449003 NCBI chr 5:131,973,897...131,987,472
Ensembl chr 5:131,973,895...131,986,797 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (MGI:5503248|PMID:23704330) RGD PMID:23704330 MGI:5503248 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Pde4b phosphodiesterase 4B involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2181444 (MGI:3521611|PMID:15585880)		 Ensembl
RGD		 PMID:15585880 GO_REF:0000107 MGI:3521611 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P35951 (MGI:5905608|PMID:27430239)		 Ensembl
RGD		 PMID:27430239 GO_REF:0000107 MGI:5905608 NCBI chr12:34,749,849...34,753,616
Ensembl chr12:34,731,911...34,753,616 		JBrowse link
G Slc37a4 solute carrier family 37 member 4 acts_upstream_of_or_within ISO MGI:3046091 (MGI:3695950|PMID:16891306) RGD PMID:16891306 MGI:3695950 NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301 		JBrowse link
negative regulation of neutrophil apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcr2 C-X-C motif chemokine receptor 2 IMP RGD PMID:22312020 RGD:7257693 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Fcgr2b Fc gamma receptor IIb IMP RGD PMID:19106808 RGD:5147925 NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Il18 interleukin 18 IMP RGD PMID:20844839 RGD:8655995 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B acts_upstream_of_or_within ISO MGI:2680720 (MGI:3778329|PMID:18339802) RGD PMID:18339802 MGI:3778329 NCBI chr13:92,069,160...92,164,281
Ensembl chr13:92,069,216...92,162,004 		JBrowse link
neutrophil apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hcar2 hydroxycarboxylic acid receptor 2 involved_in ISO (PMID:17932499) RGD PMID:17932499 NCBI chr12:32,726,334...32,727,416
Ensembl chr12:32,726,184...32,728,504 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO MGI:1857184 (MGI:2673020|PMID:12925700) RGD PMID:12925700 MGI:2673020 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il6 interleukin 6 involved_in
acts_upstream_of_or_within		 ISO (PMID:7595060)
MGI:1857197 (MGI:2673020|PMID:12925700)		 RGD PMID:7595060 PMID:12925700 MGI:2673020 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M involved_in ISO (MGI:85444|PMID:8986723) RGD PMID:8986723 MGI:85444 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
neutrophil clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IBA
ISO		 PMID:21873635
(PMID:21957127)		 RGD PMID:21957127 PMID:21873635 RGD:13792537 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Axl Axl receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:96965 (MGI:5509105|PMID:23878224) RGD PMID:23878224 MGI:5509105 NCBI chr 1:81,265,656...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 acts_upstream_of_or_within ISO MGI:2158345 (MGI:1100445|PMID:9342361) RGD PMID:9342361 MGI:1100445 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18768881)		 UniProt
RGD		 PMID:18768881 GO_REF:0000024 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase acts_upstream_of_or_within ISO MGI:1347244 (MGI:5509105|PMID:23878224) RGD PMID:23878224 MGI:5509105 NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554 		JBrowse link
G Xkr8 XK related 8 involved_in ISO
IEA		 (MGI:6120635|PMID:29440417)
GO_REF:0000107		 RGD
Ensembl		 PMID:29440417 GO_REF:0000107 MGI:6120635 NCBI chr 5:144,938,061...144,945,195
Ensembl chr 5:144,938,064...144,945,195 		JBrowse link
positive regulation of neutrophil apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IBA
ISO		 PMID:21873635
(MGI:5304979|PMID:21957127)		 RGD PMID:21957127 PMID:21873635 MGI:5304979, RGD:13792537 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) IMP RGD PMID:11044212 RGD:2289387 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Fcar Fc alpha receptor involved_in ISO (PMID:25339672) RGD PMID:25339672 NCBI chr 1:69,626,458...69,660,558 JBrowse link
G Hcar2 hydroxycarboxylic acid receptor 2 involved_in ISO
ISS		 (PMID:17932499)
GO_REF:0000024		 RGD
UniProt		 PMID:17932499 GO_REF:0000024 NCBI chr12:32,726,334...32,727,416
Ensembl chr12:32,726,184...32,728,504 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta involved_in IEA
ISO		 GO_REF:0000107
(PMID:25339672)		 Ensembl
RGD		 PMID:25339672 GO_REF:0000107 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta involved_in ISO (PMID:25339672) RGD PMID:25339672 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
regulation of neutrophil apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:3608695 (MGI:3710059|PMID:17200146) RGD PMID:17200146 MGI:3710059 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    immune system process 2829
      myeloid cell homeostasis 199
        neutrophil homeostasis 28
          neutrophil apoptotic process + 14
          neutrophil clearance 6
Path 2
Term Annotations click to browse term
  biological_process 19497
    biological regulation 13606
      regulation of biological quality 4205
        homeostatic process 2024
          homeostasis of number of cells 364
            leukocyte homeostasis 118
              neutrophil homeostasis 28
                neutrophil apoptotic process + 14
                neutrophil clearance 6
paths to the root