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ONTOLOGY REPORT - ANNOTATIONS

Term:natural killer cell differentiation
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Accession:GO:0001779 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: NK cell differentiation
 related_synonym: natural killer cell development

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natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl AXL receptor tyrosine kinase involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936661:3,658,140...3,687,290
Ensembl chrNW_004936661:3,657,831...3,687,816 		JBrowse link
G Flt3lg fms related receptor tyrosine kinase 3 ligand involved_in
acts_upstream_of 		ISO (PMID:38701783)
(PMID:14607906) 		UniProt
MGI		 PMID:14607906 PMID:38701783 NCBI chrNW_004936664:3,343,541...3,351,590
Ensembl chrNW_004936664:3,343,491...3,350,176 		JBrowse link
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO (PMID:24855001) MGI PMID:24855001 NCBI chrNW_004936494:5,761,801...5,853,673
Ensembl chrNW_004936494:5,758,347...5,851,952 		JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:5,236,175...5,238,689
Ensembl chrNW_004936532:5,236,037...5,238,881 		JBrowse link
G Ikzf1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO (PMID:7923373) MGI PMID:7923373 NCBI chrNW_004936686:1,459,582...1,556,478
Ensembl chrNW_004936686:1,462,145...1,556,451 		JBrowse link
G Il11ra interleukin 11 receptor subunit alpha acts_upstream_of_or_within ISO (PMID:15499555) MGI PMID:15499555 NCBI chrNW_004936524:2,732,477...2,743,044
Ensembl chrNW_004936524:2,735,507...2,742,660 		JBrowse link
G Il15 interleukin 15 acts_upstream_of ISO (PMID:14607906) MGI PMID:14607906 NCBI chrNW_004936535:6,344,348...6,358,803
Ensembl chrNW_004936535:6,344,395...6,350,197 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936484:8,590,945...8,623,478
Ensembl chrNW_004936484:8,590,482...8,623,469 		JBrowse link
G Il21 interleukin 21 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936662:1,689,879...1,696,883
Ensembl chrNW_004936662:1,689,879...1,696,883 		JBrowse link
G Kat7 lysine acetyltransferase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:11,775,224...11,805,489
Ensembl chrNW_004936490:11,772,046...11,805,759 		JBrowse link
G Kctd9 potassium channel tetramerization domain containing 9 acts_upstream_of_or_within ISO (PMID:31024568) MGI PMID:31024568 NCBI chrNW_004936757:1,250,089...1,276,089
Ensembl chrNW_004936757:1,250,039...1,276,089 		JBrowse link
G LOC101954516 signal transducer and activator of transcription 5B acts_upstream_of_or_within ISO
IEA 		(PMID:10072077) MGI
Ensembl		 PMID:10072077 GO_REF:0000107 NCBI chrNW_004936490:17,022,268...17,043,751
Ensembl chrNW_004936490:17,021,051...17,043,941 		JBrowse link
G LOC101954799 signal transducer and activator of transcription 5A acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:17,095,047...17,115,945
Ensembl chrNW_004936490:17,095,954...17,114,866 		JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936783:607,425...704,879
Ensembl chrNW_004936783:607,382...704,889 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936796:367,461...369,469
Ensembl chrNW_004936796:367,759...369,150 		JBrowse link
G Pbx1 PBX homeobox 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:20,200,236...20,440,623
Ensembl chrNW_004936481:20,203,405...20,440,629 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936567:5,266,653...5,378,464
Ensembl chrNW_004936567:5,267,615...5,378,258 		JBrowse link
G Rabl3 RAB, member of RAS oncogene family like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936536:7,366,669...7,417,951
Ensembl chrNW_004936536:7,366,625...7,418,679 		JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936740:55,941...92,100
Ensembl chrNW_004936740:55,941...92,100 		JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:18031695) UniProt PMID:18031695 NCBI chrNW_004936740:155,268...165,536 JBrowse link
G Sp3 Sp3 transcription factor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936509:3,740,393...3,782,873
Ensembl chrNW_004936509:3,741,836...3,793,136 		JBrowse link
G Tcf3 transcription factor 3 acts_upstream_of_or_within ISO (PMID:17452521) MGI PMID:17452521 NCBI chrNW_004936588:884,817...913,052
Ensembl chrNW_004936588:884,789...912,753 		JBrowse link
G Tox thymocyte selection associated high mobility group box involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936496:13,847,210...14,146,110
Ensembl chrNW_004936496:13,847,210...14,147,886 		JBrowse link
G TUSC2 tumor suppressor 2, mitochondrial calcium regulator acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chrNW_004936529:1,853,120...1,856,637 JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:4,893,185...4,910,779
Ensembl chrNW_004936471:4,893,078...4,910,859 		JBrowse link
G Znf683 zinc finger protein 683 acts_upstream_of_or_within ISO (PMID:22885984) MGI PMID:22885984 NCBI chrNW_004936474:10,851,249...10,859,092 JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101970371 peptidoglycan recognition protein 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:3,184,904...3,197,203
Ensembl chrNW_004936580:3,184,904...3,194,319 		JBrowse link
G Pglyrp1 peptidoglycan recognition protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:2,317,137...2,320,993
Ensembl chrNW_004936706:2,315,132...2,320,796 		JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936596:5,038,452...5,043,172
Ensembl chrNW_004936596:5,038,452...5,044,569 		JBrowse link
positive regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl AXL receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936661:3,658,140...3,687,290
Ensembl chrNW_004936661:3,657,831...3,687,816 		JBrowse link
G Flt3lg fms related receptor tyrosine kinase 3 ligand acts_upstream_of_or_within ISO (PMID:14607906) MGI PMID:14607906 NCBI chrNW_004936664:3,343,541...3,351,590
Ensembl chrNW_004936664:3,343,491...3,350,176 		JBrowse link
G Gas6 growth arrest specific 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:27,116...57,158
Ensembl chrNW_004936472:32,123...54,028 		JBrowse link
G Il15 interleukin 15 acts_upstream_of_or_within ISO (PMID:17318811)
(PMID:14607906) 		MGI PMID:14607906 PMID:17318811 NCBI chrNW_004936535:6,344,348...6,358,803
Ensembl chrNW_004936535:6,344,395...6,350,197 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936484:8,590,945...8,623,478
Ensembl chrNW_004936484:8,590,482...8,623,469 		JBrowse link
G Il21 interleukin 21 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936662:1,689,879...1,696,883
Ensembl chrNW_004936662:1,689,879...1,696,883 		JBrowse link
G LOC101954516 signal transducer and activator of transcription 5B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:17,022,268...17,043,751
Ensembl chrNW_004936490:17,021,051...17,043,941 		JBrowse link
G LOC101954799 signal transducer and activator of transcription 5A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:17,095,047...17,115,945
Ensembl chrNW_004936490:17,095,954...17,114,866 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:2,152,231...2,222,260
Ensembl chrNW_004936471:2,153,880...2,222,229 		JBrowse link
G Tox thymocyte selection associated high mobility group box acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936496:13,847,210...14,146,110
Ensembl chrNW_004936496:13,847,210...14,147,886 		JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 involved_in ISO (PMID:22753936) UniProt PMID:22753936 NCBI chrNW_004936495:8,212,136...8,238,876 JBrowse link
regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (PMID:23408620) UniProt PMID:23408620 NCBI chrNW_004936538:4,034,467...4,050,240 JBrowse link
G Prdm1 PR/SET domain 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936564:2,594,362...2,690,680
Ensembl chrNW_004936564:2,667,660...2,690,683 		JBrowse link
G Znf683 zinc finger protein 683 involved_in ISO (PMID:27102484) UniProt PMID:27102484 NCBI chrNW_004936474:10,851,249...10,859,092 JBrowse link
regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Znf683 zinc finger protein 683 involved_in ISO (PMID:22885984) UniProt PMID:22885984 NCBI chrNW_004936474:10,851,249...10,859,092 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17413
    immune system process 2310
      leukocyte activation 952
        lymphocyte activation 778
          lymphocyte differentiation 418
            natural killer cell differentiation 34
              natural killer cell differentiation involved in immune response + 4
              negative regulation of natural killer cell differentiation + 3
              positive regulation of natural killer cell differentiation + 11
              regulation of natural killer cell differentiation + 17
Path 2
Term Annotations click to browse term
  biological_process 17413
    developmental process 6463
      cellular developmental process 4360
        cell differentiation 4359
          cell development 3130
            hemopoiesis 990
              leukocyte differentiation 633
                mononuclear cell differentiation 511
                  lymphocyte differentiation 418
                    natural killer cell differentiation 34
                      natural killer cell differentiation involved in immune response + 4
                      negative regulation of natural killer cell differentiation + 3
                      positive regulation of natural killer cell differentiation + 11
                      regulation of natural killer cell differentiation + 17
paths to the root