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ONTOLOGY REPORT - ANNOTATIONS

Term:natural killer cell differentiation
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Accession:GO:0001779 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: NK cell differentiation
 related_synonym: natural killer cell development


show annotations for term's descendants           Sort by:
natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:104294|MGI:96965 (PMID:16751775)		 GO_Central
RGD		 PMID:16751775 GO_REF:0000033 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand acts_upstream_of ISO MGI:2158499 (PMID:14607906) RGD PMID:14607906 NCBI chr 1:95,615,056...95,620,463
Ensembl chr 1:95,609,370...95,620,463 		JBrowse link
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO MGI:2137552 (PMID:24855001) RGD PMID:24855001 NCBI chr 6:69,181,429...69,268,045
Ensembl chr 6:69,181,436...69,268,053 		JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO MGI:2384134|MGI:98510 (PMID:17452521) RGD PMID:17452521 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Ikzf1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO MGI:2158738 (PMID:7923373) RGD PMID:7923373 NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416 		JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 acts_upstream_of_or_within ISO MGI:2177774 (PMID:15499555) RGD PMID:15499555 NCBI chr 5:56,931,824...56,941,408
Ensembl chr 5:56,935,516...56,941,408 		JBrowse link
G Il15 interleukin 15 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:2136897 (PMID:14607906)		 Ensembl
RGD		 PMID:14607906 GO_REF:0000107 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha acts_upstream_of ISO MGI:1934016 (PMID:14607906) RGD PMID:14607906 NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278 		JBrowse link
G Il21 interleukin 21 acts_upstream_of ISO (PMID:14764669) RGD PMID:14764669 NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Kat7 lysine acetyltransferase 7 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6393224|PMID:27733580)		 UniProt
RGD		 PMID:27733580 GO_REF:0000024 MGI:6393224 NCBI chr10:80,221,519...80,255,590
Ensembl chr10:80,221,524...80,255,567 		JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase acts_upstream_of_or_within ISO MGI:104294|MGI:1347244 (PMID:16751775) RGD PMID:16751775 NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated involved_in ISS
ISO		 GO_REF:0000024
(MGI:6460593|PMID:32190943)		 UniProt
RGD		 PMID:32190943 GO_REF:0000024 MGI:6460593 NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858 		JBrowse link
G Pbx1 PBX homeobox 1 involved_in ISO (MGI:6460593|PMID:32190943) RGD PMID:32190943 MGI:6460593 NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in ISO (MGI:3521537|PMID:15557316) RGD PMID:15557316 MGI:3521537 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Rabl3 RAB, member of RAS oncogene family-like 3 involved_in ISO (MGI:6405642|PMID:32220963) RGD PMID:32220963 MGI:6405642 NCBI chr11:63,153,281...63,182,240
Ensembl chr11:63,152,792...63,182,671 		JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 involved_in ISO (MGI:3763993|PMID:18031695) RGD PMID:18031695 MGI:3763993 NCBI chr13:84,270,316...84,305,497
Ensembl chr13:84,270,316...84,305,497 		JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (MGI:3763993|PMID:18031695) RGD PMID:18031695 MGI:3763993 NCBI chr13:84,384,561...84,405,300
Ensembl chr13:84,383,742...84,405,300 		JBrowse link
G Sp3 Sp3 transcription factor acts_upstream_of_or_within ISO MGI:2182438 (PMID:12676787) RGD PMID:12676787 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:103035 (PMID:10072077)
MGI:1857249 (PMID:9841920)		 RGD PMID:9841920 PMID:10072077 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2181592 (PMID:9841920)
MGI:103036 (PMID:10072077)		 Ensembl
RGD		 PMID:9841920 PMID:10072077 GO_REF:0000107 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Tcf3 transcription factor 3 acts_upstream_of_or_within ISO MGI:96397 (PMID:17452521) RGD PMID:17452521 NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314 		JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in ISO (PMID:21126536) RGD PMID:21126536 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272 		JBrowse link
G Tusc2 tumor suppressor 2, mitochondrial calcium regulator acts_upstream_of_or_within ISO MGI:103014|MGI:3706236 (PMID:17318811) RGD PMID:17318811 NCBI chr 8:108,236,838...108,240,056
Ensembl chr 8:108,236,838...108,240,056 		JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1347244|MGI:96965 (PMID:16751775)		 Ensembl
RGD		 PMID:16751775 GO_REF:0000107 NCBI chr 3:106,777,686...106,797,154
Ensembl chr 3:106,777,635...106,797,142 		JBrowse link
G Zfp683 zinc finger protein 683 acts_upstream_of_or_within ISO MGI:4276801 (PMID:22885984) RGD PMID:22885984 NCBI chr 5:146,277,972...146,285,856
Ensembl chr 5:146,278,978...146,285,000 		JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pglyrp1 peptidoglycan recognition protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2670590 (PMID:20709292)		 Ensembl
RGD		 PMID:20709292 GO_REF:0000107 NCBI chr 1:78,531,815...78,537,001
Ensembl chr 1:78,531,815...78,537,001 		JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 acts_upstream_of_or_within ISO MGI:5297105 (PMID:20709292) RGD PMID:20709292 NCBI chr 7:11,418,674...11,432,162
Ensembl chr 7:11,418,880...11,427,773 		JBrowse link
G Pglyrp3 peptidoglycan recognition protein 3 acts_upstream_of_or_within ISO MGI:5297106 (PMID:20709292) RGD PMID:20709292 NCBI chr 2:177,479,693...177,490,769
Ensembl chr 2:177,477,407...177,490,736
Ensembl chr 2:177,477,407...177,490,736 		JBrowse link
G Pglyrp4 peptidoglycan recognition protein 4 acts_upstream_of_or_within ISO MGI:5297107 (PMID:20709292) RGD PMID:20709292 NCBI chr 2:176,202,654...176,322,859
Ensembl chr 2:176,218,519...176,242,251 		JBrowse link
positive regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase involved_in ISO (PMID:18840707) RGD PMID:18840707 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand acts_upstream_of_or_within ISO MGI:2158499 (PMID:14607906) RGD PMID:14607906 NCBI chr 1:95,615,056...95,620,463
Ensembl chr 1:95,609,370...95,620,463 		JBrowse link
G Gas6 growth arrest specific 6 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18840707)		 UniProt
RGD		 PMID:18840707 GO_REF:0000024 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Il15 interleukin 15 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1931086|MGI:2136897 (PMID:14607906), (PMID:17318811)		 Ensembl
RGD		 PMID:14607906 PMID:17318811 GO_REF:0000107 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha acts_upstream_of_or_within ISO MGI:1934016 (PMID:14607906) RGD PMID:14607906 NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278 		JBrowse link
G Il21 interleukin 21 acts_upstream_of_or_within ISO (PMID:14764669) RGD PMID:14764669 NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in ISO
IEA		 (MGI:5302428|PMID:21957144)
GO_REF:0000107		 RGD
Ensembl		 PMID:21957144 GO_REF:0000107 MGI:5302428 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:1857249 (PMID:9841920) RGD PMID:9841920 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2181592 (PMID:9841920)		 Ensembl
RGD		 PMID:9841920 GO_REF:0000107 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Tox thymocyte selection-associated high mobility group box acts_upstream_of_or_within ISO MGI:3773716 (PMID:20818394) RGD PMID:20818394 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272 		JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 involved_in ISO (MGI:5446979|PMID:22753936) RGD PMID:22753936 MGI:5446979 NCBI chr 6:95,096,838...95,125,811
Ensembl chr 6:95,096,387...95,118,996 		JBrowse link
regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (MGI:5491117|PMID:23408620) RGD PMID:23408620 MGI:5491117 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Prdm1 PR/SET domain 1 involved_in ISO (MGI:5779429|PMID:27102484) RGD PMID:27102484 MGI:5779429 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488 		JBrowse link
G Zfp683 zinc finger protein 683 involved_in ISO (MGI:5779429|PMID:27102484) RGD PMID:27102484 MGI:5779429 NCBI chr 5:146,277,972...146,285,856
Ensembl chr 5:146,278,978...146,285,000 		JBrowse link
regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zfp683 zinc finger protein 683 involved_in ISO (MGI:5437828|PMID:22885984) RGD PMID:22885984 MGI:5437828 NCBI chr 5:146,277,972...146,285,856
Ensembl chr 5:146,278,978...146,285,000 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    immune system process 3017
      leukocyte activation 1052
        lymphocyte activation 851
          lymphocyte differentiation 448
            natural killer cell differentiation 34
              natural killer cell differentiation involved in immune response + 5
              negative regulation of natural killer cell differentiation + 4
              positive regulation of natural killer cell differentiation + 11
              regulation of natural killer cell differentiation + 18
Path 2
Term Annotations click to browse term
  biological_process 20413
    developmental process 7068
      cellular developmental process 4768
        cell differentiation 4767
          cell development 3311
            hemopoiesis 1064
              leukocyte differentiation 676
                mononuclear cell differentiation 545
                  lymphocyte differentiation 448
                    natural killer cell differentiation 34
                      natural killer cell differentiation involved in immune response + 5
                      negative regulation of natural killer cell differentiation + 4
                      positive regulation of natural killer cell differentiation + 11
                      regulation of natural killer cell differentiation + 18
paths to the root