Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:natural killer cell differentiation
go back to main search page
Accession:GO:0001779 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: NK cell differentiation
 related_synonym: natural killer cell development

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl AXL receptor tyrosine kinase acts_upstream_of_or_within
involved_in 		ISO
IEA 		(PMID:16751775) MGI
TreeGrafter		 PMID:16751775 GO_REF:0000118 NCBI chrNW_004624907:76,236...106,765
Ensembl chrNW_004624907:77,806...106,228 		JBrowse link
G Flt3lg fms related receptor tyrosine kinase 3 ligand acts_upstream_of
involved_in 		ISO (PMID:14607906)
(PMID:38701783) 		MGI
UniProt		 PMID:14607906 PMID:38701783 NCBI chrNW_004624832:4,733,820...4,739,214 JBrowse link
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO (PMID:24855001) MGI PMID:24855001 NCBI chrNW_004624820:1,097,323...1,196,556
Ensembl chrNW_004624820:1,097,463...1,196,499 		JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO (PMID:17452521) MGI PMID:17452521 NCBI chrNW_004624846:2,281,292...2,283,596
Ensembl chrNW_004624846:2,277,961...2,283,571 		JBrowse link
G Ikzf1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO (PMID:7923373) MGI PMID:7923373 NCBI chrNW_004624740:3,785,342...3,875,892
Ensembl chrNW_004624740:3,785,209...3,875,841 		JBrowse link
G Il11ra interleukin 11 receptor subunit alpha acts_upstream_of_or_within ISO (PMID:15499555) MGI PMID:15499555 NCBI chrNW_004624736:39,043,972...39,055,689
Ensembl chrNW_004624736:39,046,176...39,055,306 		JBrowse link
G Il15 interleukin 15 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004624853:1,059,625...1,144,799
Ensembl chrNW_004624853:1,128,519...1,144,941 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha acts_upstream_of ISO (PMID:14607906) MGI PMID:14607906 NCBI chrNW_004624775:846,063...877,894
Ensembl chrNW_004624775:847,677...877,604 		JBrowse link
G Il21 interleukin 21 acts_upstream_of ISO (PMID:14764669) MGI PMID:14764669 NCBI chrNW_004624777:3,054,368...3,061,304
Ensembl chrNW_004624777:3,054,368...3,061,304 		JBrowse link
G Kat7 lysine acetyltransferase 7 involved_in ISO (PMID:27733580) UniProt PMID:27733580 NCBI chrNW_004624795:5,859,974...5,892,519
Ensembl chrNW_004624795:5,859,443...5,892,527 		JBrowse link
G Kctd9 potassium channel tetramerization domain containing 9 acts_upstream_of_or_within ISO (PMID:31024568) MGI PMID:31024568 NCBI chrNW_004624758:20,454,965...20,490,302
Ensembl chrNW_004624758:20,454,965...20,488,868 		JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase acts_upstream_of_or_within ISO (PMID:16751775) MGI PMID:16751775 NCBI chrNW_004624749:337,441...444,730
Ensembl chrNW_004624749:341,289...443,640 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624868:1,139,575...1,150,370
Ensembl chrNW_004624868:1,139,595...1,150,370 		JBrowse link
G Pbx1 PBX homeobox 1 involved_in ISO (PMID:32190943) UniProt PMID:32190943 NCBI chrNW_004624826:2,944,272...3,250,957
Ensembl chrNW_004624826:2,945,004...3,215,110 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C involved_in ISO (PMID:15557316) ARUK-UCL PMID:15557316 NCBI chrNW_004624798:1,700,732...1,814,603
Ensembl chrNW_004624798:1,699,541...1,814,656 		JBrowse link
G Rabl3 RAB, member of RAS oncogene family like 3 involved_in ISO (PMID:32220963) UniProt PMID:32220963 NCBI chrNW_004624731:27,484,856...27,537,365
Ensembl chrNW_004624731:27,484,497...27,535,436 		JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 involved_in ISO (PMID:18031695) UniProt PMID:18031695 NCBI chrNW_004624794:627,906...661,257 JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:18031695) UniProt PMID:18031695 NCBI chrNW_004624794:754,530...796,732 JBrowse link
G Sp3 Sp3 transcription factor acts_upstream_of_or_within ISO (PMID:12676787) MGI PMID:12676787 NCBI chrNW_004624787:11,144,581...11,193,520 JBrowse link
G Tcf3 transcription factor 3 acts_upstream_of_or_within ISO (PMID:17452521) MGI PMID:17452521 NCBI chrNW_004624828:7,090,562...7,119,970
Ensembl chrNW_004624828:7,090,605...7,121,428 		JBrowse link
G Tox thymocyte selection associated high mobility group box involved_in ISO (PMID:21126536) UniProt PMID:21126536 NCBI chrNW_004624744:32,865,781...33,218,453
Ensembl chrNW_004624744:32,865,720...33,218,643 		JBrowse link
G Tusc2 tumor suppressor 2, mitochondrial calcium regulator acts_upstream_of_or_within ISO (PMID:17318811) MGI PMID:17318811 NCBI chrNW_004624730:4,177,351...4,181,036 JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase acts_upstream_of_or_within ISO (PMID:16751775) MGI PMID:16751775 NCBI chrNW_004624804:8,711,487...8,729,025
Ensembl chrNW_004624804:8,710,821...8,728,072 		JBrowse link
G Znf683 zinc finger protein 683 acts_upstream_of_or_within ISO (PMID:22885984) MGI PMID:22885984 NCBI chrNW_004624764:10,382,733...10,388,608 JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pglyrp1 peptidoglycan recognition protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624832:7,220,739...7,225,146
Ensembl chrNW_004624832:7,221,064...7,224,615 		JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 acts_upstream_of_or_within ISO (PMID:20709292) MGI PMID:20709292 NCBI chrNW_004624901:2,554,303...2,562,436
Ensembl chrNW_004624901:2,554,048...2,561,826 		JBrowse link
positive regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl AXL receptor tyrosine kinase involved_in ISO (PMID:18840707) UniProt PMID:18840707 NCBI chrNW_004624907:76,236...106,765
Ensembl chrNW_004624907:77,806...106,228 		JBrowse link
G Flt3lg fms related receptor tyrosine kinase 3 ligand acts_upstream_of_or_within ISO (PMID:14607906) MGI PMID:14607906 NCBI chrNW_004624832:4,733,820...4,739,214 JBrowse link
G Gas6 growth arrest specific 6 involved_in ISO (PMID:18840707) UniProt PMID:18840707 NCBI chrNW_004624793:385,846...410,934
Ensembl chrNW_004624793:385,812...410,934 		JBrowse link
G Il15 interleukin 15 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624853:1,059,625...1,144,799
Ensembl chrNW_004624853:1,128,519...1,144,941 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha acts_upstream_of_or_within ISO (PMID:14607906) MGI PMID:14607906 NCBI chrNW_004624775:846,063...877,894
Ensembl chrNW_004624775:847,677...877,604 		JBrowse link
G Il21 interleukin 21 acts_upstream_of_or_within ISO (PMID:14764669) MGI PMID:14764669 NCBI chrNW_004624777:3,054,368...3,061,304
Ensembl chrNW_004624777:3,054,368...3,061,304 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624804:5,691,011...5,763,314
Ensembl chrNW_004624804:5,690,400...5,763,288 		JBrowse link
G Tox thymocyte selection associated high mobility group box acts_upstream_of_or_within ISO (PMID:20818394) MGI PMID:20818394 NCBI chrNW_004624744:32,865,781...33,218,453
Ensembl chrNW_004624744:32,865,720...33,218,643 		JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 involved_in ISO (PMID:22753936) UniProt PMID:22753936 NCBI chrNW_004624734:36,479,670...36,509,655 JBrowse link
regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (PMID:23408620) UniProt PMID:23408620 NCBI chrNW_004624786:478,048...491,086 JBrowse link
G Prdm1 PR/SET domain 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624780:16,205,056...16,227,382
Ensembl chrNW_004624780:16,204,838...16,227,390 		JBrowse link
G Znf683 zinc finger protein 683 involved_in ISO (PMID:27102484) UniProt PMID:27102484 NCBI chrNW_004624764:10,382,733...10,388,608 JBrowse link
regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Znf683 zinc finger protein 683 involved_in ISO (PMID:22885984) UniProt PMID:22885984 NCBI chrNW_004624764:10,382,733...10,388,608 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17646
    immune system process 2290
      leukocyte activation 931
        lymphocyte activation 756
          lymphocyte differentiation 405
            natural killer cell differentiation 31
              natural killer cell differentiation involved in immune response + 3
              negative regulation of natural killer cell differentiation + 2
              positive regulation of natural killer cell differentiation + 9
              regulation of natural killer cell differentiation + 14
Path 2
Term Annotations click to browse term
  biological_process 17646
    developmental process 6435
      cellular developmental process 4329
        cell differentiation 4328
          cell development 3074
            hemopoiesis 950
              leukocyte differentiation 611
                mononuclear cell differentiation 495
                  lymphocyte differentiation 405
                    natural killer cell differentiation 31
                      natural killer cell differentiation involved in immune response + 3
                      negative regulation of natural killer cell differentiation + 2
                      positive regulation of natural killer cell differentiation + 9
                      regulation of natural killer cell differentiation + 14
paths to the root