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ONTOLOGY REPORT - ANNOTATIONS

Term:natural killer cell differentiation
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Accession:GO:0001779 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: NK cell differentiation
 related_synonym: natural killer cell development


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natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AXL AXL receptor tyrosine kinase involved_in
acts_upstream_of_or_within 		IBA
IEA 		GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr19:41,219,223...41,261,766
Ensembl chr19:41,219,223...41,261,766 		JBrowse link
G FLT3LG fms related receptor tyrosine kinase 3 ligand acts_upstream_of
involved_in 		ISO (PMID:14607906)
(PMID:38701783) 		MGI
UniProt		 PMID:14607906 PMID:38701783 NCBI chr19:49,474,215...49,486,231
Ensembl chr19:49,474,207...49,486,231 		JBrowse link
G HECTD1 HECT domain E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO (PMID:24855001) MGI PMID:24855001 NCBI chr14:31,100,117...31,207,793
Ensembl chr14:31,100,117...31,207,804 		JBrowse link
G ID2 inhibitor of DNA binding 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461 		JBrowse link
G IKZF1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO (PMID:7923373) MGI PMID:7923373 NCBI chr 7:50,303,455...50,405,101
Ensembl chr 7:50,304,068...50,405,101 		JBrowse link
G IL11RA interleukin 11 receptor subunit alpha acts_upstream_of_or_within ISO (PMID:15499555) MGI PMID:15499555 NCBI chr 9:34,652,185...34,661,902
Ensembl chr 9:34,652,162...34,661,902 		JBrowse link
G IL15 interleukin 15 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 4:141,636,583...141,733,987
Ensembl chr 4:141,636,583...141,733,987 		JBrowse link
G IL15RA interleukin 15 receptor subunit alpha acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr10:5,948,900...5,978,741
Ensembl chr10:5,943,639...5,978,187 		JBrowse link
G IL21 interleukin 21 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 4:122,610,108...122,621,066
Ensembl chr 4:122,610,108...122,621,066 		JBrowse link
G KAT7 lysine acetyltransferase 7 involved_in ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:49,788,681...49,835,026
Ensembl chr17:49,788,624...49,835,026 		JBrowse link
G KCTD9 potassium channel tetramerization domain containing 9 acts_upstream_of_or_within ISO (PMID:31024568) MGI PMID:31024568 NCBI chr 8:25,427,847...25,458,433
Ensembl chr 8:25,427,847...25,458,476 		JBrowse link
G MERTK MER proto-oncogene, tyrosine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:111,898,607...112,029,561
Ensembl chr 2:111,898,607...112,029,561 		JBrowse link
G NFIL3 nuclear factor, interleukin 3 regulated involved_in IEA
ISS 		Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:91,409,045...91,483,497
Ensembl chr 9:91,408,748...91,424,626 		JBrowse link
G PBX1 PBX homeobox 1 involved_in IEA
ISS 		Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:164,559,184...164,886,047
Ensembl chr 1:164,555,584...164,899,296 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta involved_in TAS (PMID:20940048) UniProt PMID:20940048 NCBI chr 1:9,627,258...9,729,114
Ensembl chr 1:9,629,889...9,729,114 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in ISS
IEA 		ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:198,638,713...198,757,476
Ensembl chr 1:198,638,457...198,759,342 		JBrowse link
G RABL3 RAB, member of RAS oncogene family like 3 involved_in ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:120,684,938...120,742,680
Ensembl chr 3:120,684,938...120,742,993 		JBrowse link
G SLAMF1 signaling lymphocytic activation molecule family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:160,608,106...160,647,044
Ensembl chr 1:160,608,106...160,647,044 		JBrowse link
G SLAMF6 SLAM family member 6 involved_in ISO (PMID:18031695) UniProt PMID:18031695 NCBI chr 1:160,485,036...160,523,255
Ensembl chr 1:160,485,030...160,523,262 		JBrowse link
G SP3 Sp3 transcription factor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:173,900,775...173,965,702
Ensembl chr 2:173,880,850...173,965,373 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO
IEA 		(PMID:10072077) MGI
Ensembl		 PMID:10072077 GO_REF:0000107 NCBI chr17:42,287,439...42,311,943
Ensembl chr17:42,287,547...42,311,943 		JBrowse link
G STAT5B signal transducer and activator of transcription 5B acts_upstream_of_or_within ISO
IEA 		(PMID:10072077) MGI
Ensembl		 PMID:10072077 GO_REF:0000107 NCBI chr17:42,199,177...42,288,370
Ensembl chr17:42,199,176...42,288,633 		JBrowse link
G TCF3 transcription factor 3 acts_upstream_of_or_within ISO (PMID:17452521) MGI PMID:17452521 NCBI chr19:1,609,292...1,652,615
Ensembl chr19:1,609,291...1,652,615 		JBrowse link
G TOX thymocyte selection associated high mobility group box involved_in IMP (PMID:21126536) UniProt PMID:21126536 NCBI chr 8:58,805,412...59,119,147
Ensembl chr 8:58,805,412...59,119,147 		JBrowse link
G TUSC2 tumor suppressor 2, mitochondrial calcium regulator acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:50,324,909...50,328,223
Ensembl chr 3:50,320,027...50,328,251 		JBrowse link
G TYRO3 TYRO3 protein tyrosine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr15:41,559,212...41,583,589
Ensembl chr15:41,557,675...41,583,589 		JBrowse link
G ZNF683 zinc finger protein 683 acts_upstream_of_or_within ISO (PMID:22885984) MGI PMID:22885984 NCBI chr 1:26,361,634...26,374,518
Ensembl chr 1:26,361,634...26,374,522 		JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PGLYRP1 peptidoglycan recognition protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr19:46,019,153...46,023,053
Ensembl chr19:46,019,153...46,023,053 		JBrowse link
G PGLYRP2 peptidoglycan recognition protein 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr19:15,468,645...15,479,501
Ensembl chr19:15,468,645...15,498,956 		JBrowse link
G PGLYRP3 peptidoglycan recognition protein 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:153,297,116...153,312,952
Ensembl chr 1:153,297,116...153,312,952 		JBrowse link
G PGLYRP4 peptidoglycan recognition protein 4 acts_upstream_of_or_within ISO (PMID:20709292) MGI PMID:20709292 NCBI chr 1:153,330,120...153,348,841
Ensembl chr 1:153,330,120...153,348,841 		JBrowse link
positive regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AXL AXL receptor tyrosine kinase involved_in IDA (PMID:18840707) UniProt PMID:18840707 NCBI chr19:41,219,223...41,261,766
Ensembl chr19:41,219,223...41,261,766 		JBrowse link
G FLT3LG fms related receptor tyrosine kinase 3 ligand acts_upstream_of_or_within ISO (PMID:14607906) MGI PMID:14607906 NCBI chr19:49,474,215...49,486,231
Ensembl chr19:49,474,207...49,486,231 		JBrowse link
G GAS6 growth arrest specific 6 involved_in IDA (PMID:18840707) UniProt PMID:18840707 NCBI chr13:113,820,549...113,864,076
Ensembl chr13:113,820,549...113,864,076 		JBrowse link
G IL15 interleukin 15 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:141,636,583...141,733,987
Ensembl chr 4:141,636,583...141,733,987 		JBrowse link
G IL15RA interleukin 15 receptor subunit alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:5,948,900...5,978,741
Ensembl chr10:5,943,639...5,978,187 		JBrowse link
G IL21 interleukin 21 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:122,610,108...122,621,066
Ensembl chr 4:122,610,108...122,621,066 		JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:38,488,103...38,564,814
Ensembl chr15:38,488,103...38,565,575 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:42,287,439...42,311,943
Ensembl chr17:42,287,547...42,311,943 		JBrowse link
G STAT5B signal transducer and activator of transcription 5B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:42,199,177...42,288,370
Ensembl chr17:42,199,176...42,288,633 		JBrowse link
G TOX thymocyte selection associated high mobility group box acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:58,805,412...59,119,147
Ensembl chr 8:58,805,412...59,119,147 		JBrowse link
G ZBTB1 zinc finger and BTB domain containing 1 involved_in ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr14:64,503,716...64,533,693
Ensembl chr14:64,503,712...64,533,690 		JBrowse link
regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LGALS9 galectin 9 involved_in ISO (PMID:23408620) UniProt PMID:23408620 NCBI chr17:27,631,188...27,649,560
Ensembl chr17:27,629,798...27,649,560 		JBrowse link
G PRDM1 PR/SET domain 1 involved_in ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:105,992,690...106,109,938
Ensembl chr 6:105,993,463...106,109,939 		JBrowse link
G ZNF683 zinc finger protein 683 involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:26,361,634...26,374,518
Ensembl chr 1:26,361,634...26,374,522 		JBrowse link
regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZNF683 zinc finger protein 683 involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:26,361,634...26,374,518
Ensembl chr 1:26,361,634...26,374,522 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 27205
    immune system process 3309
      leukocyte activation 1159
        lymphocyte activation 953
          lymphocyte differentiation 511
            natural killer cell differentiation 36
              natural killer cell differentiation involved in immune response + 5
              negative regulation of natural killer cell differentiation + 4
              positive regulation of natural killer cell differentiation + 11
              regulation of natural killer cell differentiation + 18
Path 2
Term Annotations click to browse term
  biological_process 27205
    developmental process 7772
      cellular developmental process 5258
        cell differentiation 5257
          cell development 3499
            hemopoiesis 1181
              leukocyte differentiation 755
                mononuclear cell differentiation 621
                  lymphocyte differentiation 511
                    natural killer cell differentiation 36
                      natural killer cell differentiation involved in immune response + 5
                      negative regulation of natural killer cell differentiation + 4
                      positive regulation of natural killer cell differentiation + 11
                      regulation of natural killer cell differentiation + 18
paths to the root