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ONTOLOGY REPORT - ANNOTATIONS

Term:natural killer cell differentiation
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Accession:GO:0001779 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: NK cell differentiation
 related_synonym: natural killer cell development


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natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AXL AXL receptor tyrosine kinase involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:38,211,555...38,254,464
Ensembl chr19:46,719,615...46,761,747 		JBrowse link
G FLT3LG fms related receptor tyrosine kinase 3 ligand acts_upstream_of
involved_in 		ISO (PMID:14607906)
(PMID:38701783) 		MGI
UniProt		 PMID:14607906 PMID:38701783 NCBI chr19:46,486,169...46,499,008 JBrowse link
G HECTD1 HECT domain E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO (PMID:24855001) MGI PMID:24855001 NCBI chr14:11,871,973...11,979,548
Ensembl chr14:30,070,567...30,176,915 		JBrowse link
G ID2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO (PMID:17452521) MGI PMID:17452521 NCBI chr2A:8,681,592...8,684,014
Ensembl chr2A:8,847,776...8,850,720 		JBrowse link
G IKZF1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO (PMID:7923373) MGI PMID:7923373 NCBI chr 7:50,946,817...51,047,168
Ensembl chr 7:51,191,685...51,291,245 		JBrowse link
G IL15 interleukin 15 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622 		JBrowse link
G IL15RA interleukin 15 receptor subunit alpha acts_upstream_of ISO (PMID:14607906) MGI PMID:14607906 NCBI chr10:5,993,583...6,019,967 JBrowse link
G IL21 interleukin 21 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915 		JBrowse link
G KAT7 lysine acetyltransferase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:43,875,921...43,916,352
Ensembl chr17:48,605,488...48,645,784 		JBrowse link
G KCTD9 potassium channel tetramerization domain containing 9 acts_upstream_of_or_within ISO (PMID:31024568) MGI PMID:31024568 NCBI chr 8:24,708,896...24,739,197
Ensembl chr 8:21,618,042...21,648,309 		JBrowse link
G LOC100988550 signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO
IEA 		(PMID:10072077) MGI
Ensembl		 PMID:10072077 GO_REF:0000107 NCBI chr17:15,005,025...15,029,110
Ensembl chr17:15,228,465...15,251,783 		JBrowse link
G LOC100989105 signal transducer and activator of transcription 5B acts_upstream_of_or_within ISO
IEA 		(PMID:10072077) MGI
Ensembl		 PMID:10072077 GO_REF:0000107 NCBI chr17:15,040,303...15,116,682
Ensembl chr17:15,306,418...15,336,463 		JBrowse link
G MERTK MER proto-oncogene, tyrosine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr2A:89,977,226...90,109,970
Ensembl chr2A:113,056,852...113,162,052 		JBrowse link
G NFIL3 nuclear factor, interleukin 3 regulated involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:62,467,360...62,482,926
Ensembl chr 9:90,567,116...90,568,504 		JBrowse link
G PBX1 PBX homeobox 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:139,985,392...140,311,845
Ensembl chr 1:143,778,701...144,104,797 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:174,246,389...174,364,893
Ensembl chr 1:178,556,104...178,672,994 		JBrowse link
G RABL3 RAB, member of RAS oncogene family like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:117,794,224...117,850,184
Ensembl chr 3:124,707,984...124,748,983 		JBrowse link
G SLAMF1 signaling lymphocytic activation molecule family member 1 involved_in ISO (PMID:18031695) UniProt PMID:18031695 NCBI chr 1:135,963,748...136,002,982
Ensembl chr 1:139,888,772...139,925,461 		JBrowse link
G SLAMF6 SLAM family member 6 involved_in ISO (PMID:18031695) UniProt PMID:18031695 NCBI chr 1:135,838,862...135,878,207
Ensembl chr 1:139,761,121...139,799,348 		JBrowse link
G SP3 Sp3 transcription factor acts_upstream_of_or_within ISO (PMID:12676787) MGI PMID:12676787 NCBI chr2B:61,185,975...61,243,155
Ensembl chr2B:178,639,677...178,692,848 		JBrowse link
G TCF3 transcription factor 3 acts_upstream_of_or_within ISO (PMID:17452521) MGI PMID:17452521 Ensembl chr19:1,582,297...1,622,025 JBrowse link
G TOX thymocyte selection associated high mobility group box involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:55,246,933...55,553,839
Ensembl chr 8:56,922,773...57,219,410 		JBrowse link
G TUSC2 tumor suppressor 2, mitochondrial calcium regulator acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:50,251,034...50,254,351
Ensembl chr 3:51,486,641...51,489,962 		JBrowse link
G TYRO3 TYRO3 protein tyrosine kinase acts_upstream_of_or_within ISO (PMID:16751775) MGI PMID:16751775 NCBI chr15:20,499,789...20,520,152
Ensembl chr15:38,739,509...38,760,288 		JBrowse link
G ZNF683 zinc finger protein 683 acts_upstream_of_or_within ISO (PMID:22885984) MGI PMID:22885984 NCBI chr 1:25,622,548...25,636,106
Ensembl chr 1:26,690,359...26,703,755 		JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PGLYRP1 peptidoglycan recognition protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr19:43,033,080...43,037,726
Ensembl chr19:51,569,275...51,573,764 		JBrowse link
G PGLYRP2 peptidoglycan recognition protein 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr19:14,999,893...15,012,376
Ensembl chr19:15,986,090...15,997,726 		JBrowse link
G PGLYRP3 peptidoglycan recognition protein 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:128,642,034...128,656,082
Ensembl chr 1:132,270,957...132,283,860 		JBrowse link
G PGLYRP4 peptidoglycan recognition protein 4 acts_upstream_of_or_within ISO (PMID:20709292) MGI PMID:20709292 NCBI chr 1:128,681,726...128,700,275
Ensembl chr 1:132,310,256...132,329,013 		JBrowse link
positive regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AXL AXL receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:38,211,555...38,254,464
Ensembl chr19:46,719,615...46,761,747 		JBrowse link
G FLT3LG fms related receptor tyrosine kinase 3 ligand acts_upstream_of_or_within ISO (PMID:14607906) MGI PMID:14607906 NCBI chr19:46,486,169...46,499,008 JBrowse link
G GAS6 growth arrest specific 6 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr13:113,968,843...114,009,562 JBrowse link
G IL15 interleukin 15 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622 		JBrowse link
G IL15RA interleukin 15 receptor subunit alpha acts_upstream_of_or_within ISO (PMID:14607906) MGI PMID:14607906 NCBI chr10:5,993,583...6,019,967 JBrowse link
G IL21 interleukin 21 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915 		JBrowse link
G LOC100988550 signal transducer and activator of transcription 5A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:15,005,025...15,029,110
Ensembl chr17:15,228,465...15,251,783 		JBrowse link
G LOC100989105 signal transducer and activator of transcription 5B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:15,040,303...15,116,682
Ensembl chr17:15,306,418...15,336,463 		JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:17,417,684...17,494,333
Ensembl chr15:35,675,348...35,750,315 		JBrowse link
G TOX thymocyte selection associated high mobility group box acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:55,246,933...55,553,839
Ensembl chr 8:56,922,773...57,219,410 		JBrowse link
G ZBTB1 zinc finger and BTB domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:45,085,146...45,114,965
Ensembl chr14:63,354,458...63,359,403 		JBrowse link
regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100977210 galectin-9 involved_in ISO (PMID:23408620) UniProt PMID:23408620 NCBI chr17:29,125,460...29,145,028
Ensembl chr17:29,623,398...29,642,959 		JBrowse link
G PRDM1 PR/SET domain 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:103,899,410...103,923,389
Ensembl chr 6:107,773,229...107,796,815 		JBrowse link
G ZNF683 zinc finger protein 683 involved_in ISO (PMID:27102484) UniProt PMID:27102484 NCBI chr 1:25,622,548...25,636,106
Ensembl chr 1:26,690,359...26,703,755 		JBrowse link
regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZNF683 zinc finger protein 683 involved_in ISO (PMID:22885984) UniProt PMID:22885984 NCBI chr 1:25,622,548...25,636,106
Ensembl chr 1:26,690,359...26,703,755 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    immune system process 2524
      leukocyte activation 1007
        lymphocyte activation 819
          lymphocyte differentiation 436
            natural killer cell differentiation 34
              natural killer cell differentiation involved in immune response + 5
              negative regulation of natural killer cell differentiation + 4
              positive regulation of natural killer cell differentiation + 11
              regulation of natural killer cell differentiation + 18
Path 2
Term Annotations click to browse term
  biological_process 19315
    developmental process 6695
      cellular developmental process 4505
        cell differentiation 4504
          cell development 3203
            hemopoiesis 1032
              leukocyte differentiation 665
                mononuclear cell differentiation 537
                  lymphocyte differentiation 436
                    natural killer cell differentiation 34
                      natural killer cell differentiation involved in immune response + 5
                      negative regulation of natural killer cell differentiation + 4
                      positive regulation of natural killer cell differentiation + 11
                      regulation of natural killer cell differentiation + 18
paths to the root